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Eric J. Bennett, PhD (Fellow ’08-’11), University of California, San Diego
Defining human ERAD networks through an integrative mapping strategy. Christianson JC, Olzmann JA, Shaler TA, Sowa ME, Bennett EJ, Richter CM, Tyler RE, Greenblatt EJ, Wade Harper J, Kopito RR. Nat Cell Biol. 2011 Nov 27. doi: 10.1038/ncb2383.
N-terminal acetylation acts as an avidity enhancer within an interconnected multiprotein complex. Scott DC, Monda JK, Bennett EJ, Harper JW, Schulman BA. Science. 2011 Nov 4;334(6056):674-8.
Kate S. Carroll, PhD (Fellow ’03-’06), The Scripps Research Institute, Jupiter
Peroxide-dependent sulfenylation of the EGFR catalytic site enhances kinase activity. Paulsen CE, Truong TH, Garcia FJ, Homann A, Gupta V, Leonard SE, Carroll KS. Nat Chem Biol. 2011 Dec 11;8(1):57-64.
Howard Y. Chang, MD, PhD (Damon Runyon Scholar ’06-’08), Stanford University School of Medicine, Stanford
Genomic Maps of Long Noncoding RNA Occupancy Reveal Principles of RNA-Chromatin Interactions. Chu C, Qu K, Zhong FL, Artandi SE, Chang HY. Mol Cell. 2011 Nov 18;44(4):667-78.
Roger J. Davis, PhD (Fellow ’84-’85), University of Massachusetts Medical School, Worcester
MLK3 regulates bone development downstream of the faciogenital dysplasia protein FGD1 in mice. Zou W, Greenblatt MB, Shim JH, Kant S, Zhai B, Lotinun S, Brady N, Hu DZ, Gygi SP, Baron R, Davis RJ, Jones D, Glimcher LH. J Clin Invest. 2011 Nov 1;121(11):4383-92.
Ralph J. DeBerardinis, MD, PhD (Clinical Investigator ’11-’14), UT Southwestern Medical Center, Dallas
Reductive carboxylation supports growth in tumour cells with defective mitochondria. Mullen AR, Wheaton WW, Jin ES, Chen PH, Sullivan LB, Cheng T, Yang Y, Linehan WM, Chandel NS, Deberardinis RJ. Nature. 2011 Nov 20. doi: 10.1038/nature10642.
Channing J. Der, PhD (Fellow ’81-’83), University of North Carolina School of Medicine, Chapel Hill and Laura M. Machesky, PhD (Fellow ’93-’96), The Beatson Institute, Glasgow, Scotland
P-Rex1 is required for efficient melanoblast migration and melanoma metastasis. Lindsay CR, Lawn S, Campbell AD, Faller WJ, Rambow F, Mort RL, Timpson P, Li A, Cammareri P, Ridgway RA, Morton JP, Doyle B, Hegarty S, Rafferty M, Murphy IG, McDermott EW, Sheahan K, Pedone K, Finn AJ, Groben PA, Thomas NE, Hao H, Carson C, Norman JC, Machesky LM, Gallagher WM, Jackson IJ, Van Kempen L, Beermann F, Der C, Larue L, Welch HC, Ozanne BW, Sansom OJ. Nat Commun. 2011 Nov 22;2:555. doi: 10.1038/ncomms1560.
Victoria M. D’Souza, PhD (Scholar ’06-’09), Harvard University, Cambridge
An equilibrium-dependent retroviral mRNA switch regulates translational recoding. Houck-Loomis B, Durney MA, Salguero C, Shankar N, Nagle JM, Goff SP, D’Souza VM. Nature. 2011 Nov 27. doi: 10.1038/nature10657.
William S. Dynan, PhD (Fellow ’80-’82), Georgia Health Sciences University, Augusta
Intranuclear Delivery of a Novel Antibody-Derived Radiosensitizer Targeting the DNA-Dependent Protein Kinase Catalytic Subunit. Xiong H, Lee RJ, Haura EB, Edwards JG, Dynan WS, Li S. Int J Radiat Oncol Biol Phys. 2011 Dec 2.
Dean W. Felsher, MD, PhD (Damon Runyon-Lilly Clinical Investigator ’03-’08), Stanford University School of Medicine, Stanford
Survival and death signals can predict tumor response to therapy after oncogene inactivation. Tran PT, Bendapudi PK, Lin HJ, Choi P, Koh S, Chen J, Horng G, Hughes NP, Schwartz LH, Miller VA, Kawashima T, Kitamura T, Paik D, Felsher DW. Sci Transl Med. 2011 Oct 5;3(103):103ra99.
