August 19, 2014 > 2014 Technology Review’s “35 Innovators under 35”

Emily P. Balskus, PhD (Damon Runyon-Rachleff Innovator ‘14-‘16) of Harvard University, Cambridge, has been named to MIT Technology Review’s list of “35 Innovators under 35” for her research focused on how gut bacteria use chemical reactions to survive.  The list is comprised of “exceptionally talented technologists whose work has great potential to transform the world.”

Click here for more.

 

August 17, 2014 > Imaging how tumor cells transition to invasion

Ian Y. Wong, PhD (Damon Runyon Fellow ‘10-‘13) of Brown University, Providence, and colleagues, developed a microchip that enabled cancer cells to be imaged as they migrated across a surface that mimics the tissue surrounding a tumor. They examined cells that had undergone epithelial-mesenchymal transition (EMT), a process in which epithelial cells that stick together within a tissue, change into mesenchymal cells that can disperse and migrate individually. EMT is thought to play a role in cancer metastasis, allowing cancer cells to escape from tumor masses and colonize distant organs. This new imaging technology allows researchers to precisely measure how these cells move. Ultimately, they hope the device can be used for preliminary testing of drugs aimed at inhibiting cancer metastasis. This study was published in the journal Nature Materials.

Click here for more.

 

Improving and Expanding Our Programs

AUGUST 2014

The Damon Runyon Cancer Research Foundation is committed to identifying and supporting exceptional early career researchers to accelerate progress against cancer. We pride ourselves on being an agile organization, able to rapidly target funding to where it can be most effective.

A recent assessment of our programs conducted by leading experts in the field of cancer research allowed us to ask if we could make a greater difference in finding cures for cancer faster. Based on the results of this rigorous review, we will be increasing our support for the nation’s best cancer researchers by 33%.

In a time of declining federal funding of research, we are stepping up to protect and encourage innovative cancer research in three major ways.


Strengthening the Damon Runyon Fellowship Award

The Damon Runyon Fellowship Award supports the training of the brightest postdoctoral scientists as they embark upon their independent research careers. Postdoctoral funding allows promising scientists time to establish their own research in the labs of senior scientists, who provide vital guidance and scientific expertise.

Typical postdoctoral fellowships offer three years of funding, but most postdoctoral work requires four or more years to complete. So that our Fellows have the support they need to pursue groundbreaking research and build their careers on the cutting edge of cancer research, we are adding a fourth year to the Damon Runyon Fellowship Award. We are the first major organization to add a fourth year to our Fellowship Award.

I am thrilled. [The award] means I can simply focus 100% on science for my postdoc training period. My mentor and I appreciate the generous support from the Foundation and hope that our project can lead to significant breakthroughs in cancer research to repay the trust of the foundation and the donors.” 
- Chao Lu, PhD, Kandarian Family Fellow

At a time when the entire funding universe is stepping back, [Damon Runyon is] moving forward.” – Leo D. Wang, MD, PhD, Damon Runyon-Sohn Fellow



Read more about the Damon Runyon Fellowship Award




Training More Physicians as Researchers

Physician-scientists are the critical link between scientific discoveries and cures because they understand cancer in patients as well as in the lab.  While our Clinical Investigator Award provides established physician-scientists with the support to pursue patient-oriented research, fewer physicians are choosing research careers in the first place.

To reverse this trend and ensure that discoveries from the lab are quickly used to help patients, we are launching a new Physician-Scientist Training Award to recruit top medical school graduates to pursue cancer research careers by offering intensive training and mentorship.

The pilot class of this program will be launched in 2015.

Read more about the Physician-Scientist Training Award


Supporting Daring Ideas

The Damon Runyon-Rachleff Innovation Award encourages our scientists to explore new ideas that, if successful, could revolutionize cancer prevention, diagnosis or treatment.  The Innovation Award is specifically designed to provide funding to extraordinary early career researchers who have an innovative new idea but lack sufficient preliminary data to obtain traditional funding. It is not designed to fund incremental advances.

To make certain we are supporting projects with strong potential for high impact in the cancer field, the selection committee will assess each project after two years to see if the idea continues to show great promise.  If so, we will extend funding for an additional two years.  This will enable us to focus our investments on the projects with the highest potential for radically transforming cancer care. 

Read more about the Damon Runyon-Rachleff Innovation Award


All together, we will be increasing our investment in innovative cancer research by 33% over the next 12 months.

These changes demonstrate our belief that continual assessment and expansion of our programs will ensure that the most brilliant scientists remain committed to groundbreaking cancer research. 


August 1, 2014 > 2014 William B. Coley Award for Distinguished Research in Tumor Immunology

Gordon J. Freeman, PhD (Damon Runyon Fellow ‘79-‘81), of Harvard Medical School and Dana-Farber Cancer Institute, Boston, was named one of four recipients of the 2014 William B. Coley Award for Distinguished Research in Tumor Immunology.  He is recognized for his contributions to the discovery of the programmed cell death-1 (PD-1) receptor pathway, a new immune system checkpoint that has been shown in clinical studies to be a highly promising target in cancer immunotherapy.  PD-1 inhibitor drugs are effective in treating several types of deadly cancer, including melanoma, non-small cell lung cancer, head and neck cancer, bladder cancer, and kidney cancer.

Click here for more.

 

July 30, 2014 > Single cell sequencing of breast cancer genome

Nicholas E. Navin, PhD (Nadia’s Gift Foundation Damon Runyon-Rachleff Innovator ’13-’15) and colleagues at MD Anderson Cancer Center, Houston, developed a single cell sequencing tool (NUC-SEQ) that can measure genome-wide mutations in individual cancer cells. This study revealed that different subtypes of breast cancer have varied tumor diversity, and that different tumor cells grow at dramatically different speeds. These findings may have important implications for the diagnosis and treatment of breast cancer. This work was published in the journal Nature.

Click here for more.

 

New Discoveries eNewsletter:  May - July 2014

Damon Runyon Cancer Research Foundation | New Discoveries Newsletter

Damon Runyon Logo
May-July 2014

Damon Runyon Newsletter

Dear Damon Runyon Scientists,

Congratulations to the newest awardees of the Clinical Investigator, Fellowship, and the Damon Runyon-Sohn Pediatric Cancer Fellowship Awards: 29 awards were granted, totaling over $7 million.

We have more exciting news to share with you. As you know, the mission of the Damon Runyon Cancer Research Foundation is to provide today’s best young scientists with funding to pursue innovative research. After a rigorous strategic program review, upon the recommendation of our Scientific Committee, our Board of Directors recently approved increasing our award programs budget over 30%,  from $12M to $16M annually. We are pleased to announce that we are expanding existing programs as well as introducing a new pilot program for physician-scientists, all aimed to fill gaps in funding and support the best early career cancer researchers.

One very important change is that we are increasing the Damon Runyon Fellowship to a four-year award (from three years). Almost all other postdoctoral fellowships are currently three years or less. Our new award structure recognizes the reality that virtually all postdoctoral fellowship training now takes 4 to 5 years to complete, on average. In a time of declining NIH funding rates, we believe that it is increasingly important for us to provide additional sustained funding to Damon Runyon Fellows. To give you an idea of how meaningful this is to our fellows, here is one response we received from a current fellow: 

“Thank you for this amazing gift. In this increasingly uncertain funding climate, I applaud Damon Runyon in its unwavering efforts to support young scientists. Less time writing for funding directly translates into more time thinking about and performing innovative science.”

To address the continuing shortage of MDs going into research, we will be piloting a new Damon Runyon Physician-Scientist Training Award, aimed to capture “late bloomers”—young physicians who discovered a passion for cancer research during medical school or their residency, but who have not received training in scientific research methods and thus will not be competitive in seeking grant funding. The new award will provide generous funding for four years and, importantly, the ability to work with a world-class mentor who has a proven track record of training MDs to become top scientists. We will also provide funds for medical school loan repayment. We will be launching this award in the fall and will notify you of the RFA and application deadline.

We are hopeful that our programmatic changes will encourage other funders of biomedical research to follow suit with increased support and sustained commitment to early career scientists.

Our Scientific Committees are meeting this fall to select new classes of Damon Runyon Fellows, Dale F. Frey Scientists and Damon Runyon-Rachleff Innovators. We are also looking forward to our Annual Fellows’ Retreat, which will take place in Beverly, Massachusetts this year.

Please see below for the latest updates from your fellow Damon Runyon scientists – current and former. These are just the publications and awards that we are aware of, so we apologize if we have not included your work. Thanks again to those of you who have sent us updates on your recent progress. Please continue to stay in touch. Enjoy the summer!

Best regards,
Yung

Yung S. Lie, PhD
Deputy Director and Chief Scientific Officer
Damon Runyon Cancer Research Foundation
yung.lie@damonrunyon.org

 

UPCOMING DEADLINES and EVENTS

Fellowship Award
Next application deadline: August 15

Runyon 5K
Sunday, August 3
Yankee Stadium, One East 161st Street, Bronx, New York
9:30am - 2:00pm (staggered start)

Join us for the sixth annual Runyon 5K, a unique cancer research fundraising run/walk that uses Yankee Stadium as its course.  Run or walk the concourses and ramps, climb stairs between levels, and take your own victory laps around the warning track that circles the field.  We welcome participation from you, our scientists, and please tell your family and friends!  You can also support Team Damon Runyon here.

  



AWARDS and HONORS

   

2014 Pew-Stewart Scholars for Cancer Research:
Arvin Dar, PhD (Innovator ‘14-‘16),
Icahn School of Medicine at Mount Sinai, New York
Agnel Sfier, PhD (Innovator ‘13-‘15), New York University School of Medicine, New York

American Society for Microbiology Career Development Grant for Postdoctoral Women:
Yanling Wang, PhD (Robert Black Fellow ‘12-‘14),
University of California, Los Angeles

2014 Harold M. Weintraub Graduate Student Award:
Liron Bar-Peled, PhD (Lallage Feazel Wall Fellow ‘14-‘17),
Scripps Research Institute, La Jolla

PUBLICATIONS

The Cancer Genome Atlas Research Network
(led by Matthew M. Meyerson, MD, PhD, (Fellow ‘95-‘98), Dana Farber Cancer Institute, Boston)
Comprehensive molecular profiling of lung adenocarcinoma.
Nature 2014 Jul 9; doi:10.1038/nature13385.

Omar Abdel-Wahab, MD (Edward P. Evans Foundation Clinical Investigator ‘13-‘16), Memorial Sloan Kettering Cancer Center, New York
Hematopoietic stem cell origin of BRAFV600E mutations in hairy cell leukemia. Chung SS, Kim E, Park JH, Chung YR, Lito P, Teruya-Feldstein J, Hu W, Beguelin W, Monette S, Duy C, Rampal R, Telis L, Patel M, Kim MK, Huberman K, Bouvier N, Berger MF, Melnick AM, Rosen N, Tallman MS, Park CY, Abdel-Wahab O. Sci Transl Med. 2014 May 28;6(238):238ra71.

Frequent ASXL2 mutations in acute myeloid leukemia patients with t(8;21)/RUNX1-RUNX1T1 chromosomal translocations. Micol JB, Duployez N, Boissel N, Petit A, Geffroy S, Nibourel O, Lacombe C, Lapillonne H, Etancelin P, Figeac M, Renneville A, Castaigne S, Leverger G, Ifrah N, Dombret H, Preudhomme C, Abdel-Wahab O, Jourdan E. Blood. 2014 Jun 27. pii: blood-2014-04-571018.

Himisha Beltran, MD (Gordon Family Clinical Investigator ‘13-‘16), Weill Medical College of Cornell University, New York
Aggressive variants of castration-resistant prostate cancer. Beltran H, Tomlins S, Aparicio A, Arora V, Rickman D, Ayala G, Huang J, True L, Gleave ME, Soule H, Logothetis C, Rubin MA. Clin Cancer Res. 2014 Jun 1;20(11):2846-50.

Sean Bendall, PhD (Dale Frey Scientist ‘14-‘16, Fellow ‘09-‘12), Stanford University, Stanford
Single-cell trajectory detection uncovers progression and regulatory coordination in human B cell development. Bendall SC, Davis KL, Amir el-AD, Tadmor MD, Simonds EF, Chen TJ, Shenfeld DK, Nolan GP, Pe’er D. Cell. 2014 Apr 24;157(3):714-25. doi: 10.1016/j.cell.2014.04.005.

