Damon Runyon Cancer Resources

June 5, 2010 > Successful treatment for metastatic melanoma

Jedd D. Wolchok, MD, PhD (Damon Runyon-Lilly Clinical Investigator ‘03-‘08) of Memorial Sloan-Kettering Cancer Center, New York, and colleagues reported the first treatment to improve overall survival in patients with metastatic melanoma.  In a phase III clinical study, patients were treated with ipilimumab, which blocks a protein called CTLA-4 to promote an antitumor T-cell immune response.  Overall survival was improved by 34.4% (10.1 months vs. 6.4 months).  These findings were reported at the American Society of Clinical Oncology conference and in the New England Journal of Medicine.

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