Dr. Popp [HHMI Fellow] is focusing on the quality control mechanisms that cells utilize at the RNA level to ensure proper gene expression. Cells inspect and destroy aberrant mRNA messages using decay pathways; dysregulation of these RNA decay systems is implicated in various cancers. He will apply a new genetic screening method to identify components of RNA decay pathways and learn more about their role in cancer.

 

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Project Title: "A haploid genetic approach towards defining RNA decay mechanisms in mammalian cells"

Institution: University of Rochester School of Medicine and Dentistry

Sponsor(s) / Mentor(s): Lynne E. Maquat, PhD

Cancer Type: All cancers

Research Area: RNA