Damon Runyon Cancer Resources

January 1, 2009 >  Protein could be target for head and neck squamous cell carcinoma

Christine H. Chung, MD (Damon Runyon-Lilly Clinical Investigator '05-'10) of the Vanderbilt University School of Medicine, Nashville, and colleagues, identified a critical function of Protein Kinase Cα (PKCα) and microRNA miR-15a in regulating tumor cell growth in head and neck squamous cell carcinoma (SCCHN), a type of head and neck cancer.  The researchers demonstrated that agents that block PKCα decrease tumor growth in animal models, indicating that this protein may be a promising target for treatment of SCCHN.  These findings were published in the journal Cancer Research.

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