In this issue:  Upcoming Deadlines and Events  |  Awards and Honors  |  Publications  

Science Update: January - March 2011

Dear Damon Runyon Scientists,

We started off the year by announcing the newest awardees of the Fellowship and Innovation Awards: 16 awards were granted, totaling nearly $4 million. Our Scientific Committees will be meeting again in April and May to select new Clinical Investigators and Fellows.

Please see below for the latest update on exciting news and findings from your fellow Damon Runyon scientists – current and former. These are just the publications and awards that we are aware of, so we apologize if we have not included your work. Lay summaries of some of this work are posted on the News page of our website, along with additional news about our Scientific Committee and Board members.

Thanks again to those of you who have sent us updates on your recent progress. It is always a pleasure to learn about the continuing success of our current scientists and alumni and to share your findings with the entire Damon Runyon community. Please continue to stay in touch and enjoy the spring!

Best regards,

Yung

Yung S. Lie, PhD
Scientific Director
Damon Runyon Cancer Research Foundation
One Exchange Plaza
55 Broadway, Suite 302
New York, NY 10006
212.455.0521
212.455.0529 FAX
yung.lie@damonrunyon.org

UPCOMING DEADLINES and EVENTS

> June 1, 2011
Damon Runyon-Rachleff Innovation Award Application Deadline
Details available on our website.

This award is designed to provide support for the next generation of exceptionally creative thinkers with “high-risk/high-reward” ideas that have the potential to significantly impact our understanding of and/or approaches to the prevention, diagnosis or treatment of cancer.

> July 15, 2011
Dale F. Frey Award for Breakthrough Scientists Application Deadline
Details available on our website.

At the end of the Fellowship, there are often a select few Damon Runyon Fellows who have greatly exceeded the Foundation’s highest expectations. To catapult their research careers—and their impact on cancer—the Foundation will make an additional investment in these exceptional individuals by selecting them as the recipients of the Dale F. Frey Award for Breakthrough Scientists.

> August 7, 2011
Runyon 5K at Yankee Stadium
Details available on our website.

Save the date to join us for our 3rd annual 5K run! Registration opens at 12 noon on Tuesday, May 3, 2011. Visit www.damonrunyon.org/yankeestadium for more information.

AWARDS and HONORS

2011 Albany Medical Center Prize in Medicine and Biomedical Research:
Elaine V. Fuchs, PhD (Damon Runyon Board Member, Fellow ‘77-‘79), The Rockefeller University, New York

James A. Thomson, VMD, PhD (Current Fellowship Sponsor), Morgridge Institute for Research at the University of Wisconsin, Madison

2011 Canada Gairdner International Award:
Adrian P. Bird, PhD (Damon Runyon Fellow ‘71-‘73), University of Edinburgh, Edinburgh

2010 Louisa Gross Horwitz Prize:
Bruce W. Stillman, PhD (Damon Runyon Fellow ‘79-‘81), Cold Spring Harbor Laboratory, Cold Spring Harbor

Appointment to the National Cancer Advisory Board:
William R. Sellers, MD (Damon Runyon Board Member, Damon Runyon-Lilly Clinical Investigator ‘01-‘05), Novartis Institutes for BioMedical Research, Cambridge

2011 AACR Awards:
Nathanael S. Gray, PhD (Damon Runyon-Rachleff Innovator ‘08-‘10), Dana-Farber Cancer Institute, Boston: 31st Annual AACR Award for Outstanding Achievement in Cancer Research

Philip C. Hanawalt, PhD (Former Fellowship Sponsor), Stanford University, Stanford: Fifth Annual AACR Princess Takamatsu Memorial Lectureship

Guillermina (Gigi) Lozano, PhD (Former Fellowship Award Committee Member), The University of Texas MD Anderson Cancer Center, Houston: Sixth Annual AACR-Minorities in Cancer Research Jane Cooke Wright Lectureship

Carol L. Prives, PhD (Damon Runyon Fellow ’68), Columbia University, New York: 14th Annual AACR-Women in Cancer Research Charlotte Friend Memorial Lectureship

Gregory L. Verdine, PhD (Former Fellowship Award Committee Member), Harvard University, Cambridge: 5th Annual AACR Award for Outstanding Achievement in Chemistry in Cancer Research

PUBLICATIONS

John B. Biggins, PhD (Damon Runyon Fellow ‘05-‘07), The Rockefeller University, New York
Acyldepsipeptide HDAC Inhibitor Production Induced in Burkholderia thailandensis. Biggins JB, Gleber CD, Brady SF. Org Lett. 2011 Mar 18;13(6):1536-9.

