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February 4, 2010 > Nuclear pore proteins found to regulate gene expression
Maya Capelson, PhD (Damon Runyon Fellow ‘07-‘10) in the laboratory of Martin W. Hetzer, PhD, at the Salk Institute for Biological Studies, La Jolla, identified a new function for nucleoporins, proteins of the nuclear pore complex. Until now, it was thought that the sole function of nuclear pore complexes is in transport of molecules in and out of the cell’s nucleus. These researchers demonstrated that nucleoporins are also present inside the nucleus where they bind DNA and regulate gene expression. Certain nucleoporins are overexpressed in leukemia, colon and lung cancers; this new finding may indicate the mechanism of how nucleoporins are linked to cancer. This research was published in the journal Cell.