In this issue:  Upcoming Deadlines and Events  |  Awards and Honors  |  Publications

Science Update: April - June 2011

Dear Damon Runyon Scientists,

We are pleased to announce the newest awardees of the Clinical Investigator and Fellowship Awards: 27 awards were granted, totaling over $6.25 million. We also recently launched a new initiative, Accelerating Cancer Cures, a new model for collaboration that will raise $25 million over the next five years to fund 50 of the most promising young clinical investigators in cancer research.

Please see below for the latest update on exciting news and findings from your fellow Damon Runyon scientists – current and former. These are just the publications and awards that we are aware of, so we apologize if we have not included your work. Lay summaries of some of this work are posted on the News page of our website, along with additional news about our Scientific Committee and Board members.

Thanks again to those of you who have sent us updates on your recent progress. It is always a pleasure to learn about the continuing success of our current scientists and alumni and to share your findings with the entire Damon Runyon community. Please continue to stay in touch and enjoy the summer!

Best regards,

Yung

Yung S. Lie, PhD
Scientific Director
Damon Runyon Cancer Research Foundation
One Exchange Plaza
55 Broadway, Suite 302
New York, NY 10006
212.455.0521
212.455.0529 FAX
yung.lie@damonrunyon.org

UPCOMING DEADLINES and EVENTS

Fellowship Award Application Deadline

> August 15, 2011
Details available on our website.

Runyon 5K at Yankee Stadium

> August 7, 2011
Join us for our 3rd annual 5K run for cancer research! Register now—fewer than 100 spots remain!
Details available on our website.

AWARDS and HONORS

Election to the National Academy of Sciences:
Alexander D. Johnson, PhD (Fellow ‘81-‘83 and Former Sponsor), University of California, San Francisco

Luis F. Parada, PhD (Fellow ‘85-‘86 and Fellowship Award Committee ‘99-‘03), University of Texas Southwestern Medical Center, Dallas

2011 AACR-GlaxoSmithKline Clinical Cancer Research Scholar Award:
Akinyemi I. Ojesina, MBBS, PhD (Rebecca Ridley Kry Fellow ‘08-‘11), Dana-Farber Cancer Institute, Cambridge

2011 Junior Career Recognition Award from the American Society for Cell Biology:
Melissa M. Rolls, PhD (Fellow ‘03-‘05), Penn State University, University Park

PUBLICATIONS

Laura D. Attardi, PhD (Scholar ‘02-‘04), Stanford University School of Medicine, Stanford
Distinct p53 Transcriptional Programs Dictate Acute DNA-Damage Responses and Tumor Suppression. Brady CA, Jiang D, Mello SS, Johnson TM, Jarvis LA, Kozak MM, Broz DK, Basak S, Park EJ, McLaughlin ME, Karnezis AN, Attardi LD. Cell. 2011 May 13;145(4):571-83.

Sean C. Bendall, PhD (Fellow ‘09-‘12), Stanford University, Stanford
Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum. Bendall SC, Simonds EF, Qiu P, Amir el-AD, Krutzik PO, Finck R, Bruggner RV, Melamed R, Trejo A, Ornatsky OI, Balderas RS, Plevritis SK, Sachs K, Pe’er D, Tanner SD, Nolan GP. Science. 2011 May 6;332(6030):687-96.

Renier J. Brentjens, MD, PhD (Damon Runyon-Lilly Clinical Investigator ‘06-‘11), Memorial Sloan-Kettering Cancer Center, New York
In vivo inhibition of human CD19-targeted effector T cells by natural T regulatory cells in a xenotransplant murine model of B cell malignancy. Lee JC, Hayman E, Pegram HJ, Santos E, Heller G, Sadelain M, Brentjens R. Cancer Res. 2011 Apr 15;71(8):2871-81.