Michael Bittner, PhD (Fellow ‘77-‘78), Translational Genomics Research Institute, Phoenix
Mcl-1 mediates TWEAK/Fn14-induced non-small cell lung cancer survival and therapeutic response. Whitsett TG, Mathews IT, Cardone MH, Lena RJ, Pierceall WE, Bittner M, Sima C, LoBello J, Weiss GJ, Tran NL. Mol Cancer Res. 2014 Apr;12(4):550-9. doi: 10.1158/1541-7786.MCR-13-0458.

Angela Brooks, PhD (Merck Fellow ‘12-‘16), Dana Farber Cancer Center, Boston
A pan-cancer analysis of transcriptome changes associated with somatic mutations in U2AF1 reveals commonly altered splicing events. Brooks AN, Choi PS, de Waal L, Sharifnia T, Imielinski M, Saksena G, Pedamallu CS, Sivachenko A, Rosenberg M, Chmielecki J, Lawrence MS, DeLuca DS, Getz G, Meyerson M. PLoS One. 2014 Jan 31;9(1):e87361.

Joseph Califano, MD (Clinical Investigator ‘01-‘06), The Johns Hopkins University, Baltimore
Novel insight into mutational landscape of head and neck squamous cell carcinoma. Gaykalova DA, Mambo E, Choudhary A, Houghton J, Buddavarapu K, Sanford T, Darden W, Adai A, Hadd A, Latham G, Danilova LV, Bishop J, Li RJ, Westra WH, Hennessey P, Koch WM, Ochs MF, Califano JA, Sun W. PLoS One. 2014 Mar 25;9(3):e93102. doi: 10.1371/journal.pone.0093102.

Andrew T. Chan, MD, MPH (Clinical Investigator ‘08-‘13), Massachusetts General Hospital, Boston
Aspirin and the Risk of Colorectal Cancer in Relation to the Expression of 15-Hydroxyprostaglandin Dehydrogenase (HPGD). Fink SP1, Yamauchi M, Nishihara R, Jung S, Kuchiba A, Wu K, Cho E, Giovannucci E, Fuchs CS, Ogino S, Markowitz SD, Chan AT. Sci Transl Med. 2014 Apr 23;6(233):233re2. doi: 10.1126/scitranslmed.3008481.

A Prospective Study of Macrophage Inhibitory Cytokine-1 (MIC-1/GDF15) and Risk of Colorectal Cancer. Mehta RS1, Song M, Bezawada N, Wu K, Garcia-Albeniz X, Morikawa T, Fuchs CS, Ogino S, Giovannucci EL, Chan AT. J Natl Cancer Inst. 2014 Apr 1;106(4):dju016. doi: 10.1093/jnci/dju016. Epub 2014 Feb 24.

Andrew T. Chan, MD, MPH and Wendy Garrett MD, PhD (Fellow ‘06-‘09), Harvard School of Public Health, Boston
Relating the metatranscriptome and metagenome of the human gut. Franzosa EA, Morgan XC, Segata N, Waldron L, Reyes J, Earl AM, Giannoukos G, Boylan MR, Ciulla D, Gevers D, Izard J, Garrett WS, Chan AT, Huttenhower C. Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):E2329-38.

Clark C. Chen, MD, PhD (Fellow ‘04-‘06), University of California, San Diego
Genome-wide shRNA screen revealed integrated mitogenic signaling between dopamine receptor D2 (DRD2) and epidermal growth factor receptor (EGFR) in glioblastoma. Jie Li, Shan Zhu, David Kozono, Kimberly Ng, Diahnn Futalan, Ying Shen, Johnny C. Akers, Tyler Steed, Deepa Kushwaha, Michael Schlabach, Bob S. Carter, Chang-Hyuk Kwon, Frank Furnari, Webster Cavenee, Stephen Elledge, Clark C. Chen.  Oncotarget, March 2014

Chonghui Cheng, PhD (Fellow ‘01-‘03), Northwestern University School of Medicine, Chicago
Cell type-restricted activity of hnRNPM promotes breast cancer metastasis via regulating alternative splicing. Xu Y, Gao XD, Lee JH, Huang H, Tan H, Ahn J, Reinke LM, Peter ME, Feng Y, Gius D, Siziopikou KP, Peng J, Xiao X, Cheng C. Genes Dev. 2014 Jun 1;28(11):1191-203.

Ralph Deberardinis. MD, PhD (Clinical Investigator ‘11-‘14), University of Texas SW Medical Center, Dallas
Oxidation of alpha-ketoglutarate is required for reductive carboxylation in cancer cells with mitochondrial defects. Mullen AR, Hu Z, Shi X, Jiang L, Boroughs LK, Kovacs Z, Boriack R, Rakheja D, Sullivan LB, Linehan WM, Chandel NS, DeBerardinis RJ. Cell Rep. 2014 Jun 12;7(5):1679-90.

Madhav Dhodapkar, MD (Clinical Investigator ‘02-‘07), Yale University School of Medicine, New Haven
Induction of antigen-specific immunity with a vaccine targeting NY-ESO-1 to the dendritic cell receptor DEC-205. Dhodapkar MV1, Sznol M, Zhao B, Wang D, Carvajal RD, Keohan ML, Chuang E, Sanborn RE, Lutzky J, Powderly J, Kluger H, Tejwani S, Green J, Ramakrishna V, Crocker A, Vitale L, Yellin M, Davis T, Keler T. Sci Transl Med. 2014 Apr 16;6(232):232ra51.

Charles Drake, MD, PhD (Clinical Investigator ‘04-‘09), The Johns Hopkins University, Baltimore
Chronic Inflammation in Benign Prostate Tissue Is Associated with High-Grade Prostate Cancer in the Placebo Arm of the Prostate Cancer Prevention Trial. B. Gurel, M. S. Lucia, I. M. Thompson, P. J. Goodman, C. M. Tangen, A. R. Kristal, H. L. Parnes, A. Hoque, S. M. Lippman, S. Sutcliffe, S. B. Peskoe, C. G. Drake, W. G. Nelson, A. M. De Marzo, E. A. Platz.  Cancer Epidemiology Biomarkers & Prevention, 2014; DOI: 10.1158/1055-9965.EPI-13-1126

Sandra E. Encalada, PhD (Fellow ‘07-‘11), The Scripps Research Institute, La Jolla
Biophysical challenges to axonal transport: motor-cargo deficiencies and neurodegeneration. Encalada SE, Goldstein LSB. Annu Rev Biophys. 2014, 43:7.1-7.29doi:10.1146/annurev-biophys-051013-022746.

Fast axonal transport of the proteasome complex depends on membrane interaction and molecular motor function. Otero MG, Alloatti M, Cromberg LE, Almenar-Queralt A, Encalada SE, Pozo Devoto VM, Goldstein LSB, Falzone TL.  J. Cell Sci. 2014, 127: 1537-1549.

Patricia Ernst, PhD (Fellow ‘97-‘00), Dartmouth Medical School, Hanover
The histone methyltransferase activity of MLL1 is dispensable for hematopoiesis and leukemogenesis. Mishra BP, Zaffuto KM, Artinger EL, Org T, Mikkola HK, Cheng C, Djabali M, Ernst P. Cell Rep. 2014 May 22;7(4):1239-47.

Andrew L. Feldman, MD (Clinical Investigator ‘09-‘14), Mayo Clinic, Rochester
ALK-negative anaplastic large cell lymphoma is a genetically heterogeneous disease with widely disparate clinical outcomes. Parilla Castellar ER, Jaffe ES, Said JW, Swerdlow SH, Ketterling RP, Knudson RA, Sidhu JS, Hsi ED, Karikehalli S, Jiang L, Vasmatzis G, Gibson SE, Ondrejka S, Nicolae A, Grogg KL, Allmer C, Ristow KM, Wilson WH, Macon WR, Law ME, Cerhan JR, Habermann TM, Ansell SM, Dogan A, Maurer MJ, Feldman AL. Blood. 2014 Jun 3.

Elaine Fuchs, PhD (Damon Runyon Board Member, Fellow ‘77), The Rockefeller University, New York
Transit-amplifying cells orchestrate stem cell activity and tissue regeneration. Hsu YC, Li L, Fuchs E. Cell. 2014 May 8;157(4):935-49.

Forces generated by cell intercalation tow epidermal sheets in mammalian tissue morphogenesis. Heller E, Kumar KV, Grill SW, Fuchs E. Dev Cell. 2014 Mar 31;28(6):617-32.

SOX9: a stem cell transcriptional regulator of secreted niche signaling factors. Kadaja M1, Keyes BE, Lin M, Pasolli HA, Genander M, Polak L, Stokes N, Zheng D, Fuchs E. Genes Dev. 2014 Feb 15;28(4):328-41. doi: 10.1101/gad.233247.113.

Nathanael Gray, PhD (Innovator ‘08-‘10 ), Dana Farber Cancer Institute, Boston
Discovery of a potent, covalent BTK inhibitor for B-cell lymphoma. Wu H, Wang W, Liu F, Weisberg EL, Tian B, Chen Y, Li B, Wang A, Wang B, Zhao Z, McMillin DW, Hu C, Li H, Wang J, Liang Y, Buhrlage SJ, Liang J, Liu J, Yang G, Brown JR, Treon SP, Mitsiades CS, Griffin JD, Liu Q, Gray NS. ACS Chem Biol. 2014 May 16;9(5):1086-91.

Nicholas Guydosh, PhD (Fellow ‘10-‘13) and Rachel Green, PhD (Innovation Award Committee Member, Fellow ‘93-‘96), The Johns Hopkins University School of Medicine, Baltimore
Dom34 rescues ribosomes in 3’ untranslated regions. Guydosh NR, Green R. Cell. 2014 Feb 27;156(5):950-62. doi: 10.1016/j.cell.2014.02.006.

Christopher Hale, PhD (Fellow ‘10-‘13), University of California, Los Angeles
Transcriptional gene silencing by Arabidopsis microrchidia homologues involves the formation of heteromers. Moissiard G1, Bischof S1, Husmann D1, Pastor WA1, Hale CJ1, Yen L1, Stroud H1, Papikian A1, Vashisht AA2, Wohlschlegel JA2, Jacobsen SE3. Proc Natl Acad Sci U S A. 2014 May 20;111(20):7474-9. doi: 10.1073/pnas.1406611111. Epub 2014 May 5.

John Heymach, MD, PhD (Clinical Investigator ‘04-‘09), MD Anderson Cancer Center, Houston
A High Content Clonogenic Survival Drug Screen Identifies MEK Inhibitors as Potent Radiation Sensitizers for KRAS Mutant Non-Small-Cell Lung Cancer. Lin SH, Zhang J, Giri U, Stephan C, Sobieski M, Zhong L, Mason KA, Molkentine J, Thames HD, Yoo SS, Heymach JV. J Thorac Oncol. 2014 Jul;9(7):965-73.

Tumor endothelial markers define novel subsets of cancer-specific circulating endothelial cells associated with antitumor efficacy. Mehran R, Nilsson M, Khajavi M, Du Z, Cascone T, Wu HK, Cortes A, Xu L, Zurita A, Schier R, Riedel B, El-Zein R, Heymach JV. Cancer Res. 2014 May 15;74(10):2731-41.

Sujun Hua, PhD (Fellow ‘10-‘13), MD Anderson Cancer Center, Houston
Yap1 activation enables bypass of oncogenic kras addiction in pancreatic cancer. Kapoor A, Yao W, Ying H, Hua S, Liewen A, Wang Q, Zhong Y, Wu CJ, Sadanandam A, Hu B, Chang Q, Chu GC, Al-Khalil R, Jiang S, Xia H, Fletcher-Sananikone E, Lim C, Horwitz GI, Viale A, Pettazzoni P, Sanchez N, Wang H, Protopopov A, Zhang J, Heffernan T, Johnson RL, Chin L, Wang YA, Draetta G, DePinho RA. Cell. 2014 Jul 3;158(1):185-97.

Susan Kaech, PhD (Fellow ‘99-‘02), Yale University School of Medicine, New Haven
Immune-Based Antitumor Effects of BRAF Inhibitors Rely on Signaling by CD40L and IFNγ. Ho PC, Meeth KM, Tsui YC, Srivastava B, Bosenberg MW, Kaech SM. Cancer Res. 2014 Jun 15;74(12):3205-17.

Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1. Parish IA, Marshall HD, Staron MM, Lang PA, Brüstle A, Chen JH, Cui W, Tsui YC, Perry C, Laidlaw BJ, Ohashi PS, Weaver CT, Kaech SM. J Clin Invest. 2014 Jul 8. pii: 66108.

Vassiliki Karantza, MD, PhD (Clinical Investigator ‘08-‘13), Robert Wood Johnson Medical School, New Brunswick
ERBB2 overexpression suppresses stress-induced autophagy and renders ERBB2-induced mammary tumorigenesis independent of monoallelic Becn1 loss. Lozy F, Cai-McRae X, Teplova I, Price S, Reddy A, Bhanot G, Ganesan S, Vazquez A, Karantza V. Autophagy. 2014 Apr;10(4):662-76.

Autophagy inhibition by chloroquine sensitizes HT-29 colorectal cancer cells to concurrent chemoradiation. Schonewolf CA, Mehta M, Schiff D, Wu H, Haffty BG, Karantza V, Jabbour SK. World J Gastrointest Oncol. 2014 Mar 15;6(3):74-82.

Hannah L. Klein, PhD (Fellow ‘76-‘78), New York University Medical Center, New York
Avoidance of ribonucleotide-induced mutations by RNase H2 and Srs2-Exo1 mechanisms. Potenski CJ, Niu H, Sung P, Klein HL. Nature. 2014 Jul 10;511(7508):251-4.

Gabriel Lander, PhD (Dale Frey Scientist ‘13-‘15, Fellow ‘10-‘13), The Scripps Research Institute, La Jolla
High-resolution microtubule structures reveal the structural transitions in αβ-tubulin upon GTP hydrolysis. Alushin GM, Lander GC, Kellogg EH, Zhang R, Baker D, Nogales E. Cell. 2014 May 22;157(5):1117-29

Liana Lareau, PhD (Fellow ‘09-‘12), University of California, Berkeley
Distinct stages of the translation elongation cycle revealed by sequencing ribosome-protected mRNA fragments. Lareau LF, Hite DH, Hogan GJ, Brown PO. Elife. 2014 May 9;3:e01257.

Grant McArthur, PhD, FRACP (Fellow ‘95-‘98), Peter MacCallum Cancer Institute, East Melbourne
Safety and efficacy of vemurafenib in BRAF(V600E) and BRAF(V600K) mutation-positive melanoma (BRIM-3): extended follow-up of a phase 3, randomised, open-label study. McArthur GA, Chapman PB, Robert C, Larkin J, Haanen JB, Dummer R, Ribas A, Hogg D, Hamid O, Ascierto PA, Garbe C, Testori A, Maio M, Lorigan P, Lebbé C, Jouary T, Schadendorf D, O’Day SJ, Kirkwood JM, Eggermont AM, Dréno B, Sosman JA, Flaherty KT, Yin M, Caro I, Cheng S, Trunzer K, Hauschild A. Lancet Oncol. 2014 Mar;15(3):323-32.

Response of BRAF-mutant melanoma to BRAF inhibition is mediated by a network of transcriptional regulators of glycolysis. Parmenter TJ, Kleinschmidt M, Kinross KM, Bond ST, Li J, Kaadige MR, Rao A, Sheppard KE, Hugo W, Pupo GM, Pearson RB, McGee SL, Long GV, Scolyer RA, Rizos H, Lo RS, Cullinane C, Ayer DE, Ribas A, Johnstone RW, Hicks RJ, McArthur GA. Cancer Discov. 2014 Apr;4(4):423-33.

Ann Mullally, MD (Clinical Investigator ‘13-‘16), Brigham and Women’s Hospital, Boston
Csnk1a1 inhibition has p53-dependent therapeutic efficacy in acute myeloid leukemia. Järås M1, Miller PG, Chu LP, Puram RV, Fink EC, Schneider RK, Al-Shahrour F, Peña P, Breyfogle LJ, Hartwell KA, McConkey ME, Cowley GS, Root DE, Kharas MG, Mullally A, Ebert BL. J Exp Med. 2014 Apr 7;211(4):605-12. doi: 10.1084/jem.20131033.

Loss of Function of TET2 Cooperates with Constitutively Active KIT in Murine and Human Models of Mastocytosis. De Vita S, Schneider RK, Garcia M, Wood J, Gavillet M, Ebert BL, Gerbaulet A, Roers A, Levine RL, Mullally A, Williams DA. PLoS One. 2014 May 2;9(5):e96209.

Trudy G. Oliver, PhD (Innovator ‘13-‘15) Huntsman Cancer Institute, Salt Lake City
Sox2 cooperates with lkb1 loss in a mouse model of squamous cell lung cancer. Mukhopadhyay A, Berrett KC, Kc U, Clair PM, Pop SM, Carr SR, Witt BL, Oliver TG. Cell Rep. 2014 Jul 10;8(1):40-9.

Sarah B. Pierce, PhD (Fellow ‘98-‘01) University of Washington, Seattle
Mutant adenosine deaminase 2 in a polyarteritis nodosa vasculopathy. Navon Elkan P, Pierce SB, Segel R, Walsh T, Barash J, Padeh S, Zlotogorski A, Berkun Y, Press JJ, Mukamel M, Voth I, Hashkes PJ, Harel L, Hoffer V, Ling E, Yalcinkaya F, Kasapcopur O, Lee MK, Klevit RE, Renbaum P, Weinberg-Shukron A, Sener EF, Schormair B, Zeligson S, Marek-Yagel D, Strom TM, Shohat M, Singer A, Rubinow A, Pras E, Winkelmann J, Tekin M, Anikster Y, King MC, Levy-Lahad E. N Engl J Med. 2014 Mar 6;370(10):921-31.

Matthew Pratt, PhD (Innovator ‘12-‘14), University of Southern California, Los Angeles
Identification of O-GlcNAc Modification Targets in Mouse Retinal Pericytes: Implication of p53 in Pathogenesis of Diabetic Retinopathy. Gurel Z, Zaro BW, Pratt MR, Sheibani N. PLoS One. 2014 May 1;9(5):e95561.

Tiffany Reese, PhD (Fellow ‘09-‘12), Washington University, St. Louis
Helminth infection reactivates latent γ-herpesvirus via cytokine competition at a viral promoter. Reese TA, Wakeman BS, Choi HS, Hufford MM, Huang SC, Zhang X, Buck MD, Jezewski A, Kambal A, Liu CY, Goel G, Murray PJ, Xavier RJ, Kaplan MH, Renne R, Speck SH, Artyomov MN, Pearce EJ, Virgin HW. Science. 2014 Jun 26. pii: 1254517

Barry S. Rosenstein, MD, PhD (Fellow ‘78), Icahn School of Medicine at Mount Sinai, New York
A three-stage genome-wide association study identifies a susceptibility locus for late radiotherapy toxicity at 2q24.1. Fachal L, Gómez-Caamaño A, Barnett GC, Peleteiro P, Carballo AM, Calvo-Crespo P, Kerns SL, Sánchez-García M, Lobato-Busto R, Dorling L, Elliott RM, Dearnaley DP, Sydes MR, Hall E, Burnet NG, Carracedo A, Rosenstein BS, West CM, Dunning AM, Vega A. Nat Genet. 2014 Jun 29. doi: 10.1038/ng.3020

Julien Sage, PhD (Fellowship Award Committee Member, Scholar ‘05-‘07), Stanford University, Stanford
SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer. Mazur PK, Reynoird N, Khatri P, Jansen PW, Wilkinson AW, Liu S, Barbash O, Van Aller GS, Huddleston M, Dhanak D, Tummino PJ, Kruger RG, Garcia BA, Butte AJ, Vermeulen M, Sage J, Gozani O. Nature. 2014 Jun 12;510(7504):283-7.

Alice Shaw, MD, PhD, (Fellow ‘04-‘05), Massachusetts General Hospital, Boston
The ALK inhibitor ceritinib overcomes crizotinib resistance in non-small cell lung cancer. Friboulet L, Li N, Katayama R, Lee CC, Gainor JF, Crystal AS, Michellys PY, Awad MM, Yanagitani N, Kim S, Pferdekamper AC, Li J, Kasibhatla S, Sun F, Sun X, Hua S, McNamara P, Mahmood S, Lockerman EL, Fujita N, Nishio M, Harris JL, Shaw AT, Engelman JA. Cancer Discov. 2014 Jun;4(6):662-73.

Ceritinib in ALK-rearranged non-small-cell lung cancer. Shaw AT, Kim DW, Mehra R, Tan DS, Felip E, Chow LQ, Camidge DR, Vansteenkiste J, Sharma S, De Pas T, Riely GJ, Solomon BJ, Wolf J, Thomas M, Schuler M, Liu G, Santoro A, Lau YY, Goldwasser M, Boral AL, Engelman JA. N Engl J Med. 2014 Mar 27;370(13):1189-97.

William Shih, PhD (Fellow ‘01-‘04), Dana Farber Cancer Institute, Boston
Virus-inspired membrane encapsulation of DNA nanostructures to achieve in vivo stability. Perrault SD, Shih WM. ACS Nano. 2014 May 27;8(5):5132-40.

Peter J. Skene, PhD (Fellow ‘12-‘15), Fred Hutchinson Cancer Research Center, Seattle
The nucleosomal barrier to promoter escape by RNA polymerase II is overcome by the chromatin remodeler Chd1. Skene PJ, Hernandez AE, Groudine M, Henikoff S. Elife. 2014 Apr 15;3:e02042.

Georgios Skiniotis, PhD (Fellow ‘04-‘07), University of Michigan, Ann Arbor
Structural rearrangements of a polyketide synthase module during its catalytic cycle. Whicher JR, Dutta S, Hansen DA, Hale WA, Chemler JA, Dosey AM, Narayan AR, Håkansson K, Sherman DH, Smith JL, Skiniotis G. Nature. 2014 Jun 26;510(7506):560-4.

Eranthie Weerapana, PhD (Innovator ‘12-‘14), Boston College, Chestnut Hill
Optimized metal-organic-framework nanospheres for drug delivery: evaluation of small-molecule encapsulation. Zhuang J, Kuo CH, Chou LY, Liu DY, Weerapana E, Tsung CK. ACS Nano. 2014 Mar 25;8(3):2812-9.

Eileen White, PhD (Fellow ‘83-‘85), Rutgers University, New Brunswick
Autophagy is required for glucose homeostasis and lung tumor maintenance. Karsli-Uzunbas G, Guo JY, Price S, Teng X, Laddha SV, Khor S, Kalaany NY, Jacks T, Chan CS, Rabinowitz JD, White E. Cancer Discov. 2014 May 29. pii: CD-14-0363.

Arun Wiita, MD, PhD (Fellow ‘12-‘16), University of California, San Francisco
Circulating proteolytic signatures of chemotherapy-induced cell death in humans discovered by N-terminal labeling. Wiita AP, Hsu GW, Lu CM, Esensten JH, Wells JA. Proc Natl Acad Sci U S A. 2014 May 27;111(21):7594-9.

Monte Winslow, PhD (Fellow ‘06-‘09), Stanford University School of Medicine, Stanford
A conditional system to specifically link disruption of protein-coding function with reporter expression in mice. Chiou SH, Kim-Kiselak C, Risca VI, Heimann MK, Chuang CH, Burds AA, Greenleaf WJ, Jacks TE, Feldser DM, Winslow MM. Cell Rep. 2014 Jun 26;7(6):2078-86.

Obligate progression precedes lung adenocarcinoma dissemination. Caswell DR, Chuang CH, Yang D, Chiou SH, Cheemalavagu S, Kim-Kiselak C, Connolly A, Winslow MM. Cancer Discov. 2014 Jul;4(7):781-9.

Rui Yue, PhD (Fellow ‘12-‘15), University of Texas SW Medical Center, Dallas
Leptin-Receptor-Expressing Mesenchymal Stromal Cells Represent the Main Source of Bone Formed by Adult Bone Marrow. Zhou BO, Yue R, Murphy MM, Peyer JG, Morrison SJ. Cell Stem Cell. 2014 Jun 18. pii: S1934-5909(14)00256-2.

