Dr. Sabin is studying the role of long noncoding RNAs (lncRNAs) in blood cell development. Although the precise function of most lncRNAs remains unclear, certain lncRNAs are involved in regulating gene expression and may therefore be important for proper blood cell maturation. Since several types of cancers arise from blood cell progenitors, understanding how lncRNAs function in these cells may provide novel diagnostic and therapeutic targets.

 

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Project Title: "The role of long noncoding RNAs in normal hematopoiesis and malignant transformation"

Institution: Cold Spring Harbor Laboratory

Sponsor(s) / Mentor(s): Gregory J. Hannon, PhD

Cancer Type: Leukemias, Lymphomas

Research Area: Epigenetics