Ronald J. Buckanovich, MD, PhD (Clinical Investigator ‘08-‘11), University of Michigan, Ann Arbor
Aldehyde Dehydrogenase in Combination with CD133 Defines Angiogenic Ovarian Cancer Stem Cells That Portend Poor Patient Survival. Silva IA, Bai S, McLean K, Yang K, Griffith KA, Dafydd T, Ginestier C, Johnston C, Kueck A, Reynolds K, Wicha MS, Buckanovich RJ. Cancer Res 2011;71 3991-4001

Human ovarian carcinoma-associated mesenchymal stem cells regulate cancer stem cells and tumorigenesis via altered BMP production. McLean K, Gong Y, Choi Y, Deng N, Yang K, Bai S, Cabrera L, Keller E, McCauley L, Cho KR, Buckanovich RJ. J Clin Invest. 2011 Jul 1.

Andrew T. Chan, MD, MPH (Damon Runyon Clinical Investigator ‘08-‘11), Massachusetts General Hospital, Boston
Association of CTNNB1 (beta-catenin) alterations, body mass index, and physical activity with survival in patients with colorectal cancer. Morikawa T, Kuchiba A, Yamauchi M, Meyerhardt JA, Shima K, Nosho K, Chan AT, Giovannucci E, Fuchs CS, Ogino S. JAMA. 2011 Apr 27;305(16):1685-94.

Statin use and colorectal cancer risk according to molecular subtypes in two large prospective cohort studies. Lee JE, Baba Y, Ng K, Giovannucci E, Fuchs C, Ogino S, Chan AT. Cancer Prev Res (Phila). 2011 Jun 16.

Howard Y. Chang, MD, PhD (Kenneth G. and Elaine A. Langone Scholar ‘06-‘08), Stanford University, Stanford
Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters. Hung T, Wang Y, Lin MF, Koegel AK, Kotake Y, Grant GD, Horlings HM, Shah N, Umbricht C, Wang P, Wang Y, Kong B, Langerød A, Børresen-Dale AL, Kim SK, van de Vijver M, Sukumar S, Whitfield ML, Kellis M, Xiong Y, Wong DJ, Chang HY. Nat Genet. 2011 Jun 5;43(7):621-9.

Ondine B. Cleaver, PhD (Fellow ‘99-‘02), University of Texas Southwestern Medical Center, Dallas
Blood vessel tubulogenesis requires Rasip1 regulation of GTPase signaling. Xu K, Sacharidou A, Fu S, Chong DC, Skaug B, Chen ZJ, Davis GE, Cleaver O. Dev Cell. 2011 Apr 19;20(4):526-39.

Marc I. Damelin, PhD (Fellow ‘03-‘06), Pfizer Inc., Pearl River
Delineation of a cellular hierarchy in lung cancer reveals an oncofetal antigen expressed on tumor-initiating cells. Damelin M, Geles KG, Follettie MT, Yuan P, Baxter M, Golas J, Dijoseph JF, Karnoub M, Huang S, Diesl V, Behrens C, Choe SE, Rios C, Gruzas J, Sridharan L, Dougher M, Kunz A, Hamann PR, Evans D, Armellino D, Khandke K, Marquette K, Tchistiakova L, Boghaert ER, Abraham RT, Wistuba II, Zhou BB. Cancer Res. 2011 Jun 15;71(12):4236-46.

Joshua E. Elias, PhD (Damon Runyon-Rachleff Innovator ‘11-‘13) Stanford University, Stanford
A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers. Jirawatnotai S, Hu Y, Michowski W, Elias JE, Becks L, Bienvenu F, Zagozdzon A, Goswami T, Wang YE, Clark AB, Kunkel TA, van Harn T, Xia B, Correll M, Quackenbush J, Livingston DM, Gygi SP, Sicinski P. Nature. 2011 Jun 8;474(7350):230-4.

Michael J. Emanuele, PhD (Philip O’Bryan Montgomery, Jr., MD, Fellow ‘08-‘11), Brigham and Women’s Hospital, Boston
Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyclosome substrate. Emanuele MJ, Ciccia A, Elia AE, Elledge SJ. Proc Natl Acad Sci U S A. 2011 May 31.

Dean W. Felsher, MD, PhD (Damon Runyon-Lilly Clinical Investigator ‘03-‘08) and
Julien Sage, PhD (Damon Runyon Scholar ‘05-‘07), Stanford University, Stanford
Functional interactions between retinoblastoma and c-MYC in a mouse model of hepatocellular carcinoma. Saddic LA, Wirt S, Vogel H, Felsher DW, Sage J. PLoS One. 2011 May 6;6(5):e19758.

