Dr. Gabel is investigating how dysfunction of ubiquitin ligase UBE3A, an enzyme that normally regulates amounts of specific proteins in the cell, leads to diseases such as the neurodevelopmental disorder Angelman Syndrome and common cervical cancers. These studies can provide important insights into the mechanism of disease.

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Project Title: "Dissecting the mechanism and function of Arc regulation by the Angelman Syndrome-associated ubiquitin ligase Ube3a"

Institution: Harvard Medical School

Sponsor(s) / Mentor(s): Michael E. Greenberg, PhD

Cancer Type: Gynecological

Research Area: Neuroscience