Dr. Breslow [Connie and Bob Lurie Fellow] is studying the primary cilium, a cellular structure that enables cells to sense and respond to specific external cues. While disruptions to primary cilia are known to promote tumor formation and cause developmental defects, how cilia orchestrate these processes remains poorly understood. He is using a combination of genetic, biochemical and imaging approaches to investigate how lipid molecules contribute to the unique functions of cilia.

 

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Project Title: "Dissecting the functions of phosphoinositide lipids in the primary cilium"

Institution: Stanford University

Sponsor(s) / Mentor(s): Maxence V. Nachury, PhD

Cancer Type: Brain, Neuro-oncology, Kidney, Pancreatic, Skin

Research Area: Cell Biology