Dr. Clark investigates the role of the immune system in controlling squamous cell carcinomas of the skin.  She has identified novel mechanisms by which these skin tumors evade the immune system: disruption of T cell homing and recruitment of regulatory T cells through misregulation of a protein called E-selectin.  Her studies focus on identifying new therapies for effective treatment of these cancers.

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Project Title: "Identification of agents that induce E-selectin expression on human endothelial cells"

Institution: Brigham and Women's Hospital

Sponsor(s) / Mentor(s): Thomas S. Kupper, MD

Cancer Type: Skin

Research Area: Tumor Immunology