Alexandra Zidovska, PhD (Fellow ‘10-‘12), Harvard Medical School, Boston
Chromatin hydrodynamics. Bruinsma R, Grosberg AY, Rabin Y, Zidovska A. Biophys J. 2014 May 6;106(9):1871-81.

© 2011 Damon Runyon. All Rights Reserved  |  Privacy policy

 

Damon Runyon Foundation Grants Prestigious Fellowship Awards to 16 Top Young Scientists

Grants totaling over $3.3M give early career investigators independence to pursue novel ideas


New York, NY (July 14, 2014)  – The Damon Runyon Cancer Research Foundation, a non-profit organization focused on supporting innovative early career researchers, named 16 new Damon Runyon Fellows at its spring Fellowship Award Committee review. The recipients of this prestigious, four-year award are outstanding postdoctoral scientists conducting basic and translational cancer research in the laboratories of leading senior investigators across the country. The Fellowship encourages the nation’s most promising young scientists to pursue careers in cancer research by providing them with independent funding ($208,000 each for basic scientists, $248,000 for physician-scientists) to work on innovative projects.

May 2014 Damon Runyon Fellows:

Caitlin A. Brennan, PhD [Dennis and Marsha Dammerman Fellow], with her sponsor Wendy S. Garrett, MD, PhD, at the Harvard School of Public Health, Boston, studies colorectal cancer and its connection to the human microbiota- the collection of bacteria and other microbes associated with the body in both healthy and disease states. Her research will investigate how specific bacteria signal to both the immune system and other microbes in the development of colorectal cancer.

Dennis L. Buckley, PhD [Merck Fellow],
with his sponsor James E. Bradner, MD, at the Dana-Farber Cancer Institute, Boston, aims to develop improved inhibitors of BET-bromodomain proteins for treatment of multiple cancers, such as NUT-midline carcinoma, acute leukemia, hematological malignancies and solid tumors. In addition, he will evaluate both novel and existing BET inhibitors in neuroblastoma. His goal is to chemically generate drugs with improved efficacy or lower side effects.

Casey A. Gifford, PhD [HHMI Fellow],
with her sponsor Deepak Srivastava, MD, at the Gladstone Institutes, San Francisco, aims to define the roles for DNA-binding proteins that can manipulate DNA conformation in the nucleus. DNA is maintained in an ordered conformation that contributes to control of gene expression and cellular identity. She will employ next-generation sequencing approaches and human stem cells to better understand why the loss or aberrant expression of these DNA-binding proteins leads to cancer.

Keren I. Hilgendorf, PhD [Layton Family Fellow],
with her sponsor Peter K. Jackson, PhD, at the Stanford University School of Medicine, Stanford, is exploring the role of primary cilia in regulating cell proliferation and differentiation. The primary cilium is an antenna-like cellular protrusion that is localized on the surface of most vertebrate cells and functions in chemo- and mechanosensation. In many cancers, primary cilia are lost, so cilia-mediated signaling pathways are deregulated.

Fuguo Jiang, PhD [Merck Fellow],
with his sponsor Jennifer A. Doudna, PhD, at the University of California, Berkeley, is studying the CRISPR-Cas system, which has been adopted as a robust and versatile platform for genome engineering in human cells as well as other experimental systems. He aims to use a combination of biochemical and biophysical approaches to investigate the detailed molecular mechanism of RNA-guided DNA targeting and recognition by CRISPR-Cas9. The results of this research will provide a fundamental understanding of the Cas9 enzyme family and will support its use for gene therapies against cancers.

Avinash Khanna, PhD [Rebecca Ridley Kry Fellow],
with his sponsor Matthew D. Shair, PhD, at Harvard University, Cambridge, studies a type of leukemia called mixed lineage leukemia (MLL), which often results in early relapse and a poor prognosis for the patient. Recently, it was found that inhibition of a protein called Mediator diminishes the ability of AML cancer cells to grow and proliferate. This research will use small molecules to elucidate the chemical biology of Mediator proteins.

Yin Liu, PhD [Layton Family Fellow],
with her sponsor Mark A. Krasnow, MD, PhD, at Stanford University, Stanford, studies lung biology. The lung is innervated by diverse types of sensory neurons, collectively called pulmonary sensory neurons. These neurons detect a variety of physiological stimuli from the lung and inform the central nervous system about the state of the lung. Lung cancer, one of the most common cancers with a high rate of lethality, is associated with symptoms such as chronic cough, shortness of breath, and referred cranial facial pain. Her research will examine how pulmonary sensory neurons recognize and respond to lung tumors and mediate lung cancer-associated clinical symptoms.

Chao Lu, PhD [Kandarian Family Fellow],
with his sponsor C. David Allis, PhD, at The Rockefeller University, New York, is studying histones, proteins that fold DNA into high-order structures, which is critical for proper gene expression. Mutations in histones are mutated in certain types of pediatric brain tumors and sarcomas, including a rare bone cancer called chondroblastoma. He aims to understand the biochemical and molecular mechanisms by which histone proteins function and how they are perturbed in tumor cells.

Timothy D. Martin, PhD [Marion Abbe Fellow],
with his sponsor Stephen J. Elledge, PhD, at Brigham and Women’s Hospital, Boston, focuses on genomic instability, a hallmark of virtually all cancers that underlies the mutations and aneuploidy (incorrect chromosome number) changes that perturb oncogenes and tumor suppressor genes (TSGs). Patient tumor sequencing has unveiled common genomic alterations across different cancers. The goal of this project is to precisely recreate these genomic alterations and directly test how each contributes to oncogenesis.

Mandy M. Muller, PhD [HHMI Fellow],
with her sponsor Britt Glaunsinger, PhD, at the University of California, Berkeley, is examining Kaposi’s sarcoma-associated herpesvirus (KSHV), a virus associated with lifelong infections. A healthy immune system keeps the virus in check; however, in immunocompromised individuals, KSHV is associated with a number of malignances, including Kaposi’s sarcoma (KS). KSHV dramatically manipulates the intracellular gene expression environment of its host cell. The defining characteristic is a near-global depletion of cytoplasmic mRNA called “host shutoff.” The goal of this research is to mechanistically delineate how the virus hijacks host factors to dampen gene expression in the cell.

Duy P. Nguyen, PhD [Connie and Bob Lurie Fellow],
with his sponsor James A. Wells, PhD, at the University of California, San Francisco, is analyzing the bacterial enzyme Cas9, which has emerged to be a versatile tool to manipulate the genome. He aims to develop an efficient method for selective delivery to and activation of Cas9 in cancer cells. The developed methodology will hopefully set the foundation for rapidly creating genetic models to interrogate signaling pathways implicated in cancer and to investigate novel drug screening approaches that identify new drug targets for cancer treatment.

Neel H. Shah, PhD,
with his sponsor John Kuriyan, PhD, at the University of California, Berkeley, aims to elucidate structural details of the signaling enzyme ZAP-70, found primarily in immune T cells. Expression of ZAP-70 in other immune cells, B cells, however, is associated with chronic lymphocytic leukemia. Furthermore, loss of ZAP-70 function causes severe combined immunodeficiency; an impaired immune system can increase a patient’s susceptibility to tumor development. His research on ZAP-70 structure and function will help lay the groundwork for the development of ZAP-70-specific therapeutics.

Hume Akahori Stroud, PhD [HHMI Fellow],
with his sponsor Michael E. Greenberg, PhD, at Harvard Medical School, Boston, is examining the distinct role of MeCP2, a protein that binds methyl-CpG-DNA and regulates neuronal chromatin, which “packages” DNA. The proposed research has significant implications for causes and mechanisms of cancer, as dysregulation of DNA methylation and other chromatin modifications represent early oncogenic events in a wide range of human cancers.

Tony Yu-Chen Tsai, PhD, MD [Kenneth G. and Elaine A. Langone Fellow],
with his sponsor Sean G. Megason, PhD, at Harvard Medical School, Boston, seeks to understand how the signaling pathway directed by the protein Sonic Hedgehog (Shh) regulates cell-cell adhesion molecules required for correct spatial organization of the neuro-epithelium. Abnormal Shh signaling is associated with several types of cancer, and aberrant regulation of cell-cell adhesion could lead to tumor metastasis. His findings may ultimately lead to understanding and prevention of metastasis in Shh-associated cancers.

Daniel E. Webster, PhD,
with his sponsor Louis M. Staudt, MD, PhD, at the National Cancer Institute, Bethesda, studies Diffuse Large B Cell Lymphoma (DLBCL), an aggressive cancer that hijacks the normal molecular mechanisms acting in immune B cells to drive malignant growth. Many genes have been studied as oncogenes or tumor suppressors in DLBCL, but a class of long non-coding RNAs (lncRNAs) remains largely unexplored for its function in this cancer. LncRNAs, once thought to be non-functional products of junk DNA, are now known to play an essential role in many biological processes. This research will discover oncogenic or tumor suppressive lncRNAs in DLBCL to uncover potential targets for cancer diagnosis or therapy.

Sungwook Woo, PhD [HHMI Fellow],
with his sponsor Peng Yin, PhD, at Harvard University, Cambridge, is using protein structures to illustrate the mechanisms of cancer-related processes. His research aims to overcome limitations of current techniques by using recent breakthroughs in “programmable DNA self-assembly” to develop protein framework structures. If successful, his efforts will provide a general tool for structural biology and in turn benefit the mechanistic studies and therapeutic development for cancer.

####

DAMON RUNYON CANCER RESEARCH FOUNDATION

To accelerate breakthroughs, the Damon Runyon Cancer Research Foundation provides today’s best young scientists with funding to pursue innovative research.  The Foundation has gained worldwide prominence in cancer research by identifying outstanding researchers and physician-scientists.  Twelve scientists supported by the Foundation have received the Nobel Prize, and others are heads of cancer centers and leaders of renowned research programs.  Each of its award programs is extremely competitive, with less than 10% of applications funded.  Since its founding in 1946, Damon Runyon has invested nearly $275 million and funded more than 3,420 young scientists. This year, it will commit over $16 million in new awards to brilliant young investigators.

100% of all donations to the Foundation are used to support scientific research.  Its administrative and fundraising costs are paid from its Damon Runyon Broadway Tickets Service and endowment.

For more information visit www.damonrunyon.org

CONTACT
Yung S. Lie, PhD
Deputy Director and Chief Scientific Officer
Damon Runyon Cancer Research Foundation
yung.lie@damonrunyon.org
212.455.0521

 

 

July 9, 2014 > Comprehensive genomic analysis of lung cancer completed

Matthew L. Meyerson, MD, PhD (Damon Runyon Fellow ‘95-‘98) of Dana-Farber Cancer Institute and the Broad Institute, Cambridge, led a recent study by the NIH Cancer Genome Atlas project, which represents the most comprehensive genomic analysis of lung adenocarcinoma, a cancer that forms in the tissues near the outer parts of the lungs. Researchers identified 18 key mutations in an analysis of 230 patient lung tumors. This identified new potential drug targets and may also help physicians to determine which existing cancer treatments could be most effective in treating each individual patient. This study was published in the journal Nature.

Click here for more.

 

June 26, 2014 > New genetic tests recommended in patients with ALCL non-Hodgkin lymphoma

Andrew L. Feldman, MD (Damon Runyon Clinical Investigator ‘09-‘14), and colleagues at the Mayo Clinic, Rochester, reported that novel genetic tests can be used to determine the best treatment options for patients with anaplastic large-cell lymphoma (ALCL), a rare type of non-Hodgkin lymphoma. There are three subgroups of ALCL that have very different survival rates. These subgroups could not be differentiated by routine pathology but only with the aid of the genetic tests, which the researchers recommend giving to all patients with ALK-negative ALCL. Each patient’s treatment should then be tailored based on the subgroup of his/her disease. The study was published in the journal Blood.

Click here to read more and to view a video of Dr. Feldman. 

 

Damon Runyon Cancer Research Foundation Awards over $4M to 10 Top Young Clinical Investigators

Public release date: 23-June-2014

New York, NY (June 23, 2014)  - The Damon Runyon Cancer Research Foundation named seven new Damon Runyon Clinical Investigators at its spring 2014 Clinical Investigator Award Committee review. The recipients of this prestigious three-year award are outstanding early career physician-scientists conducting patient-oriented cancer research at major research centers under the mentorship of the nation’s leading scientists and clinicians. Each will receive $450,000 to support the development of his/her cancer research program.