Metabolites from the Induced Expression of Cryptic Single Operons Found in the Genome of Burkholderia pseudomallei. Biggins JB, Liu X, Feng Z, Brady SF. J Am Chem Soc. 2011 Jan 19.

James E. Bradner, MD (Damon Runyon-Rachleff Innovator ‘11-‘13), Dana-Farber Cancer Institute, Boston
Differentiation of NUT Midline Carcinoma by Epigenomic Reprogramming. Schwartz BE, Hofer MD, Lemieux ME, Bauer DE, Cameron MJ, West NH, Agoston ES, Reynoird N, Khochbin S, Ince TA, Christie A, Janeway KA, Vargas SO, Perez-Atayde AR, Aster JC, Sallan SE, Kung AL, Bradner JE, French CA. Cancer Res. 2011 Apr 1;71(7):2686-96.

Joseph A. Califano, MD (Damon Runyon-Lilly Clinical Investigator ‘01-‘06), Johns Hopkins Medical Institutions, Baltimore
Chronic CSE Treatment Induces the Growth of Normal Oral Keratinocytes via PDK2 Upregulation, Increased Glycolysis and HIF1α Stabilization. Sun W, Chang SS, Fu Y, Liu Y, Califano JA. PLoS One. 2011 Jan 19;6(1):e16207.

Tobias J.E. Carling, MD, PhD (Damon Runyon-Doris Duke Clinical Investigator ‘10-‘13), Yale University School of Medicine, New Haven
K+ channel mutations in adrenal aldosterone-producing adenomas and hereditary hypertension. Choi M, Scholl UI, Yue P, Björklund P, Zhao B, Nelson-Williams C, Ji W, Cho Y, Patel A, Men CJ, Lolis E, Wisgerhof MV, Geller DS, Mane S, Hellman P, Westin G, Akerström G, Wang W, Carling T, Lifton RP. Science. 2011 Feb 11;331(6018):768-72.

Craig J. Ceol, PhD (Damon Runyon Fellow ‘05-‘07), University of Massachussetts, Worcester
The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset. Ceol CJ, Houvras Y, Jane-Valbuena J, Bilodeau S, Orlando DA, Battisti V, Fritsch L, Lin WM, Hollmann TJ, Ferré F, Bourque C, Burke CJ, Turner L, Uong A, Johnson LA, Beroukhim R, Mermel CH, Loda M, Ait-Si-Ali S, Garraway LA, Young RA, Zon LI. Nature. 2011 Mar 24;471(7339):513-7.

Andrew T. Chan, MD, MPH (Damon Runyon Clinical Investigator ‘08-‘11), Massachusetts General Hospital, Boston
Inflammatory markers are associated with risk of colorectal cancer and chemopreventive response to anti-inflammatory drugs. Chan AT, Ogino S, Giovannucci EL, Fuchs CS. Gastroenterology. 2011 Mar;140(3):799-808.

Use of Aspirin or Nonsteroidal Anti-Inflammatory Drugs Increases Risk for Diverticulitis and Diverticular Bleeding. Strate LL, Liu YL, Huang ES, Giovannucci EL, Chan AT. Gastroenterology. 2011 Feb 12.

A prospective study of aspirin use and the risk of gastrointestinal bleeding in men. Huang ES, Strate LL, Ho WW, Lee SS, Chan AT. PLoS One. 2010 Dec 29;5(12):e15721.

Howard Y. Chang, MD, PhD (Damon Runyon Scholar ‘06-‘08, Former Fellowship Sponsor ‘05-‘07), Stanford University, Stanford
A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression. Wang KC, Yang YW, Liu B, Sanyal A, Corces-Zimmerman R, Chen Y, Lajoie BR, Protacio A, Flynn RA, Gupta RA, Wysocka J, Lei M, Dekker J, Helms JA, Chang HY. Nature. 2011 Mar 20.

Jayanta Chaudhuri, PhD (Damon Runyon Scholar ‘06-‘08, Damon Runyon Fellow ‘97-‘00), Memorial Sloan-Kettering Cancer Center, New York
The splicing regulator PTBP2 interacts with the cytidine deaminase AID and promotes binding of AID to switch-region DNA. Nowak U, Matthews AJ, Zheng S, Chaudhuri J. Nat Immunol. 2010 Dec 26.