Nathanael S. Gray, PhD (Damon Runyon-Rachleff Innovator ‘08-‘10), Dana-Farber Cancer Institute, Boston
The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Hsu PP, Kang SA, Rameseder J, Zhang Y, Ottina KA, Lim D, Peterson TR, Choi Y, Gray NS, Yaffe MB, Marto JA, Sabatini DM. Science. 2011 Jun 10;332(6035):1317-22.

Inhibitor-Sensitive FGFR1 Amplification in Human Non-Small Cell Lung Cancer. Dutt A, Ramos AH, Hammerman PS, Mermel C, Cho J, Sharifnia T, Chande A, Tanaka KE, Stransky N, Greulich H, Gray NS, Meyerson M. PLoS One. 2011;6(6):e20351. Epub 2011 Jun 7.

William C. Hahn, MD, PhD (Fellow ‘98-‘99) and
Serena J. Silver, PhD (Fellow ‘05-‘06), Dana-Farber Cancer Institute, Boston
The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24- stem cell-like breast cancer cells in human tumors. Marotta LL, Almendro V, Marusyk A, Shipitsin M, Schemme J, Walker SR, Bloushtain-Qimron N, Kim JJ, Choudhury SA, Maruyama R, Wu Z, Gönen M, Mulvey LA, Bessarabova MO, Huh SJ, Silver SJ, Kim SY, Park SY, Lee HE, Anderson KS, Richardson AL, Nikolskaya T, Nikolsky Y, Liu XS, Root DE, Hahn WC, Frank DA, Polyak K. J Clin Invest. 2011 Jul 1;121(7).

Daniel A. Heller, PhD (Fellow ‘10-‘13), MIT, Cambridge
Peptide secondary structure modulates single-walled carbon nanotube fluorescence as a chaperone sensor for nitroaromatics. Heller DA, Pratt GW, Zhang J, Nair N, Hansborough AJ, Boghossian AA, Reuel NF, Barone PW, Strano MS. Proc Natl Acad Sci U S A. 2011 May 9.

N. Lynn Henry, MD, PhD (Damon Runyon-Lilly Clinical Investigator ‘10-‘13), University of Michigan, Ann Arbor
Pilot study of duloxetine for treatment of aromatase inhibitor-associated musculoskeletal symptoms. Henry NL, Banerjee M, Wicha M, Van Poznak C, Smerage JB, Schott AF, Griggs JJ, Hayes DF. Cancer. 2011 Jun 20.

Valerie Horsley, PhD (Damon Runyon Fellow ‘04-‘07), Yale University, New Haven and
Elaine V. Fuchs, PhD (Fellow ‘77, Board Member), The Rockefeller University, New York
Ferreting out stem cells from their niches. Fuchs E, Horsley V. Nat Cell Biol. 2011 May;13(5):513-8.

John Karanicolas, PhD (Fellow ‘04-‘07), University of Kansas, Lawrence
A de novo protein binding pair by computational design and directed evolution. Karanicolas J, Corn JE, Chen I, Joachimiak LA, Dym O, Peck SH, Albeck S, Unger T, Hu W, Liu G, Delbecq S, T Montelione G, P Spiegel C, Liu DR, Baker D. Mol Cell. 2011 Apr 22;42(2):250-60.

Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation. Sievers SA, Karanicolas J, Chang HW, Zhao A, Jiang L, Zirafi O, Stevens JT, Münch J, Baker D, Eisenberg D. Nature. 2011 Jun 15;475(7354):96-100.

Vassiliki Karantza, MD, PhD (Clinical Investigator ‘08-‘13), University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway
Rationally designed treatment for solid tumors with MAPK pathway activation: a Phase I study of paclitaxel and bortezomib using an adaptive dose-finding approach. Mehnert JM, Tan AR, Moss RA, Poplin EA, Stein M, Sovak MA, Levinson K, Lin H, Kane M, Gounder M, Lin Y, Shih WJ, White EP, Rubin EH, Karantza V. Mol Cancer Ther. 2011 Jun 16.