The Foundation also awarded Continuation Grants to three Damon Runyon Clinical Investigators. Each award will provide an additional two years of funding totaling $300,000. The Continuation Grant is designed to support Clinical Investigators who are approaching the end of their original awards and need extra time and funding to complete a promising avenue of research or initiate/continue a clinical trial. This program is possible through the generous support of the William K. Bowes, Jr. Foundation, and Connie and Robert Lurie.

The Clinical Investigator Award program is specifically intended to help address the shortage of physicians capable of translating scientific discovery into new breakthroughs for cancer patients. In partnerships with industry sponsors and through its new Accelerating Cancer Cures initiative, the Damon Runyon Cancer Research Foundation has committed nearly $49 million to support the careers of 77 physician-scientists across the United States since 2000.

2014 Clinical Investigator Awardees

Arash Ash Alizadeh, MD, PhD
Diffuse Large B-cell Lymphoma (DLBCL) is the most common aggressive lymphoma in adults.  Unfortunately, current therapies typically fail in nearly half of these patients. Dr. Alizadeh proposes a novel treatment strategy for this disease: to characterize and isolate premalignant stem cells before they transform into cancer cells. He has found that expression of a single oncogene called BCL6 is capable of reprogramming these cells from normal cells to aggressive malignant cells. He aims to define the specific genetic alterations that can give rise to this cell reprogramming. This research will be important both for understanding cancer biology, as well as for developing more effective means for treatment of lymphoma patients.

Dr. Alizadeh works under the mentorship of Ronald Levy, MD, at the Stanford University School of Medicine, Stanford, California.

Joshua Brody, MD
Dr. Brody aims to develop a novel treatment approach for patients with advanced-stage lymphoma, by which the patient’s immune system is trained to recognize and eliminate his/her own cancer.  This approach, an “in situ vaccine,” recruits and activates specific immune cells, dendritic cells (DC), at the location of the treated tumor—where they can then educate the rest of the immune system to recognize and eliminate tumors throughout the body. The first patients enrolled on this clinical trial have already shown the recruitment and activation of DC within the treated tumor as well as regressions of lymphoma at sites distant from the treated site. The in situ vaccine will initially be tested in patients with low-grade lymphoma, with the goal of quickly expanding to other tumor types including melanoma and head and neck cancer.

Dr. Brody works under the mentorship of Nina Bhardwaj, MD, PhD, and Miriam Merad, MD, PhD, at The Icahn School of Medicine at Mount Sinai Hospital, New York, New York.

Lihua Elizabeth Budde, MD, PhD [The Jake Wetchler Foundation for Innovative Pediatric Cancer Research Clinical Investigator]
Hematopoietic stem cell transplant is the preferred and only curative treatment for most patients with acute myeloid leukemia (AML); however, a significant percentage of patients will eventually relapse. A novel effective therapy option is therefore urgently needed. Dr. Budde is testing a new strategy that uses patients’ own immune T cells, which have been modified to specifically target and kill leukemia cells. She will direct a Phase 1 clinical trial using these modified immune T cells as therapeutics for patients with AML. She is also developing ways to enhance the potency of these modified immune cells in killing leukemia cells. This therapeutic approach has the potential to change the treatment paradigm and may significantly improve the cure rate for patients with leukemia.

Dr. Budde works under the mentorship of Stephen J. Forman, MD, FACP, at City of Hope, Duarte, California.

Alejandro Gutierrez, MD
It remains unclear why some patients’ tumors can be cured with chemotherapy, whereas other tumors that appear to be nearly identical are completely chemoresistant. Dr. Gutierrez focuses on this issue in a particularly high-risk subset of T-cell acute lymphoblastic leukemia, a disease that most commonly affects older children and young adults. His goals are to define the molecular basis of resistance to conventional chemotherapy in patients with this disease, and to leverage this knowledge to develop a therapeutic strategy to restore chemosensitivity. Ultimately, this could lead to significant improvements in clinical outcome for these patients.

Dr. Gutierrez works under the mentorship of Stuart H. Orkin, MD, and Anthony Letai, MD, PhD, at Boston Children’s Hospital, Boston, Massachusetts.

Peter S. Hammerman, MD, PhD
Despite the initial success of targeted therapies for cancer, these treatments have limited efficacy in most diseases. Recent studies have shown that the immune cells that infiltrate a tumor play an active role in dictating the response to therapy; specific new therapies can augment the ability of the immune system to fight a cancer in combination with conventional therapies. Dr. Hammerman is using lung cancer as a model to explore genome-scale approaches to dissect this complex relationship between the tumor and its immune microenvironment. The goal of this research is to better define the optimal types of therapy for lung cancer by combining drugs that target the genetic alterations found in the tumor with those aimed at enhancing the immune response to the cancer, and to translate these findings into clinical practice.

Dr. Hammerman works under the mentorship of Glenn Dranoff, MD, Stephen F. Hodi, MD, and Kwok-Kin Wong, MD, PhD, at Dana-Farber Cancer Institute, Boston, Massachusetts.

Luc G. Morris, MD
Head and neck cancer is a lethal malignancy that can arise in the mouth, throat, voice box, and related areas. These tumors are squamous cell cancers that are, in many cases, caused by tobacco use or human papillomavirus (HPV) infection. Head and neck cancers have many molecular similarities with squamous cell cancers of the lung and esophagus. Dr. Morris is studying several poorly-understood genes that have been recently observed to be frequently altered in head and neck cancer (as well as lung and esophageal cancer). He has found that several of these genes act as tumor suppressor genes and in their normal state, prevent tumor development. In this project, he will determine the effects of these various gene alterations on tumor growth, cancer cell survival, and the clinical prognosis of patients. This work will help to develop new ways of therapeutically targeting the pathways that promote the development of head and neck and other tobacco and HPV-associated squamous cell cancers.

Dr. Morris works under the mentorship of Timothy Chan, MD, PhD, and James A. Fagin, MD, at Memorial Sloan Kettering Cancer Center, New York, New York.

Stephen T. Oh, MD, PhD [Doris Duke-Damon Runyon Clinical Investigator]
Myeloproliferative neoplasms (MPNs) are a group of blood cancers in which a malignant cell population proliferates out of control. Myelofibrosis (MF) is one type of MPN in which the bone marrow becomes replaced by scar tissue, leading to progressive failure of normal blood cell functions and ultimately death, on average five years after initial diagnosis. MPNs, including MF, can evolve to secondary acute myeloid leukemia (sAML), which is almost invariably fatal. There is no reliable curative treatment currently available for MPNs or MF. Targeted inhibitors of a protein called JAK2 provide significant symptomatic benefit for MF patients. However, these treatments do not cure the disease, nor has it been shown that they can prevent or delay progression to sAML. Dr. Oh aims to investigate the cellular abnormalities that underlie these blood cancers. These studies have the potential to lead to the development of improved treatments for MPNs.

Dr. Oh works under the mentorship of Daniel Link, MD, at Washington University, St. Louis, Missouri. 

 

2014 Clinical Investigator Continuation Grants


Marie Bleakley, MD [Richard Lumsden Foundation Investigator]

Bone marrow transplantation, or allogeneic hematopoietic stem cell transplant (HCT), is the only curative therapy for many patients with leukemia. Certain immune cells, called T cells, contained in the donor HCT graft can cause a “graft versus leukemia” (GVL) effect which eliminates leukemic cells. Unfortunately, there are also donor T cells in the HCT graft that can cause a condition called “graft versus host disease” (GVHD). GVHD is a life-threatening immune response that remains the major barrier to the success of transplantation. Dr. Bleakley is developing new approaches to separate the beneficial GVL effect from detrimental GVHD after bone marrow transplantation. She has identified specific subsets of immune cells that promote GVHD; these cells can then be eliminated to reduce the frequency or severity of GVHD, while at the same time maintaining and improving the GVL effect. The Continuation Grant will be used to move this study to the clinical trial phase. 

Dr. Bleakley works under the mentorship of Stanley R. Riddell, MD, at the Fred Hutchinson Cancer Research Center, Seattle, Washington. 

Zsofia K. Stadler, MD
Dr. Stadler is a clinical geneticist whose research goal is to determine the genetic basis of “sporadic” cancers in young adults. She is testing the hypothesis that de novo (spontaneous) chromosomal changes in the genome are associated with testicular germline cancer. The Continuation Grant will be used to apply high-resolution sequencing technology to compare the whole genomes of patients to those of their parents, with the goal of identifying rare genetic variants associated with cancer susceptibility and risk. This approach represents a new paradigm in cancer genetics, which could have broad applications in terms of cancer risk stratification and cancer prevention.

Dr. Stadler works under the mentorship of Kenneth Offit, MD, MPH, and Michael H. Wigler, PhD, at Memorial Sloan Kettering Cancer Center, New York, New York.

Jean Y. Tang, MD, PhD
Basal cell carcinoma (BCC) is the most common type of skin cancer. Mutations in the Hedgehog (HH) signaling pathway are frequently found in these cancers. Early-stage clinical studies of a HH pathway inhibitor drug have been successful, with 55% of patients reported to respond.  However, most tumors develop drug resistance during the course of therapy. Dr. Tang has characterized mechanisms of drug resistance and is working to identify new drug combinations that are effective in treatment of BCC. The Continuation Grant will enable her to move her findings on resistance to clinical trials in patients. Her studies have the potential to benefit patients with BCC as well as those with other HH-dependent cancers, such as medulloblastoma.

Dr. Tang works under the mentorship of Philip A. Beachy, PhD, and Ervin H. Epstein, MD, at Stanford University, Stanford, California. 

###

DAMON RUNYON CANCER RESEARCH FOUNDATION

 

To accelerate breakthroughs, the Damon Runyon Cancer Research Foundation provides today’s best young scientists with funding to pursue innovative research. The Foundation has gained worldwide prominence in cancer research by identifying outstanding researchers and physician-scientists. Twelve scientists supported by the Foundation have received the Nobel Prize, seven others have received National Medals of Science, and 65 have been elected to the National Academy of Sciences. Since its founding in 1946, Damon Runyon has invested nearly $275 million and funded more than 3,420 young scientists.

100% of all donations to the Foundation are used to support cutting-edge scientific research. Its administrative and fundraising costs are paid from its Damon Runyon Broadway Tickets and endowment.

For more information visit www.damonrunyon.org.


CONTACT
Yung S. Lie, PhD
Chief Scientific Officer
Damon Runyon Cancer Research Foundation
yung.lie@damonrunyon.org
212.455.0521

 

Damon Runyon, Sohn Conference Foundations Name 3 New Pediatric Cancer Research Fellows

New York, Memphis, Boston scientists receive prestigious awards to tackle cancers in children and young adults

New York, NY (June 20, 2014) – The Damon Runyon Cancer Research Foundation has named three outstanding young scientists as recipients of the prestigious Damon Runyon-Sohn Pediatric Cancer Research Fellowship Award, committing nearly $625,000 to help address a critical shortage of funding for pediatric cancer research.

The Fellowship Award provides funding to basic scientists and clinicians who conduct research with the potential to significantly impact the prevention, diagnosis or treatment of one or more pediatric cancers. Each recipient receives a four-year award ($248,000 for physician-scientists, $208,000 for basic scientists). Since 2012, this award has supported ten innovative pediatric cancer researchers.

The Sohn Conference Foundation, dedicated to curing pediatric cancers, announced in 2012 that it was granting $1.5 million to the Damon Runyon Cancer Research Foundation, the leading charity supporting innovative young cancer researchers, to establish the award.  With the generous support of the Pershing Square Sohn Cancer Research Alliance, the Fellowship Award continues to receive funding and recognition within the philanthropic community. 

2014 Damon Runyon-Sohn Fellows

 

Ly P. Vu, PhD, with her sponsors Michael Kharas, PhD, and Ross L. Levine, MD, at Memorial Sloan Kettering Cancer Center, New York, New York, is studying childhood acute myeloid leukemia (AML). Despite exciting advances in our understanding of AML and the availability of more aggressive treatment regimens, approximately 30% of children still eventually relapse from this disease. There are yet no approved targeted therapies for children with AML. Her project aims to uncover the role of Syncrip, a novel RNA binding protein, in maintaining the leukemia stem cell in AML. The study will provide insights into the mechanisms underlying the cause and development of AML and may lead to innovative therapeutic strategies and improved clinical outcomes for this deadly childhood disease.

