Dr. Dawlaty is studying DNA methylation, a type of modification that regulates gene expression during various biological processes including cancer and development. Recently, it has been shown that the Tet family of enzymes (Tet1/2/3) can convert 5mC to 5-hydroxymethylcytosine (5hmC). 5hmC is abundant in embryonic stem cells and adult tissues. His goal is to generate and utilize genetically modified mice lacking the Tet proteins in order to establish the biological relevance and in vivo requirements of Tet proteins and 5hmC in cancer and development.

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Project Title: "Role of 5hmC and Tet proteins in cancer and development"

Institution: Whitehead Institute for Biomedical Research

Sponsor(s) / Mentor(s): Rudolf Jaenisch, MD

Cancer Type: Neuro-oncology

Research Area: Epigenetics