William Y. Kim, MD (Merck Clinical Investigator ‘09-‘12), University of North Carolina School of Medicine, Chapel Hill
Loss of JAK2 regulation via a heterodimeric VHL-SOCS1 E3 ubiquitin ligase underlies Chuvash polycythemia. Russell RC, Sufan RI, Zhou B, Heir P, Bunda S, Sybingco SS, Greer SN, Roche O, Heathcote SA, Chow VW, Boba LM, Richmond TD, Hickey MM, Barber DL, Cheresh DA, Simon MC, Irwin MS, Kim WY, Ohh M. Nat Med. 2011 Jun 19;17(7):845-53.

Albert C. Koong, MD, PhD (Damon Runyon-Lilly Clinical Investigator ‘02-‘07), Stanford University, Stanford
Tumor galectin-1 mediates lung cancer growth and metastasis through regulation of T-cell apoptosis. Banh A, Zhang J, Cao H, Bouley DM, Kwok S, Kong C, Giaccia AJ, Koong AC, Le QT. Cancer Res. 2011 May 5.

Sridhar Mani, MD (Damon Runyon-Lilly Clinical Investigator ‘02-‘07), Albert Einstein Medical School, Bronx
In vivo and in vitro characterization of a first-in-class novel azole analog that targets PXR activation. Venkatesh M, Wang H, Cayer J, Leroux M, Salvail D, Das B, Mani S. Mol Pharmacol. 2011 Apr 4.

Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice. Wang H, Venkatesh M, Li H, Goetz R, Mukherjee S, Biswas A, Zhu L, Kaubisch A, Wang L, Pullman J, Whitney K, Kuro-O M, Roig AI, Shay JW, Mohammadi M, Mani S. J Clin Invest. 2011 Jul 11. pii: 41514. doi: 10.1172/JCI41514.

Sarkis K. Mazmanian, PhD (Damon Runyon-Rachleff Innovator ‘08-‘11), California Institute of Technology, Pasadena
The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota. Round JL, Lee SM, Li J, Tran G, Jabri B, Chatila TA, Mazmanian SK. Science. 2011 May 20;332(6032):974-7.

Elahe A. Mostaghel, MD, PhD (Damon Runyon-Genentech Clinical Investigator ‘08-‘11), Fred Hutchinson Cancer Research Center, Seattle
SLCO2B1 and SLCO1B3 May Determine Time to Progression for Patients Receiving Androgen Deprivation Therapy for Prostate Cancer. Yang M, Xie W, Mostaghel E, Nakabayashi M, Werner L, Sun T, Pomerantz M, Freedman M, Ross R, Regan M, Sharifi N, Figg WD, Balk S, Brown M, Taplin ME, Oh WK, Lee GS, Kantoff PW. J Clin Oncol. 2011 Jun 20;29(18):2565-73.

Akinyemi I. Ojesina, MBBS, PhD (Rebecca Ridley Kry Fellow ‘08-‘11), Dana-Farber Cancer Institute, Cambridge
PathSeq: software to identify or discover microbes by deep sequencing of human tissue. Kostic AD, Ojesina AI, Pedamallu CS, Jung J, Verhaak RG, Getz G, Meyerson M. Nat Biotechnol. 2011 May;29(5):393-6.

John M. Pagel, MD, PhD (Damon Runyon-Lilly Clinical Investigator ‘05-‘10), Fred Hutchinson Cancer Research Center, Seattle
Anti-CD45 pretargeted radioimmunotherapy using bismuth-213: high rates of complete remission and long-term survival in a mouse myeloid leukemia xenograft model. Pagel JM, Kenoyer AL, Bäck T, Hamlin DK, Wilbur DS, Fisher DR, Park SI, Frayo S, Axtman A, Orgun N, Orozco J, Shenoi J, Lin Y, Gopal AK, Green DJ, Appelbaum FR, Press OW. Blood. 2011 May 25.

Amanda G. Paulovich, MD, PhD (Fellow ‘02-‘03), and
Peter S. Nelson, MD (Scholar ‘02-‘04, Clinical Investigator Mentor), Fred Hutchinson Cancer Research Center, Seattle
A targeted proteomics-based pipeline for verification of biomarkers in plasma. Whiteaker JR, Lin C, Kennedy J, Hou L, Trute M, Sokal I, Yan P, Schoenherr RM, Zhao L, Voytovich UJ, Kelly-Spratt KS, Krasnoselsky A, Gafken PR, Hogan JM, Jones LA, Wang P, Amon L, Chodosh LA, Nelson PS, McIntosh MW, Kemp CJ, Paulovich AG. Nat Biotechnol. 2011 Jun 19;29(7):625-34.

