Dr. Simsek [Philip O’Bryan Montgomery, Jr., MD Fellow] is studying the role of ubiquitin protein signals in the maintenance of genome integrity. Since components of the ubiquitin system are often highly conserved from yeast to humans, yeast is ideally suited for the study of this complex process using a combination of functional genomics and biochemistry. The insights gained from the proposed studies may identify additional targets to combat cancer.

 

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Project Title: "Understanding the physiological relevance of distinct polyubiquitin chains in the maintenance of genome integrity"

Institution: University of California, San Francisco

Sponsor(s) / Mentor(s): David P. Toczyski, PhD

Cancer Type: All cancers

Research Area: Chromosome and Telomere Biology