Dr. Nguyen’s [August M. Watanabe, MD, Investigator] goal is to develop novel ways of controlling donor T immune cell activity to prevent acute graft-versus-host disease (GvHD) in cancer patients treated with bone marrow transplantation. His hypothesis is that regulatory T cells (Treg) can be used to suppress GvHD while preserving beneficial anti-tumor immunity.  This work could have significant translational implications by reducing GvHD-associated mortality, thus improving the success of bone marrow transplantation in treatment of hematologic cancers such as leukemia and lymphoma.

 

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Project Title: "Organ-specific regulatory T cells as a targeted therapy for graft-versus-host disease"

Institution: The University of Chicago

Sponsor(s) / Mentor(s): Thomas F. Gajewski, MD, PhD

Cancer Type: Leukemias, Lymphomas

Research Area: Tumor Immunology