Sarah B. Pierce, PhD (Fellow ‘98-‘01), University of Washington, Seattle
Mutations in Mitochondrial Histidyl tRNA Synthetase HARS2 Cause Ovarian Dysgenesis and Sensorineural Hearing Loss of Perrault Syndrome. Pierce, S. B., Chisholm, K. M., Lynch, E. D., Lee, M. K., Walsh, T., Opitz, J. M., Li, W., Klevit, R, E., King, M. C. Proc. Natl. Acad. Sci. U. S. A. 2011, 108, 6543-6548.

John L. Rinn, PhD (Damon Runyon-Rachleff Innovator ‘09-‘11, Fellow ‘05-‘07, Fellowship Sponsor), and
Pardis C. Sabeti, MD, DPhil (Damon Runyon Fellow ‘04-‘06), Harvard University, Cambridge
A global transcriptional analysis of Plasmodium falciparum malaria reveals a novel family of telomere-associated lncRNAs. Kate Broadbent, Daniel Park, Ashley R Wolf, Daria Van Tyne, Jennifer S Sims, Ulf Ribacke, Sarah Volkman, Manoj Duraisingh, Dyann Wirth, Pardis C Sabeti and John L Rinn. Genome Biology 2011, 12:R56 doi:10.1186/gb-2011-12-6-r56

Joel H. Rubenstein, MD (Damon Runyon-Lilly Clinical Investigator ‘07-‘10), University of Michigan, Ann Arbor
Helicobacter pylori DNA decreases pro-inflammatory cytokine production by dendritic cells and attenuates dextran sodium sulphate-induced colitis. Luther J, Owyang SY, Takeuchi T, Cole TS, Zhang M, Liu M, Erb-Downward J, Rubenstein JH, Chen CC, Pierzchala AV, Paul JA, Kao JY. Gut. 2011 Apr 6.

Katharina Schlacher, PhD (Fellow ‘07-‘10), Memorial Sloan-Kettering Cancer Center, New York
Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11. Schlacher K, Christ N, Siaud N, Egashira A, Wu H, Jasin M. Cell. 2011 May 13;145(4):529-42.

John A. Tainer, PhD (Fellow‘82-‘84), The Scripps Research Institute, La Jolla
Human Flap Endonuclease Structures, DNA Double-Base Flipping, and a Unified Understanding of the FEN1 Superfamily. Tsutakawa SE, Classen S, Chapados BR, Arvai AS, Finger LD, Guenther G, Tomlinson CG, Thompson P, Sarker AH, Shen B, Cooper PK, Grasby JA, Tainer JA. Cell. 2011 Apr 15;145(2):198-211.

Jean Y. Tang, MD, PhD (Clinical Investigator ‘11-‘14), Stanford University, Stanford
Calcium Plus Vitamin D Supplementation and the Risk of Nonmelanoma and Melanoma Skin Cancer: Post Hoc Analyses of the Women’s Health Initiative Randomized Controlled Trial. Tang JY, Fu T, Leblanc E, Manson JE, Feldman D, Linos E, Vitolins MZ, Zeitouni NC, Larson J, Stefanick ML. J Clin Oncol. 2011 Jun 27.

W. Andy Tao, PhD (Fellow ‘02-‘05), Purdue University, West Lafayette
Identification of Drug Targets In Vitro and in Living Cells by Soluble-Nanopolymer-Based Proteomics. Hu L, Iliuk A, Galan J, Hans M, Tao WA. Angew Chem Int Ed Engl. 2011 Mar 31. doi: 10.1002/anie.201006459.

John M. Timmerman, MD (Damon Runyon-Lilly Clinical Investigator ‘05-‘10), University of California, Los Angeles
Programmed death ligand 1 (PD-L1) is expressed by non-Hodgkin lymphomas and inhibits the activity of tumor-associated T cells. Andorsky DJ, Yamada R, Said JW, Pinkus GS, Betting DJ, Timmerman JM. Clin Cancer Res. 2011 May 3.

