Dr. Buckanovich has developed a new animal model of ovarian cancer that develops abundant tumor blood vessels, or vasculature.  He is using this model to first characterize molecular markers of tumor vasculature, and then therapeutically target them with antibodies coupled to toxic nanoparticles.  He also seeks to identify and characterize a population of cells, cancer stem cells, which play a critical role in tumor establishment and growth.  These discoveries could lead to highly effective targeted therapies.

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Project Title: "Tumor endothelial cells as a therapeutic and diagnostic target in ovarian cancer"

Institution: University of Michigan

Sponsor(s) / Mentor(s): Daniel F. Hayes, MD & Max S. Wicha, MD

Cancer Type: Gynecological

Research Area: Diagnostics