Damon Runyon Cancer Resources

October 7, 2009 > Nobel Prize in Chemistry 2009

Thomas A. Steitz, PhD (Former Damon Runyon Sponsor) of Yale University, New Haven was awarded the 2009 Nobel Prize in Chemistry “for studies of the structure and function of the ribosome.”  He shares the award with Venkatraman Ramakrishnan, PhD, of MRC Laboratory of Molecular Biology, Cambridge, United Kingdom, and Ada E. Yonath, PhD, of Weizmann Institute of Science, Rehovot, Israel.  Based upon the information in DNA, ribosomes make proteins; there are tens of thousands of proteins in the body, all providing different functions.  They build and control life at the chemical level.  Using X-ray crystallography, the awardees showed what the ribosome looks like and how it functions. 

As the target of many known antibiotics, the bacterial ribosome is a structure of major therapeutic importance. It is hoped that an understanding of precisely how antibiotics interact with the ribosome will allow the design of new antibiotics to tackle drug-resistant bacteria. Each of the awardees has imaged the molecular interactions between ribosomes and antibiotics, providing key data to help guide drug design of new antibiotics.

Click here for the press release.