Benjamin P. Tu, PhD (Damon Runyon-Rachleff Innovator ‘11-‘13), University of Texas Southwestern Medical Center, Dallas
Acetyl-CoA Induces Cell Growth and Proliferation by Promoting the Acetylation of Histones at Growth Genes. Cai L, Sutter BM, Li B, Tu BP. Mol Cell. 2011 May 20;42(4):426-37.

Monte Winslow, PhD (Damon Runyon Fellow ‘06-‘09), MIT, Cambridge
Suppression of lung adenocarcinoma progression by Nkx2-1. Winslow MM, Dayton TL, Verhaak RG, Kim-Kiselak C, Snyder EL, Feldser DM, Hubbard DD, Dupage MJ, Whittaker CA, Hoersch S, Yoon S, Crowley D, Bronson RT, Chiang DY, Meyerson M, Jacks T. Nature. 2011 Apr 6

Hong Wu, MD, PhD (Damon Runyon Fellow ‘92-‘95, Former Fellowship Sponsor), University of California Jonsson Comprehensive Cancer Center, Los Angeles
Dual Targeting of Phosphoinositide 3-Kinase and Mammalian Target of Rapamycin Using NVP-BEZ235 as a Novel Therapeutic Approach in Human Ovarian Carcinoma. Santiskulvong C, Konecny GE, Fekete M, Chen KY, Karam A, Mulholland D, Eng C, Wu H, Song M, Dorigo O. Clin Cancer Res. 2011 Apr 15;17(8):2373-84.

Cell Autonomous Role of PTEN in Regulating Castration-Resistant Prostate Cancer Growth. Mulholland DJ, Tran LM, Li Y, Cai H, Morim A, Wang S, Plaisier S, Garraway IP, Huang J, Graeber TG, Wu H. Cancer Cell. 2011 Jun 14;19(6):792-804.

Yun Wu, PhD (Fellow ‘07-‘09), Princeton University, Princeton
Tuzon CT, Wu Y, Chan A, Zakian VA, 2011 The Saccharomyces cerevisiae Telomerase Subunit Est3 Binds Telomeres in a Cell Cycle– and Est1–Dependent Manner and Interacts Directly with Est1 In Vitro. PLoS Genet 7(5): e1002060. doi:10.1371/journal.pgen.1002060

Hai Yan, MD, PhD (Damon Runyon Scholar ‘05-‘07), Duke University, Durham
Altered Telomeres in Tumors with ATRX and DAXX Mutations. Heaphy CM, de Wilde RF, Jiao Y, Klein AP, Edil BH, Shi C, Bettegowda C, Rodriguez FJ, Eberhart CG, Hebbar S, Offerhaus JA, McLendon R, Rasheed BA, He Y, Yan H, Bigner DD, Oba-Shinjo SM, Marie SK, Riggins GJ, Kinzler KW, Vogelstein B, Hruban RH, Maitra A, Papadopoulos N, Meeker AK. Science. 2011 Jun 30.

Yi-Tao Yu, PhD (Fellow ‘95-‘98), University of Rochester Medical Center, Rochester
Converting nonsense codons into sense codons by targeted pseudouridylation. Karijolich J, Yu YT. Nature. 2011 Jun 15;474(7351):395-8.

Gerard P. Zambetti, PhD (Fellow ‘90-‘93), Washington University, St. Louis
Identification of a novel TP53 cancer susceptibility mutation through whole-genome sequencing of a patient with therapy-related AML. Link DC, Schuettpelz LG, Shen D, Wang J, Walter MJ, Kulkarni S, Payton JE, Ivanovich J, Goodfellow PJ, Le Beau M, Koboldt DC, Dooling DJ, Fulton RS, Bender RH, Fulton LL, Delehaunty KD, Fronick CC, Appelbaum EL, Schmidt H, Abbott R, O’Laughlin M, Chen K, McLellan MD, Varghese N, Nagarajan R, Heath S, Graubert TA, Ding L, Ley TJ, Zambetti GP, Wilson RK, Mardis ER. JAMA. 2011 Apr 20;305(15):1568-76.

> Visit the New Discoveries and Honors page for more.