Dr. Reuter is characterizing the genomic landscape of primary human cancers using high-throughput sequencing technologies. In principle, whole genome sequencing can elucidate the entire suite of mutations responsible for cancer development in an individual. However, distinguishing cancer causing mutations from benign passenger mutations based on DNA sequence alone remains challenging. By integrating whole genome information from both the DNA and RNA, he hopes to identify novel somatic mutations in protein-coding genes, non-coding RNAs and regulatory elements in the genome. A more complete understanding of the mutations responsible for cancer development should enhance prognostic accuracy, inform treatment strategies and uncover novel therapeutic opportunities.

 

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Project Title: "Integrative analysis of human cancers using high throughput sequencing"

Institution: Stanford University

Sponsor(s) / Mentor(s): Michael P. Snyder, PhD

Cancer Type: All cancers

Research Area: RNA