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June 25, 2010 > Virus plus genetic mutation promotes Crohn’s disease
Ken Cadwell, PhD (Lallage Feazel Wall Fellow ‘08-‘11) and colleagues at Washington University, St. Louis, reported that the combination of a genetic mutation in Atg16L1 plus a specific viral infection induces Crohn’s disease, an inflammatory disease of the gut. The mutation alone is not sufficient to promote the disease. In addition, their research suggests that the genetic and viral combination harms the gut microbial community. Treatment with an antibiotic clears out the gut microbes and eliminates disease symptoms in mice. This study indicates that viruses may play an important role in disease onset. These findings were published in the journal Cell.