Dr. Hua aims to complete a comprehensive, genome-wide assessment of regulatory networks governing self-renewal and fate-determination programs in normal and malignant neural stem cells.  Tumor progression of certain tumor types, including glioblastoma, depends on a subpopulation of cells within the tumor called tumor stem cells.  Understanding the shared and distinct features of normal and malignant stem cells is critical to develop novel therapies that selectively target tumor stem cells but spare their normal counterparts.

 

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Project Title: "Genomic analysis of core transcriptional regulatory networks in normal and malignant neural stem cells"

Institution: MD Anderson Cancer Center

Sponsor(s) / Mentor(s): Ronald A. DePinho, MD

Cancer Type: Brain, Neuro-oncology

Research Area: Genomics