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June 20, 2007
Eli Canaani, PhD (Damon Runyon Fellow '75) and colleagues at The Ohio State University, Columbus, Ohio, reported elevated levels of specific non-coding small RNAs, called miRNAs, in leukemias triggered by the fusion protein ALL-1 (also termed MLL). These miRNAs suppress the expression of target genes and may be implicated in leukemogenesis. Their findings were published in the prestigious journal, Proceedings of the National Academy of Science.