Dr. Yan [HHMI Fellow] is aiming to generate profiles of phosphorylation for each kinase and phosphatase enzyme in the genome, and to relate these profiles to their in vivo functions during development. Given the large number of kinase mutations associated with various cancers, understanding the phosphorylation network could prompt treatment tailored to aberrant signaling of specific pathways.

 

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Project Title: "Building a kinase and phosphatase network using phosphorylation signatures"

Institution: Harvard Medical School

Sponsor(s) / Mentor(s): Norbert Perrimon, PhD

Cancer Type: All cancers

Research Area: Signal Transduction