Dr. Deaconescu [HHMI Fellow] is using hybrid structural methods to investigate the mechanism of transcription-coupled DNA repair and nucleotide excision repair, processes that ensure proper repair of DNA errors.  The relevance of these pathways for human health is reflected by the observations that deficiencies in these pathways result in disorders such as Cockayne syndrome, trichothiodistrophy, and xeroderma pigmentosum, a genetic disease that results in increased incidence of skin cancer.

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Project Title: "Elucidation of the mechanism of transcription-DNA repair coupling"

Institution: Brandeis University

Sponsor(s) / Mentor(s): Nikolaus Grigorieff, PhD

Cancer Type: Skin

Research Area: Structural Biology