Harrison W. Gabel, PhD (Fellow ’10-’12), Harvard Medical School, Boston
Genome-wide activity-dependent MeCP2 phosphorylation regulates nervous system development and function. Cohen S, Gabel HW, Hemberg M, Hutchinson AN, Sadacca LA, Ebert DH, Harmin DA, Greenberg RS, Verdine VK, Zhou Z, Wetsel WC, West AE, Greenberg ME. Neuron. 2011 Oct 6;72(1):72-85.
Wendy S. Garrett, MD, PhD (Damon Runyon Fellow ’06-’09), Matthew L. Meyerson, MD, PhD (Damon Runyon Fellow ’95-’98), Akinyemi I. Ojesina, MBBS, PhD (Damon Runyon Fellow ’08-’11) and Ramesh A. Shivdasani, MD, PhD (Damon Runyon Scholar ’98-’99), Dana-Farber Cancer Institute and the Broad Institute, Cambridge
Genomic analysis identifies association of Fusobacterium with colorectal carcinoma. Kostic AD, Gevers D, Pedamallu CS, Michaud M, Duke F, Earl AM, Ojesina AI, Jung J, Bass AJ, Tabernero J, Baselga J, Liu C, Shivdasani RA, Ogino S, Birren BW, Huttenhower C, Garrett WS, Meyerson M. Genome Res. 2011 Oct 18.
Maura L. Gillison, MD, PhD (Damon Runyon-Lilly Clinical Investigator ’00-’05), The Ohio State University, Columbus
Human papillomavirus and rising oropharyngeal cancer incidence in the United States. Chaturvedi AK, Engels EA, Pfeiffer RM, Hernandez BY, Xiao W, Kim E, Jiang B, Goodman MT, Sibug-Saber M, Cozen W, Liu L, Lynch CF, Wentzensen N, Jordan RC, Altekruse S, Anderson WF, Rosenberg PS, Gillison ML. J Clin Oncol. 2011 Nov 10;29(32):4294-301.
William M. Grady, MD (Damon Runyon-Lilly Clinical Investigator ’02-’07), Fred Hutchinson Cancer Research Center, Seattle
Aberrantly methylated PKP1 in the progression of Barrett’s esophagus to esophageal adenocarcinoma. Kaz AM, Luo Y, Dzieciatkowski S, Chak A, Willis JE, Upton MP, Leidner RS, Grady WM. Genes Chromosomes Cancer. 2011 Dec 14.
Michael E. Greenberg, PhD (Fellow ’83-’84), Dana-Farber Cancer Institute, Boston
Cyclin E constrains Cdk5 activity to regulate synaptic plasticity and memory formation. Odajima J, Wills ZP, Ndassa YM, Terunuma M, Kretschmannova K, Deeb TZ, Geng Y, Gawrzak S, Quadros IM, Newman J, Das M, Jecrois ME, Yu Q, Li N, Bienvenu F, Moss SJ, Greenberg ME, Marto JA, Sicinski P. Dev Cell. 2011 Oct 18;21(4):655-68.
David A. Guertin, PhD (Fellow ’03-’06), University of Massachusetts Medical School, Worcester
Sarcomas induced in discrete subsets of prospectively isolated skeletal muscle cells. Hettmer S, Liu J, Miller CM, Lindsay MC, Sparks CA, Guertin DA, Bronson RT, Langenau DM, Wagers AJ. Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):20002-7.
Yoh Isogai, PhD (Fellow ’08-’11), Harvard University, Cambridge
Molecular organization of vomeronasal chemoreception. Isogai Y, Si S, Pont-Lezica L, Tan T, Kapoor V, Murthy VN, Dulac C. Nature. 2011 Sep 21;478(7368):241-5.
Naoko Kobayashi, PhD (Damon Runyon Fellow ’91-’94), University of California, Los Angeles
Phase II Prospective Randomized Trial of a Low-Fat Diet with Fish Oil Supplementation in Men Undergoing Radical Prostatectomy. Aronson WJ, Kobayashi N, Barnard RJ, Henning S, Huang M, Jardack PM, Liu B, Gray A, Wan J, Konijeti R, Freedland SJ, Castor B, Heber D, Elashoff D, Said J, Cohen P, Galet C. Cancer Prev Res (Phila). 2011 Dec;4(12):2062-71.
