Dr. Muzzey [HHMI Fellow] is studying how both the sequence and structure of mRNAs affect the efficiency by which they are translated into protein in the yeast Candida albicans. Defects in mRNA translation have been linked to several cancers, and he hopes to reveal features of translational control that generalize to humans. Additionally, his project may highlight potential ways to combat Candida infections, which frequently afflict immune-compromised cancer patients undergoing therapy.

 

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Project Title: "Resolving general principles of cis translational regulation in eukaryotes using high-throughput and mechanistic analyses of allelic expression in Candida albicans"

Institution: University of California, San Francisco

Sponsor(s) / Mentor(s): Jonathan S. Weissman, PhD

Cancer Type: All cancers

Research Area: Genomics