Dr. Lyssiotis [Amgen Fellow] is studying how oncogenes affect cellular metabolism in cancer. In particular, he is interested in understanding (i) how mutations in the oncogene Kras alter cellular metabolism in pancreatic ductal adenocarcinoma to facilitate cell growth and (ii) if distinct components of KRas-mediated metabolic reprogramming can be targeted for therapeutic gain. Ultimately, this work aims to translate our understanding of pancreatic cancer cell metabolism into therapies for this devastating disease.

 

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Project Title: "Exploring the metabolic effects of oncogenic KRas in pancreatic ductal adenocarcinoma"

Institution: Beth Israel Deaconess Medical Center

Sponsor(s) / Mentor(s): Lewis C. Cantley, PhD

Cancer Type: Pancreatic

Research Area: Biochemistry