Carla M. Koehler, PhD (Scholar ’00-’02, Fellow ’95-’98), University of California, Los Angeles
UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells. Zhang J, Khvorostov I, Hong JS, Oktay Y, Vergnes L, Nuebel E, Wahjudi PN, Setoguchi K, Wang G, Do A, Jung HJ, McCaffery JM, Kurland IJ, Reue K, Lee WN, Koehler CM, Teitell MA. EMBO J. 2011 Nov 15;30(24):4860-73.
Albert C. Koong, MD, PhD (Damon Runyon-Lilly Clinical Investigator ’02-’07), Stanford University School of Medicine, Stanford
A novel aldehyde dehydrogenase-3 activator leads to adult salivary stem cell enrichment in vivo. Banh A, Xiao N, Cao H, Chen CH, Kuo P, Krakow T, Bavan B, Khong B, Yao M, Ha C, Kaplan MJ, Sirjani D, Jensen K, Kong CS, Mochly-Rosen D, Koong AC, Le QT. Clin Cancer Res. 2011 Dec 1;17(23):7265-72.
David E. Lebwohl, MD (Fellow ’86-’87), Novartis, East Hanover
Everolimus in Postmenopausal Hormone-Receptor-Positive Advanced Breast Cancer. Baselga J, Campone M, Piccart M, Burris HA, Rugo HS, Sahmoud T, Noguchi S, Gnant M, Pritchard KI, Lebrun F, Beck JT, Ito Y, Yardley D, Deleu I, Perez A, Bachelot T, Vittori L, Xu Z, Mukhopadhyay P, Lebwohl D, Hortobagyi GN. N Engl J Med. 2011 Dec 7.
Mark A. Lemmon, PhD (Scholar ’97-’98, Fellow ’93-’96), University of Pennsylvania, Philadelphia
Differential inhibitor sensitivity of anaplastic lymphoma kinase variants found in neuroblastoma. Bresler SC, Wood AC, Haglund EA, Courtright J, Belcastro LT, Plegaria JS, Cole K, Toporovskaya Y, Zhao H, Carpenter EL, Christensen JG, Maris JM, Lemmon MA, Mossé YP. Sci Transl Med. 2011 Nov 9;3(108):108ra114.
Judith Lieberman, MD, PhD (Damon Runyon Fellow ’84-’86), Immune Disease Institute and Harvard Medical School, Boston
Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs. Tay Y, Kats L, Salmena L, Weiss D, Tan SM, Ala U, Karreth F, Poliseno L, Provero P, Di Cunto F, Lieberman J, Rigoutsos I, Pandolfi PP. Cell. 2011 Oct 14;147(2):344-57.
Jun O. Liu, PhD (Fellow ’91-’93), Johns Hopkins School of Medicine, Baltimore
Itraconazole inhibits angiogenesis and tumor growth in non-small cell lung cancer. Aftab BT, Dobromilskaya I, Liu JO, Rudin CM. Cancer Res. 2011 Nov 1;71(21):6764-72.
Itraconazole side chain analogues: structure-activity relationship studies for inhibition of endothelial cell proliferation, vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, and hedgehog signaling. Shi W, Nacev BA, Aftab BT, Head S, Rudin CM, Liu JO. J Med Chem. 2011 Oct 27;54(20):7363-74.
Henry T. Lynch (Grantee ’69-’70), Newcastle University, Newcastle upon Tyne, UK
Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial. Burn J, Gerdes AM, Macrae F, Mecklin JP, Moeslein G, Olschwang S, Eccles D, Evans DG, Maher ER, Bertario L, Bisgaard ML, Dunlop MG, Ho JW, Hodgson SV, Lindblom A, Lubinski J, Morrison PJ, Murday V, Ramesar R, Side L, Scott RJ, Thomas HJ, Vasen HF, Barker G, Crawford G, Elliott F, Movahedi M, Pylvanainen K, Wijnen JT, Fodde R, Lynch HT, Mathers JC, Bishop DT; on behalf of the CAPP2 Investigators. Lancet. 2011 Oct 27.
