Recent genome sequencing studies have identified a large set of candidate genetic mutations implicated in a diverse range of cancer types.  However, in order to determine the causal role of each mutation in disease risk and pathology, researchers must be able to test each mutation individually in cellular or animal models.  This is severely limited by the difficulty of manipulating the genome of cells and organisms with precise control so that a specific disease can be definitively linked to single changes in the genome.

To address this challenge, Dr. Zhang proposes to engineer a comprehensive set of novel molecular tools to enable targeted modification of the mammalian genome.  He will demonstrate the power of these tools by testing genetic mutations associated with neuroblastoma and glioma brain tumors.  The development and application of these tools will establish a powerful new platform for investigating the underlying genetic and molecular mechanisms of cancer and will inform drug development.  To ensure maximal benefit and impact for the cancer community and beyond, he will also facilitate teaching and rapid open-source distribution of all tools developed.

 

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Project Title: "Development and application of genome and epigenome engineering tools for cancer research"

Institution: The Broad Institute of MIT and Harvard

Sponsor(s) / Mentor(s): n/a

Cancer Type: Brain, Neuro-oncology

Research Area: Biomedical Engineering