David W. Woessner, PhD, with his sponsor Charles G. Mullighan, MBBS, MD, at St. Jude Children’s Research Hospital, Memphis, Tennessee, seeks to identify genetic changes that cause the most common type of childhood cancer, acute lymphoblastic leukemia (ALL). There are multiple subtypes of ALL, each with distinct genetic changes that drive disease development and influence success or failure of treatment. He has sequenced the genomes of over 1000 tumor cells from children with ALL and identified several hundred repeatedly mutated genes, for which the functions are currently unknown. He will test the role of these changes in ALL. A better understanding of which genetic changes significantly impact cancer behavior in ALL will provide new targets for existing therapy and/or avenues for development of new drug treatments for children with ALL.

Mark W. Zimmerman, PhD, with his sponsor A. Thomas Look, MD, at the Dana-Farber Cancer Institute, Boston, Massachusetts, studies neuroblastoma, a type of brain tumor that remains a challenging and often devastating condition despite many recent advances in its clinical management. In high-risk neuroblastoma tumors, which account for 15% of all childhood cancer deaths, the CHD5 gene is often deleted and its loss is associated with poor prognosis. CHD5 has emerged as a very attractive target for potential anti-cancer therapeutics. His research elucidating the CHD5 pathway will lead to significant advances in our understanding of how CHD5 functions as a tumor suppressor and the potential ways it could be targeted for anti-cancer therapy.

 

“These are some of the best young scientists working in pediatric research today, and they’re at a critical juncture in their careers,” says William Carroll, MD, chair of the Damon Runyon-Sohn Pediatric Cancer Fellowship Committee and Director of the New York University Cancer Institute. “They need our financial support, and we need their brilliant minds focused on curing childhood cancers. That is why this award is so important.”

Because cancer occurs less frequently in children and young adults than in the adult population, it does not receive significant funding from either the National Cancer Institute (only four percent of its budget) or the biopharmaceutical industry. As a result, there have been limited advances in recent years in treating these cancers, and fewer scientists are working in this field.

“I am inspired by Damon Runyon’s dedication to supporting excellent young scientists who are dedicating themselves to cancer research,” says Evan Sohn of the Sohn Conference Foundation. “Our Foundation is investing in this unique fellowship because it has the potential to change how cancer care is provided to children and young adults.” 

About The Sohn Conference Foundation

The Foundation was established in memory of Ira Sohn, a Wall Street professional whose life was cut short when he passed away from cancer. For more than fifteen years, the Foundation has raised funds for pediatric cancer research through its highly respected annual investment conference, the Sohn Investment Conference, which features many of Wall Street’s best and most successful investors. Thanks to the dedication of the conference founders, esteemed speakers, volunteers, and generous donors, the Foundation has invested more than $20 million in innovative research and institutions at the forefront of cancer research and pediatric care.

About the Pershing Square Sohn Cancer Research Alliance

The Pershing Square Sohn Cancer Research Alliance was formed in October 2013 by The Pershing Square Foundation and The Sohn Conference Foundation and is dedicated to playing a catalytic role in accelerating cures for cancer by enabling the pursuit of the most innovative and advanced cancer research and by facilitating partnerships between science and business.

About the Damon Runyon Cancer Research Foundation

To accelerate breakthroughs, the Damon Runyon Cancer Research Foundation provides today’s best young scientists with funding to pursue innovative research.  Twelve scientists supported by the Foundation have received the Nobel Prize, seven have received National Medals of Science, and 65 have been elected to the National Academy of Sciences, the science “Hall of Fame.”

Since its founding in 1946, Damon Runyon has invested nearly $275 million and funded more than 3,420 young scientists.  100% of all donations to the Foundation are used to support cutting-edge scientific research.  Its administrative and fundraising costs are paid from Damon Runyon Broadway Tickets and its endowment.

For more information, visit http://www.damonrunyon.org.

CONTACT
Yung S. Lie, PhD
Deputy Director and Chief Scientific Officer
Damon Runyon Cancer Research Foundation
yung.lie@damonrunyon.org
212.455.0521

Jeremy Robinson-Leon
Media Contact
The Sohn Conference Foundation
jrobinsonleon@groupgordon.com
212.784.5702

James Frayne
Media Contact
Pershing Square Sohn Cancer Research Alliance
jfrayne@rubenstein.com
212.843.8591 

 

2014 Annual Breakfast Honoring Steven Kandarian Raises $1.6 Million


New York, NY (June 5, 2014) The Damon Runyon Cancer Research Foundation honored Steven A. Kandarian, CEO of MetLife and Damon Runyon Board of Directors member, at its 2014 Annual Breakfast, held on Tuesday morning at Cipriani 42nd Street in New York City. The Breakfast raised more than $1.6 million to support the nation’s most brilliant young cancer researchers, pursuing work that promises to accelerate cures.

Alan M. Leventhal, Chairman of the Damon Runyon Board, welcomed guests to a program that included research updates from Himisha Beltran, MD, a Damon Runyon -Gordon Family Clinical Investigator at Weill Cornell Medical College pursuing personalized treatments for drug-resistant prostate cancer, and Adam de la Zerda, PhD, a Damon Runyon-Dale F. Frey Scientist at Stanford University working on improved imaging techniques to detect and destroy individual cancer cells.

The event’s keynote speaker was James E. Rothman, PhD, recipient of the 2013 Nobel Prize in Physiology or Medicine for work he began as a Damon Runyon Fellow from 1976 to 1978. Dr. Rothman reflected on how the early days of his career set a course for later success, noting “Damon Runyon was there for me when I wanted to take risks…I was trying to take on a major problem most people felt couldn’t be addressed.”

Dr. Rothman went on to praise the Foundation’s approach to cancer research, saying “By illuminating a broader swath of biology, researchers can have an unexpected impact. Some of the biggest discoveries are made this way.”

The morning’s honoree, Steven A. Kandarian, was introduced by Bruce E. Mosler, CEO of Cushman & Wakefield and Kandarian’s longtime friend. Damon Runyon Board of Directors member Sanford W. Morhouse, Esq. announced that Chao Lu, PhD, would be named the first Damon Runyon-Kandarian Family Fellow in recognition of Kandarian’s numerous contributions to Damon Runyon’s mission.

The Breakfast concluded with remarks from Kandarian, who spoke about cancer’s impact on his own family and his motivations for joining the Damon Runyon Board. “I was stunned by the swift and terrible power of cancer,” Kandarian said of the disease’s impact on his own family. “I can think of no better target for the intellectual energies of our most creative young researchers than this disease.”


DAMON RUNYON CANCER RESEARCH FOUNDATION

To accelerate breakthroughs, the Damon Runyon Cancer Research Foundation provides today’s best young scientists with funding to pursue innovative research. The Foundation has gained worldwide prominence in cancer research by identifying outstanding researchers and physician-scientists. Twelve scientists supported by the Foundation have received the Nobel Prize, seven others have received National Medals of Science, and 65 have been elected to the National Academy of Sciences.

Since its founding in 1946, Damon Runyon has invested nearly $275 million and funded more than 3,420 young scientists.  One hundred percent of all donations to the Foundation are used to support cutting-edge scientific research. Its administrative and fundraising costs are paid from its Damon Runyon Broadway Tickets and endowment.


CONTACT

Kim Kubert
Damon Runyon Cancer Research Foundation
212.455.0501
kim.kubert@damonrunyon.org 

June 2, 2014 > Immunotherapy extends long-term survival of melanoma patients

Jedd D. Wolchok, MD, PhD (Damon Runyon-Lilly Clinical Investigator ‘03-‘08) at Memorial Sloan Kettering Cancer Center, New York, and colleagues, reported the results of an ongoing clinical trial evaluating the safety and activity of combined immunotherapies for treatment of advanced melanoma. Nivolumab (anti-PD-1), an investigational PD-1 immune checkpoint inhibitor, and ipilimumab (anti-CTLA-4; Yervoy), were given either concurrently or sequentially to these patients. The two-year overall survival rate was 88%. Only several years ago, the two-year survival rate for metastatic melanoma may have been less than 10 percent. These results were reported at the annual meeting of the American Society of Clinical Oncology and featured in The New York Times.

Click here and here for more.

 

May 8, 2014 > Nanotechnology based drug delivery system developed

Eranthie Weerapana, PhD (Damon Runyon-Rachleff Innovator ‘12-‘14) and colleagues at Boston College, Chestnut Hill, have developed new nanotechnology “cage” that can entrap small molecule drugs and infiltrate cancer cells. This is a promising drug delivery system that could be used to fight cancer and other diseases. The results were published in the American Chemical Society journal ACSNano.

Click here for more.

 

New Discoveries eNewsletter:  Jan - April 2014

Damon Runyon Cancer Research Foundation | New Discoveries Newsletter

 

Damon Runyon Logo
January-April 2014

Damon Runyon Newsletter

Dear Damon Runyon Scientists,

We started off the year by announcing the newest awardees of the Fellowship, Breakthrough Scientist and Innovation Awards: 26 awards were granted, totaling nearly $5.1 million. Our Scientific Committees are meeting this spring to select the recipients of the 2014 Damon Runyon Clinical Investigator Award, Damon Runyon Fellowship Award and Damon Runyon-Sohn Pediatric Cancer Fellowship Award. Stay tuned for the announcement of these new awardees in the summer.

We’re also pleased to let you know that we held our third Accelerating Cancer Cures Research Symposium, focused on rebuilding the ranks of physician-scientists specially trained to translate laboratory discoveries into the clinic. The event, held at Genentech in South San Francisco on March 11, brought together Damon Runyon Clinical Investigators and Innovators, Award Committee and Board Members with scientists from leading pharmaceutical companies, including Genentech, Eli Lilly and Company, Celgene, Merck, Pfizer, and Takeda Pharmaceuticals International Co. The goal of Accelerating Cancer Cures is to eliminate barriers to progress by fostering communication and collaboration between academia and industry.

On Thursday, April 3, more than 650 people climbed to the top of 4 World Trade Center in New York City to raise nearly $175,000 for Damon Runyon scientists. Many thanks to our local area scientists who climbed 72 floors to support Damon Runyon!

Please see below for the latest update on exciting news and findings from your fellow Damon Runyon scientists – current and former. These are just the publications and awards that we are aware of, so we apologize if we have not included your work. Lay summaries of some of this work are posted on the News page of our website, along with additional news about our Scientific Committee and Board members.

Thanks again to those of you who have sent us updates on your recent progress. Please continue to stay in touch.

Best regards,
Yung

Yung S. Lie, PhD
Chief Scientific Officer



UPCOMING DEADLINES and EVENTS

Damon Runyon-Rachleff Innovation Award
Next application deadline: July 1

Dale F. Frey Award for Breakthrough Scientists
Next application deadline: July 15

Fellowship Award
Next application deadline: August 15

Runyon 5K at Yankee Stadium
Save the date: August 3
Join us for the sixth annual Runyon 5K, a unique cancer research fundraising run/walk that uses Yankee Stadium as its course. Run or walk the concourses and ramps, climb stairs between levels, and take your own victory laps around the warning track that circles the field. We welcome participation from you, our scientists, and please tell your family and friends! Registration will open in mid-May.



AWARDS and HONORS

 

2014 AACR Awards:
Elaine V. Fuchs, PhD (Damon Runyon Board Member), The Rockefeller University, New York
Jedd D. Wolchok, MD, PhD (Damon Runyon-Lilly Clinical Investigator ’03-’08), Memorial Sloan-Kettering Cancer Center, New York

2014 Alan T. Waterman Award of the National Science Foundation:
Feng Zhang, PhD (Innovator ’12- ’14), The Broad Institute of MIT and Harvard, Cambridge

2014 Norman Hackerman Award of the Welch Foundation
Benjamin P. Tu, PhD (Innovator ’11-’13), University of Texas Southwestern Medical School, Dallas

2013 Meyenburg Cancer Research Award:
Nathanael S. Gray, PhD (Innovator ’08-’10),
Dana-Farber Cancer Institute, Boston

Alumni Achievement Award from George Washington University:
Ariel C. Hollinshead, PhD (Grantee, ’63), George Washington University Medical Center, DC



NEW APPOINTMENTS and PROMOTIONS

Sean C. Bendall, PhD (Dale Frey Scientist ’14-’16)
Assistant Professor
Department of Pathology
Stanford University, Stanford

Anders M. Lindroth, PhD (Fellow 01-04)
Associate Professor
System Cancer Science
National Cancer Center, Seoul

Muneesh Tewari, MD, PhD (Innovator ’09-’11)
Associate Professor
University of Michigan, Ann Arbor

Yi Zhang, MD, PhD (Innovator ’09-’11)
Associate Professor
Microbiology and Immunology
Temple University, Philadelphia



PUBLICATIONS

Omar Abdel-Wahab, MD (Edward P. Evans Foundation Clinical Investigator ’13-’16), Memorial Sloan Kettering Cancer Center, New York
Efficacy of intermittent combined RAF and MEK inhibition in a patient with concurrent BRAF and NRAS mutant malignancies. Abdel-Wahab O, Klimek VM, Gaskell A, Viale A, Cheng D, Kim E, Rampal R, Bluth M, Harding JJ, Callahan MK, Merghoob T, Berger MF, Solit DB, Rosen N, Levine RL, Chapman PB. Cancer Discov. 2014 Mar 3.