Matthew L. Meyerson, MD, PhD (Fellow ’95-’98), Dana-Farber Cancer Institute, Boston
Glioblastoma-Derived Epidermal Growth Factor Receptor Carboxyl-Terminal Deletion Mutants Are Transforming and Are Sensitive to EGFR-Directed Therapies. Cho J, Pastorino S, Zeng Q, Xu X, Johnson W, Vandenberg S, Verhaak R, Cherniack AD, Watanabe H, Dutt A, Kwon J, Chao YS, Onofrio RC, Chiang D, Yuza Y, Kesari S, Meyerson M. Cancer Res. 2011 Dec 15;71(24):7587-96.
Toru M. Nakamura, PhD (Fellow ’99-’02), University of Illinois, Chicago
Tel1(ATM) and Rad3(ATR) kinases promote Ccq1-Est1 interaction to maintain telomeres in fission yeast. Moser BA, Chang YT, Kosti J, Nakamura TM. Nat Struct Mol Biol. 2011 Nov 20;18(12):1408-13.
John M. Pagel, MD, PhD (Damon Runyon-Lilly Clinical Investigator ’05-’10), Fred Hutchinson Cancer Research Center, Seattle
Pretargeted radioimmunotherapy using genetically engineered antibody-streptavidin fusion proteins for treatment of non-hodgkin lymphoma. Park SI, Shenoi J, Frayo SM, Hamlin DK, Lin Y, Wilbur DS, Stayton PS, Orgun N, Hylarides M, Buchegger F, Kenoyer AL, Axtman A, Gopal AK, Green DJ, Pagel JM, Press OW. Clin Cancer Res. 2011 Dec 1;17(23):7373-82.
John E.J. Rasko, MD, PhD (Fellow ’96-’99), University of Sydney, Australia
Androgen Receptor and Nutrient Signaling Pathways Coordinate the Demand for Increased Amino Acid Transport during Prostate Cancer Progression. Wang Q, Bailey CG, Ng C, Tiffen J, Thoeng A, Minhas V, Lehman ML, Hendy SC, Buchanan G, Nelson CC, Rasko JE, Holst J. Cancer Res. 2011 Nov 28.
John L. Rinn, PhD (Damon Runyon-Rachleff Innovator ’09-’11, Damon Runyon Fellow ’05-’07)
and Cole Trapnell, PhD (Fellow ’11-’14), Harvard University, Cambridge
Targeted RNA sequencing reveals the deep complexity of the human transcriptome. Mercer TR, Gerhardt DJ, Dinger ME, Crawford J, Trapnell C, Jeddeloh JA, Mattick JS, Rinn JL. Nat Biotechnol. 2011 Nov 13. doi: 10.1038/nbt.2024.
Michael G. Roth, PhD (Fellow ’82-’84), UT Southwestern Medical Center, Dallas
Chemical inhibition of RNA viruses reveals REDD1 as a host defense factor. Mata MA, Satterly N, Versteeg GA, Frantz D, Wei S, Williams N, Schmolke M, Peña-Llopis S, Brugarolas J, Forst CV, White MA, García-Sastre A, Roth MG, Fontoura BM. Nat Chem Biol. 2011 Sep 11;7(10):712-9.
Julien Sage, PhD (Damon Runyon Scholar ’05-’07), Stanford University, Stanford
A crucial requirement for Hedgehog signaling in small cell lung cancer. Park KS, Martelotto LG, Peifer M, Sos ML, Karnezis AN, Mahjoub MR, Bernard K, Conklin JF, Szczepny A, Yuan J, Guo R, Ospina B, Falzon J, Bennett S, Brown TJ, Markovic A, Devereux WL, Ocasio CA, Chen JK, Stearns T, Thomas RK, Dorsch M, Buonamici S, Watkins DN, Peacock CD, Sage J. Nat Med. 2011 Oct 9;17(11):1504-8.
PDGF signalling controls age-dependent proliferation in pancreatic β-cells. Chen H, Gu X, Liu Y, Wang J, Wirt SE, Bottino R, Schorle H, Sage J, Kim SK. Nature. 2011 Oct 12;478(7369):349-55
Vered Stearns, MD (Damon Runyon-Lilly Clinical Investigator ’00-’05), Johns Hopkins University School of Medicine, Baltimore
Preclinical and clinical evaluation of intraductally administered agents in early breast cancer. Stearns V, Mori T, Jacobs LK, Khouri NF, Gabrielson E, Yoshida T, Kominsky SL, Huso DL, Jeter S, Powers P, Tarpinian K, Brown RJ, Lange JR, Rudek MA, Zhang Z, Tsangaris TN, Sukumar S. Sci Transl Med. 2011 Oct 26;3(106):106ra108.
