Dr. Lydeard is interested in studying how proteins are targeted for destruction. Defects in maintaining the balance between newly made proteins and those to be destroyed are often linked with cancer progression. Better understanding of how these processes are regulated will help to develop more effective anticancer therapeutics.

 

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Project Title: "Defining CRL4 substrates and regulators through a systematic proteomic and functional analysis of DCAFs"

Institution: Harvard Medical School

Sponsor(s) / Mentor(s): Jeffrey Wade Harper, PhD

Cancer Type: All cancers

Research Area: Proteomics