Sean Bendall, PhD (Dale Frey Scientist ’14-’16), Stanford University, Stanford
Multiplexed ion beam imaging of human breast tumors. Angelo M, Bendall SC, Finck R, Hale MB, Hitzman C, Borowsky AD, Levenson RM, Lowe JB, Liu SD, Zhao S, Natkunam Y, Nolan GP. Nat Med. 2014 Apr;20(4):436-42.

Jelena Bezbradica, PhD (HHMI Fellow ’08-’11), University of Queensland, Brisbane
A role for the ITAM signaling module in specifying cytokine-receptor functions. Bezbradica JS, Rosenstein RK, Demarco RA, Brodsky I, Medzhitov R. Nat Immunol. 2014 Mar 9. doi: 10.1038/ni.2845.

Joseph A. Califano, III, MD (Damon Runyon Clinical Investigator ’01-’06),  and Christine H. Chung, MD (Damon Runyon-Lilly Clinical Investigator ’05-’10), The Johns Hopkins University, Baltimore
Activation of the NOTCH pathway in head and neck cancer. Sun W, Gaykalova DA, Ochs MF, Mambo E, Arnaoutakis D, Liu Y, Loyo M, Agrawal N, Howard J, Li R, Ahn S, Fertig E, Sidransky D, Houghton J, Buddavarapu K, Sanford T, Choudhary A, Darden W, Adai A, Latham G, Bishop J, Sharma R, Westra WH, Hennessey P, Chung CH, Califano JA. Cancer Res. 2014 Feb 15;74(4):1091-104. doi: 10.1158/0008-5472.CAN-13-1259.

Joseph A. Califano, III, MD (Damon Runyon Clinical Investigator ’01-’06), The Johns Hopkins University, Baltimore
Expression Microarray Analysis Reveals Alternative Splicing of LAMA3 and DST Genes in Head and Neck Squamous Cell Carcinoma. Li R, Ochs MF, Ahn SM, Hennessey P, Tan M, Soudry E, Gaykalova DA, Uemura M, Brait M, Shao C, Westra W, Bishop J, Fertig EJ, Califano JA. PLoS One. 2014 Mar 27;9(3):e91263. doi: 10.1371/journal.pone.0091263.

Andrew T. Chan, MD, MPH (Clinical Investigator ’08-’13), Massachusetts General Hospital, Boston
Aspirin Use, 8q24 Single Nucleotide Polymorphism rs6983267, and Colorectal Cancer According to CTNNB1 Alterations. Nan H, Morikawa T, Suuriniemi M, Imamura Y, Werner L, Kuchiba A, Yamauchi M, Hunter DJ, Kraft P, Giovannucci EL, Fuchs CS, Ogino S, Freedman ML, Chan AT. J Natl Cancer Inst. 2013 Dec 18;105(24):1852-61. doi: 10.1093/jnci/djt331. Epub 2013 Dec 7.

Measures of Adiposity Are Associated with Increased Risk of Peptic Ulcer. Boylan MR, Khalili H, Huang ES, Chan AT. Clin Gastroenterol Hepatol. 2014 Mar 26.

Joint effects of colorectal cancer susceptibility Loci, circulating 25-hydroxyvitamin d and risk of colorectal cancer. Hiraki LT, Joshi AD, Ng K, Fuchs CS, Ma J, Hazra A, Peters U, Karlson EW, Giovannucci E, Kraft P, Chan AT. PLoS One. 2014 Mar 26;9(3):e92212.

Sarat Chandarlapaty, MD, PhD (Patterson Trust Clinical Investigator ’12-’15), Memorial Sloan-Kettering Cancer Center, New York
Rapid Induction of Apoptosis by PI3K Inhibitors Is Dependent upon Their Transient Inhibition of RAS-ERK Signaling. Will M, Qin AC, Toy W, Yao Z, Rodrik-Outmezguine V, Schneider C, Huang X, Monian P, Jiang X, de Stanchina E, Baselga J, Liu N, Chandarlapaty S, Rosen N. Cancer Discov. 2014 Mar;4(3):334-47.

Sidi Chen, PhD (Fellow ’12-’14), Massachusetts Institute of Technology, Cambridge
Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype. Yin H, Xue W, Chen S, Bogorad RL, Benedetti E, Grompe M, Koteliansky V, Sharp PA, Jacks T, Anderson DG. Nat Biotechnol. 2014 Mar 30.

Heather R. Christofk, PhD (Innovator ’10-’12), University of California, Los Angeles
Adenovirus E4ORF1-Induced MYC Activation Promotes Host Cell Anabolic Glucose Metabolism and Virus Replication. Thai M, Graham NA, Braas D, Nehil M, Komisopoulou E, Kurdistani SK, McCormick F, Graeber TG, Christofk HR. Cell Metab. 2014 Apr 1;19(4):694-701.

Chiou-Fen Chuang, PhD (Fellow ’01-’04), Cincinnati Children’s Hospital Research Foundation, Cincinnati
Two distinct types of neuronal asymmetries are controlled by the Caenorhabditis elegans zinc finger transcription factor die-1. Cochella L, Tursun B, Hsieh YW, Galindo S, Johnston RJ, Chuang CF, Hobert O. Genes Dev. 2014 Jan 1;28(1):34-43. doi: 10.1101/gad.233643.113.

Ryan B. Corcoran, MD, PhD (Clinical Investigator ’12-’15), Massachusetts General Hospital, Charlestown
Inhibition of KRAS-Driven Tumorigenicity by Interruption of an Autocrine Cytokine Circuit. Zhu Z, Aref AR, Cohoon TJ, Barbie TU, Imamura Y, Yang S, Moody SE, Shen RR, Schinzel AC, Thai TC, Reibel JB, Tamayo P, Godfrey JT, Qian ZR, Page AN, Maciag K, Chan EM, Silkworth W, Labowsky MT, Rozhansky L, Mesirov JP, Gillanders WE, Ogino S, Hacohen N, Gaudet S, Eck MJ, Engelman JA, Corcoran RB, Wong KK, Hahn WC, Barbie DA. Cancer Discov. 2014 Apr;4(4):452-65.

mTOR inhibition specifically sensitizes colorectal cancers with KRAS or BRAF mutations to BCL-2/BCL-XL inhibition by suppressing MCL-1. Faber AC, Coffee EM, Costa C, Dastur A, Ebi H, Hata AN, Yeo AT, Edelman EJ, Song Y, Tam AT, Boisvert JL, Milano RJ, Roper J, Kodack DP, Jain RK, Corcoran RB, Rivera MN, Ramaswamy S, Hung KE, Benes CH, Engelman JA. Cancer Discov. 2014 Jan;4(1):42-52.

Robert N. Eisenman, PhD (Fellow ’70-’72), Fred Hutchinson Cancer Research Center, Seattle
Stress-induced cleavage of Myc promotes cancer cell survival. Conacci-Sorrell M, Ngouenet C, Anderson S, Brabletz T, Eisenman RN. Genes Dev. 2014 Apr 1;28(7):689-707.

William M. Grady, MD (Damon Runyon-Lilly Clinical Investigator ’02-’07), Fred Hutchinson Cancer Research Center, Seattle
Inactivation of TGF-β signaling and loss of PTEN cooperate to induce colon cancer in vivo. Yu M, Trobridge P, Wang Y, Kanngurn S, Morris SM, Knoblaugh S, Grady WM. Oncogene. 2013 Apr 22. doi: 10.1038/onc.2013.102.

John V. Heymach, MD, PhD (Damon Runyon-Lilly Clinical Investigator ’04-’07), M.D. Anderson Cancer Center, Houston
Tumor endothelial markers define novel subsets of cancer-specific circulating endothelial cells associated with antitumor efficacy. Mehran R, Nilsson M, Khajavi M, Du Z, Cascone T, Wu HK, Cortes A, Xu L, Zurita A, Schier R, Riedel B, El-Zein R, Heymach JV. Cancer Res. 2014 Mar 13.

Daniel F. Jarosz, PhD (HHMI Fellow ’08-’10), Stanford University School of Medicine, Stanford
Cryptic variation in morphological evolution: HSP90 as a capacitor for loss of eyes in cavefish. Rohner N, Jarosz DF, Kowalko JE, Yoshizawa M, Jeffery WR, Borowsky RL, Lindquist S, Tabin CJ. Science. 2013 Dec 13;342(6164):1372-5.

Björn F.C. Kafsack, PhD (HHMI Fellow ’10-’12), Princeton University, Princeton
A transcriptional switch underlies commitment to sexual development in malaria parasites. Kafsack BF, Rovira-Graells N, Clark TG, Bancells C, Crowley VM, Campino SG, Williams AE, Drought LG, Kwiatkowski DP, Baker DA, Cortés A, Llinás M. Nature. 2014 Feb 23.

William Y. Kim, MD (Damon Runyon-Merck Clinical Investigator ’11-’14), University of North Carolina, Chapel Hill
Intrinsic subtypes of high-grade bladder cancer reflect the hallmarks of breast cancer biology. Damrauer JS, Hoadley KA, Chism DD, Fan C, Tiganelli CJ, Wobker SE, Yeh JJ, Milowsky MI, Iyer G, Parker JS, Kim WY. Proc Natl Acad Sci U S A. 2014 Feb 11.

Anders M. Lindroth, PhD (Fellow 01-04), German Cancer Research Center, Heidelberg
Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas. Bender S, Tang Y, Lindroth AM, Hovestadt V, Jones DT, Kool M, Zapatka M, Northcott PA, Sturm D, Wang W, Radlwimmer B, Højfeldt JW, Truffaux N, Castel D, Schubert S, Ryzhova M, Seker-Cin H, Gronych J, Johann PD, Stark S, Meyer J, Milde T, Schuhmann M, Ebinger M, Monoranu CM, Ponnuswami A, Chen S, Jones C, Witt O, Collins VP, von Deimling A, Jabado N, Puget S, Grill J, Helin K, Korshunov A, Lichter P, Monje M, Plass C, Cho YJ, Pfister SM. Cancer Cell. 2013 Nov 11;24(5):660-72.

Recurrent H3.3 alterations in childhood tumors. Lindroth AM, Plass C. Nat Genet. 2013 Dec;45(12):1413-4.

Sarkis K. Mazmanian, PhD (Innovator ’08-’10), California Institute of Technology, Pasadena
Gut microbiota promote hematopoiesis to control bacterial infection. Khosravi A, Yáñez A, Price JG, Chow A, Merad M, Goodridge HS, Mazmanian SK. Cell Host Microbe. 2014 Mar 12;15(3):374-81.

Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Hsiao EY, McBride SW, Hsien S, Sharon G, Hyde ER, McCue T, Codelli JA, Chow J, Reisman SE, Petrosino JF, Patterson PH, Mazmanian SK. Cell. 2013 Dec 19;155(7):1451-63.