Jean Y. Tang, MD, PhD (Clinical Investigator ’11-’14), Stanford University School of Medicine, Stanford
Sun protective behaviors and vitamin D levels in the US population: NHANES 2003-2006. Linos E, Keiser E, Kanzler M, Sainani KL, Lee W, Vittinghoff E, Chren MM, Tang JY. Cancer Causes Control. 2011 Nov 2.
Matthew G. Vander Heiden, MD, PhD (Damon Runyon-Rachleff Innovator ’11-’13, Fellow ’06-’08), MIT, Cambridge
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia. Metallo CM, Gameiro PA, Bell EL, Mattaini KR, Yang J, Hiller K, Jewell CM, Johnson ZR, Irvine DJ, Guarente L, Kelleher JK, Vander Heiden MG, Iliopoulos O, Stephanopoulos G. Nature. 2011 Nov 20.
Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Antioxidant Responses. Anastasiou D, Poulogiannis G, Asara JM, Boxer MB, Jiang JK, Shen M, Bellinger G, Sasaki AT, Locasale JW, Auld DS, Thomas CJ, Vander Heiden MG, Cantley LC. Science. 2011 Nov 3.
Maria del Mar Vivanco-Ruiz, PhD (Fellow ’92), CIC bioGUNE, Derio, Spain
and Lee Zou, PhD (Fellow ’00-’03), Massachusetts General Hospital, Charlestown
Homeobox B9 induces epithelial-to-mesenchymal transition-associated radioresistance by accelerating DNA damage responses. Chiba N, Comaills V, Shiotani B, Takahashi F, Shimada T, Tajima K, Winokur D, Hayashida T, Willers H, Brachtel E, Vivanco MD, Haber DA, Zou L, Maheswaran S. Proc Natl Acad Sci U S A. 2011 Sep 20.
Robert H. Vonderheide, MD, PhD (Damon Runyon-Lilly Clinical Investigator ’00-’05), University of Pennsylvania, Philadelphia
Karin U. Sorenmo, Erika Krick, Christina M. Coughlin, Beth Overley, Thomas P. Gregor, Robert H. Vonderheide, Nicola J. Mason. CD40-Activated B Cell Cancer Vaccine Improves Second Clinical Remission and Survival in Privately Owned Dogs with Non-Hodgkin’s Lymphoma. PLoS ONE, 2011; 6 (8): e24167
Xiaodong Wang, PhD (Fellow ’91-’94), University of Texas Southwestern Medical Center, Dallas
SMAC Mimetic (JP1201) Sensitizes Non-Small Cell Lung Cancers to Multiple Chemotherapy Agents in an IAP-Dependent but TNF-α-Independent Manner. Greer RM, Peyton M, Larsen JE, Girard L, Xie Y, Gazdar AF, Harran P, Wang L, Brekken RA, Wang X, Minna JD. Cancer Res. 2011 Dec 15;71(24):7640-8.
Catherine J. Wu, MD (Clinical Investigator ’07-’12), Dana-Farber Cancer Institute, Boston
and Matthew L. Meyerson, MD, PhD (Fellow ’95-’98), Dana-Farber Cancer Institute, Boston
SF3B1 and Other Novel Cancer Genes in Chronic Lymphocytic Leukemia. Wang L, Lawrence MS, Wan Y, Stojanov P, Sougnez C, Stevenson K, Werner L, Sivachenko A, Deluca DS, Zhang L, Zhang W, Vartanov AR, Fernandes SM, Goldstein NR, Folco EG, Cibulskis K, Tesar B, Sievers QL, Shefler E, Gabriel S, Hacohen N, Reed R, Meyerson M, Golub TR, Lander ES, Neuberg D, Brown JR, Getz G, Wu CJ. N Engl J Med. 2011 Dec 12.
Hongtao Yu, PhD (Scholar ’99-’00, Fellow ’95-’98), UT Southwestern Medical Center at Dallas
SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity. Kim HS, Vassilopoulos A, Wang RH, Lahusen T, Xiao Z, Xu X, Li C, Veenstra TD, Li B, Yu H, Ji J, Wang XW, Park SH, Cha YI, Gius D, Deng CX. Cancer Cell. 2011 Oct 18;20(4):487-99.
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