Applying a “systems approach” to understand cancer cell metabolism

A virologist and biochemist by training, Dr. Munger is studying the metabolic activities that are altered in cancer cells.  Whereas previous studies often focused on individual metabolic activities, Dr. Munger is taking an expanded “global” approach by examining the rates of many metabolic processes simultaneously. 
 
The goal of his research is to identify novel, cancer-specific metabolic activities and define how they are genetically triggered.  Ultimately, he plans to explore new avenues to block these activities, thereby destroying cancerous cells.

Dr. Munger said, “Most funding agencies will not fund researchers whose proposals they deem ’too ambitious,’ instead preferring ‘safer’ projects.  The Damon Runyon Foundation is unique in supporting the ambitious ideas of young researchers, and in this respect, they fund research that otherwise would likely not occur.  I am extremely grateful for the Foundation’s support of my laboratory’s research.”

 

 

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Project Title: "Elucidating mechanisms of oncogenic metabolic manipulation"

Institution: University of Rochester

Sponsor(s) / Mentor(s): n/a

Cancer Type: All cancers

Research Area: Biochemistry