Dr. Phanstiel is studying transcription factors (TF), proteins that bind to DNA and regulate gene expression. Certain TFs have well-established roles in cancer and other diseases. He is using chromatin immunopreciptation combined with high-throughput sequencing (ChIP-Seq) to map TF-DNA binding sites in a variety of yeast strains. This research is expected to be important for understanding the mechanisms controlling gene expression in humans and their variation across populations, thus providing insights into cancer and other diseases.

 

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Project Title: "Variation of transcription factor binding"

Institution: Stanford University School of Medicine

Sponsor(s) / Mentor(s): Michael P. Snyder, PhD

Cancer Type: All cancers

Research Area: Genomics