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Early Career Scientists and High-Risk, High Reward Research - American Academy of Arts and Sciences
- Why We’re Losing the War on Cancer (And How To Win It)
Clifton Leaf - Fortune Magazine
October 9, 2008
Julien Sage, PhD (Damon Runyon Scholar '05-'07) and colleagues at Stanford University, Stanford, have discovered how the tumor suppressor family retinoblastoma (Rb) proteins affect stem cells. Removing Rb function resulted in overproliferation of a subclass of blood stem cells (myeloid cells); these actively-diving cells were also unable to repopulate the immune system in a mouse model of bone marrow transplantation. The researchers’ results indicate a critical role for Rb in suppressing tumors originating in stem cell populations, such as blood cancers. These findings were published in the journal Cell Stem Cell.
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