Akinyemi Ojesina (Rebecca Ridley Kry Fellow ’08-’11), Dana Farber Cancer Institute, Boston
Landscape of genomic alterations in cervical carcinomas. Ojesina AI, Lichtenstein L, Freeman SS, Pedamallu CS, Imaz-Rosshandler I, Pugh TJ, Cherniack AD, Ambrogio L, Cibulskis K, Bertelsen B, Romero-Cordoba S, Treviño V, Vazquez-Santillan K, Guadarrama AS, Wright AA, Rosenberg MW, Duke F, Kaplan B, Wang R, Nickerson E, Walline HM, Lawrence MS, Stewart C, Carter SL, McKenna A, Rodriguez-Sanchez IP, Espinosa-Castilla M, Woie K, Bjorge L, Wik E, Halle MK, Hoivik EA, Krakstad C, Gabiño NB, Gómez-Macías GS, Valdez-Chapa LD, Garza-Rodríguez ML, Maytorena G, Vazquez J, Rodea C, Cravioto A, Cortes ML, Greulich H, Crum CP, Neuberg DS, Hidalgo-Miranda A, Escareno CR, Akslen LA, Carey TE, Vintermyr OK, Gabriel SB, Barrera-Saldaña HA, Melendez-Zajgla J, Getz G, Salvesen HB, Meyerson M. Nature. 2013 Dec 25. doi: 10.1038/nature12881.

Bradley L. Pentelute, PhD (Innovator ’13-’15), Massachusetts Institute of Technology, Cambridge
Rapid flow-based Peptide synthesis. Simon MD, Heider PL, Adamo A, Vinogradov AA, Mong SK, Li X, Berger T, Policarpo RL, Zhang C, Zou Y, Liao X, Spokoyny AM, Jensen KF, Pentelute BL. Chembiochem. 2014 Mar 21;15(5):713-20.

John L. Rinn, PhD (Innovator ’09-’11), Harvard University, Cambridge
Topological organization of multichromosomal regions by the long intergenic noncoding RNA Firre. Hacisuleyman E, Goff LA, Trapnell C, Williams A, Henao-Mejia J, Sun L, McClanahan P, Hendrickson DG, Sauvageau M, Kelley DR, Morse M, Engreitz J, Lander ES, Guttman M, Lodish HF, Flavell R, Raj A, Rinn JL. Nat Struct Mol Biol. 2014 Feb;21(2):198-206.

Multiple knockout mouse models reveal lincRNAs are required for life and brain development. Sauvageau M, Goff LA, Lodato S, Bonev B, Groff AF, Gerhardinger C, Sanchez-Gomez DB, Hacisuleyman E, Li E, Spence M, Liapis SC, Mallard W, Morse M, Swerdel MR, D’Ecclessis MF, Moore JC, Lai V, Gong G, Yancopoulos GD, Frendewey D, Kellis M, Hart RP, Valenzuela DM, Arlotta P, Rinn JL. Elife. 2013 Dec 31;2:e01749.

Joel H. Rubenstein, MD, MSc (Gordon Family Clinical Investigator ’07-’10), University of Michigan, Ann Arbor
Systematic review with meta-analysis: race-specific effects of alcohol and tobacco on the risk of oesophageal squamous cell carcinoma. Prabhu A, Obi KO, Rubenstein JH. Aliment Pharmacol Ther. 2013 Nov;38(10):1145-55. doi: 10.1111/apt.12514.

Associations of diabetes mellitus, insulin, leptin, and ghrelin with gastroesophageal reflux and Barrett’s esophagus. Rubenstein JH, Morgenstern H, McConell D, Scheiman JM, Schoenfeld P, Appelman H, McMahon LF Jr, Kao JY, Metko V, Zhang M, Inadomi JM. Gastroenterology. 2013 Dec;145(6):1237-44.e1-5.

Association between Helicobacter pylori and Barrett’s esophagus, erosive esophagitis, and gastroesophageal reflux symptoms. Rubenstein JH, Inadomi JM, Scheiman J, Schoenfeld P, Appelman H, Zhang M, Metko V, Kao JY. Clin Gastroenterol Hepatol. 2014 Feb;12(2):239-45.

Jean Y. Tang, MD, PhD (Clinical Investigator ’11-’14), Stanford University, Stanford
Open-Label, Exploratory Phase II Trial of Oral Itraconazole for the Treatment of Basal Cell Carcinoma. Kim DJ, Kim J, Spaunhurst K, Montoya J, Khodosh R, Chandra K, Fu T, Gilliam A, Molgo M, Beachy PA, Tang JY. J Clin Oncol. 2014 Feb 3.

Cole Trapnell, PhD (Dale Frey Scientist ’14-’16), Harvard University, Cambridge
The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells. Trapnell C, Cacchiarelli D, Grimsby J, Pokharel P, Li S, Morse M, Lennon NJ, Livak KJ, Mikkelsen TS, Rinn JL. Nat Biotechnol. 2014 Apr;32(4):381-6.

Hyun Youk, PhD (HHMI Fellow ’11-’14), University of California, San Francisco
Secreting and sensing the same molecule allows cells to achieve versatile social behaviors. Youk H, Lim WA. Science. 2014 Feb 7;343(6171):1242782.

Dmitriy Zamarin, MD, PhD (Dr. Bart A. Kamen Fellow ’13-’15), Memorial Sloan Kettering Cancer Center, New York
D. Zamarin, R. B. Holmgaard, S. K. Subudhi, J. S. Park, M. Mansour, P. Palese, T. Merghoub, J. D. Wolchok, J. P. Allison, Localized Oncolytic Virotherapy Overcomes Systemic Tumor Resistance to Immune Checkpoint Blockade Immunotherapy. Sci. Transl. Med. 6, 226ra32 (2014).

© 2011 Damon Runyon. All Rights Reserved  |  Privacy policy

 

April 23, 2014 > Gene levels indicate whether aspirin effective in prevention of colorectal cancer

Andrew T. Chan, MD, MPH (Damon Runyon Clinical Investigator ‘08-‘13) of Massachusetts General Hospital, Boston, working with a multi-institutional team, analyzed data from two long-term studies involving nearly 128,000 participants. The researchers found that individuals whose colons have high levels of a specific gene, 15-hydroxyprostaglandin dehydrogenase (15-PGDH), dramatically reduce their chances of developing colorectal cancer by taking aspirin. In contrast, aspirin provides no benefit to individuals whose colons show low levels of 15-PGDH. This study will help physicians to determine which patients are likely to benefit from aspirin. The findings were published in the journal Science Translational Medicine and featured in The New York Times.

Click here and here for more.

 

April 20, 2014 > Novel cancer vaccine successful in Phase I clinical trial

Madhav Dhodapkar, MD (Damon Runyon-Lilly Clinical Investigator ‘02-‘07), Yale Cancer Center, New Haven, reported positive results from a Phase 1 clinical trial using a cancer vaccine called CDX-1401, which activates the patient’s immune system against cancers that express the tumor marker NY-ESO-1. In 45 patients with advanced malignancies (melanoma or non-small cell lung cancer), thirteen patients experienced stabilization of disease and two patients had tumor regression. Six of eight patients who received immune-checkpoint inhibitors such as Yervoy within 3 months after CDX-1401 administration had tumor regression. This study represents a promising approach for the next generation of vaccines against pathogens and cancer. The findings were published in Science Translational Medicine.

Click here for more.

 

Runyon Up Event Raises More than $174,000 for Cancer Research in First-Ever 4 WTC Stair Climb

More than 660 participants from 15 states climb 72 stories in historic event; 100% of donations support the nation’s most brilliant young scientists, pursuing cures for all forms of cancer

Runyon Up Stair Climb for Cancer Research

New York, NY (April 4, 2014) More than 700 people – from those affected by cancer to professional stair climbers – took part in the Damon Runyon Cancer Research Foundation’s first ever Runyon Up stair climb at the new 4 World Trade Center building on April 3rd, raising more than $173,000 for young cancer researchers.

Hundreds of corporate teams and individual participants, ranging in age from 14 to 71 years old, hailed from across New York City and from 15 states, from coast to coast. They climbed the new tower’s 72 stories – all 1,632 steps – over the course of nearly four hours in the evening event. The fastest male climber was Tim Donahue, 44, of Manhattan, NY, who took just 8 minutes and 56 seconds to climb 1,632 steps. The top female climber was Shari Klarfeld, 33, of Plainview, NY, who completed the climb in 11 minutes and 17 seconds.

“We thank Silverstein Properties for partnering with us at this historic moment in time. 4 World Trade Center is a symbol of innovation and resilience, and was an appropriate venue to champion commitment to the cutting-edge researchers who are making the medical breakthroughs of tomorrow,” said Lorraine W. Egan, President and Chief Executive Officer of the Damon Runyon Cancer Research Foundation. “All proceeds from Runyon Up will allow us to support the best and brightest young cancer researchers in the nation. Our participants help make life-saving discoveries.”

The first heat of elite climbers at this milestone event launched at 6:30pm, followed by heats of recreational climbers. Runyon Up offered three different registration options: Participants could climb to the 54th Floor or 72nd Floor, or opt for the virtual climb and take the elevator. Participants paid a $40 entry fee and raised at least $72 – $1 per floor of the building – in support of cancer research. Participants had their own online donation pages to make fundraising easy, and you can still support them until April 30th at www.runyonup.org.

Scientists funded by Damon Runyon also were on hand – with more than a half dozen participating in the event - to meet and congratulate participants. Participants included a retired police officer who worked at the 9/11 site, a group of firefighters from North Hunterdon, N.J., who climbed in full gear, parents, spouses and friends of those affected by cancer, professional stair climbers and marathoners.

The event marked a pivotal point in the history of the World Trade Center site. In November, officials held a ribbon-cutting at 4 World Trade Center, which will soon be the sixth-tallest building in New York City and recently was named Curbed’s Building of the Year. For most people, this was their first view inside the 2.3 million square foot building, which is not expected to see tenants – including the Port Authority of New York and New Jersey - until 2015.

As always, 100% of all donations raised by participants will directly support the nation’s most brilliant young scientists, pursuing cures for all forms of cancer. Damon Runyon holds a 5K inside Yankee Stadium each August, which has raised nearly $3 million to date.


SPONSORS
In addition to Silverstein Properties’ support, other event sponsors include CBRE, AIG, Bank of America Merrill Lynch, Pepsi, Cabot Creamery, Dave’s Hoagies, GoGo squeeZ, GuS – Grown-up Soda, SiriusXM Satellite Radio, SkinnyPop Popcorn, Utz, Vita Coco, Vita Organic Foods, and Whole Foods..

> View photos from the event 

> Read coverage from the New York Daily News.

> Read coverage from the Wall Street Journal.

> View more photos from the Associated Press

DAMON RUNYON CANCER RESEARCH FOUNDATION

To accelerate breakthroughs, the Damon Runyon Cancer Research Foundation provides today’s best young scientists with funding to pursue innovative research. The Foundation has gained worldwide prominence in cancer research by identifying outstanding researchers and physician-scientists. Twelve scientists supported by the Foundation have received the Nobel Prize, seven others have received National Medals of Science, and 65 have been elected to the National Academy of Sciences.

Since its founding in 1946, Damon Runyon has invested nearly $275 million and funded more than 3,420 young scientists.  One hundred percent of all donations to the Foundation are used to support cutting-edge scientific research. Its administrative and fundraising costs are paid from its Damon Runyon Broadway Tickets and endowment. For more information visit www.damonrunyon.org.


CONTACT

Kim Kubert
Damon Runyon Cancer Research Foundation
212.455.0501
kim.kubert@damonrunyon.org 

April 14, 2014 > 2014 National Science Foundation Award for young researchers

Feng Zhang, PhD (Damon Runyon-Rachleff Innovator ‘12-‘14), of the Broad Institute, Cambridge, was named the 2014 recipient of its Alan T. Waterman Award from the National Science Foundation (NSF). This award is NSF’s highest honor that recognizes an outstanding researcher under the age of 35 and funds his or her research in any field of science or engineering.

Click here for more.

 

April 2, 2014 > New technology to analyze proteins in cancer cells

Sean Bendall, PhD (Damon Runyon-Dale F. Frey Scientist ‘14-‘16, Damon Runyon Fellow ‘09-‘12), of Stanford University, Stanford, and colleagues, reported the development of a new technology that can simultaneously detect as many as 100 clinically important proteins in breast tumor cells-conventional methods can pinpoint only two to four at the same time. This technology, called multiplexed ion beam imaging (MIBI), will enable scientists to provide new insights into cancer cell development that will be valuable for basic research, drug discovery and clinical diagnostics. These results were published in the journal Nature Medicine.

Click here for more.

 

 <  1 2 3 4 >  Last »