Alternative splicing, the process by which a single gene can give rise to multiple, distinct protein isoforms, is broadly dysregulated in many tumors.  Recent research demonstrates that erroneous splicing can play important roles in tumor formation and growth, making it crucial that we understand the regulatory processes that give rise to aberrant splicing in cancers.  In collaboration with clinicians, Dr. Bradley seeks to identify splicing events with important roles in tumor formation and maintenance.  By combining computational and experimental techniques to understand the regulatory mechanisms underlying aberrant splicing, he aims to gain insight into fundamental tumor biology, potentially pointing the way to future therapeutics.

 

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Project Title: "Investigating the splicing co-regulatory network"

Institution: Fred Hutchinson Cancer Research Center

Sponsor(s) / Mentor(s): n/a

Cancer Type: All cancers

Research Area: RNA