Chonghui Cheng, PhD (Damon Runyon Fellow ‘01-‘03), Northwestern University, Chicago, and
Jing Yang, PhD (Damon Runyon Fellow ‘00-‘03), University of California, San Diego
CD44 splice isoform switching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progression. Brown RL, Reinke LM, Damerow MS, Perez D, Chodosh LA, Yang J, Cheng C. J Clin Invest. 2011 Feb 14. pii: 44540.

Christine H. Chung, MD (Damon Runyon-Lilly Clinical Investigator ‘05-‘10), The Johns Hopkins University, Baltimore
Epithelial tissues have varying degrees of susceptibility to kras-initiated tumorigenesis in a mouse model. Ray KC, Bell KM, Yan J, Gu G, Chung CH, Washington MK, Means AL. PLoS One. 2011 Feb 2;6(2):e16786.

Glioma-Associated Oncogene Family Zinc Finger 1 Expression and Metastasis in Patients With Head and Neck Squamous Cell Carcinoma Treated With Radiation Therapy (RTOG 9003). Chung CH, Dignam JJ, Elizabeth Hammond M, Klimowicz AC, Petrillo SK, Magliocco A, Jordan R, Trotti A, Spencer S, Cooper JS, Le QT, Ang KK. J Clin Oncol. 2011 Apr 1;29(10):1326-34.

L. Stirling Churchman, PhD (Dale Frey Scientist ‘11, Damon Runyon-Merck Fellow ‘08-‘11), University of California, San Francisco
Nascent transcript sequencing visualizes transcription at nucleotide resolution. Churchman LS, Weissman JS. Nature. 2011 Jan 20;469(7330):368-73.

Rachael A. Clark, MD, PhD (Damon Runyon Clinical Investigator ‘08-‘11), Brigham and Women’s Hospital, Boston
Resident Memory T Cells (T(RM)) Are Abundant in Human Lung: Diversity, Function, and Antigen Specificity. Purwar R, Campbell J, Murphy G, Richards WG, Clark RA, Kupper TS. PLoS One. 2011 Jan 26;6(1):e16245.

Thomas Curran, PhD, FRS (Former Fellowship Award Committee, Damon Runyon Fellow ‘82-‘84), University of Pennsylvania, Philadelphia, and
Daniela S. Gerhard, PhD (Damon Runyon Fellow ‘83-‘85), NCI, Bethesda, and
Kenneth W. Kinzler, PhD (Innovation Award Committee Member), The Johns Hopkins University, Baltimore, and
Peter C. Phillips, MD (Damon Runyon Fellow ‘84-‘86), The Children’s Hospital of Philadelphia, and
Hai Yan, MD, PhD (Damon Runyon Scholar ‘05-‘07), Duke University, Durham
The Genetic Landscape of the Childhood Cancer Medulloblastoma. Parsons DW, Li M, Zhang X, Jones S, Leary RJ, Lin JC, Boca SM, Carter H, Samayoa J, Bettegowda C, Gallia GL, Jallo GI, Binder ZA, Nikolsky Y, Hartigan J, Smith DR, Gerhard DS, Fults DW, Vandenberg S, Berger MS, Marie SK, Shinjo SM, Clara C, Phillips PC, Minturn JE, Biegel JA, Judkins AR, Resnick AC, Storm PB, Curran T, He Y, Rasheed BA, Friedman HS, Keir ST, McLendon R, Northcott PA, Taylor MD, Burger PC, Riggins GJ, Karchin R, Parmigiani G, Bigner DD, Yan H, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE. Science. 2011 Jan 28;331(6016):435-9. Epub 2010 Dec 16.

Colleen Delaney, MD, MSc (Damon Runyon-Novartis Clinical Investigator ‘07-‘12), Fred Hutchinson Cancer Research Center, Seattle
Combination of HOXB4 and Delta-1 ligand improves expansion of cord blood cells. Watts KL, Delaney C, Humphries RK, Bernstein ID, Kiem HP. Blood. 2010 Dec 23;116(26):5859-66.

Andrew G. Dillin, PhD (Fellowship Award Committee, Damon Runyon Fellow ‘99-‘01), Salk Institute for Biological Studies, La Jolla, and
Mondira Kundu, MD, PhD (Damon Runyon Fellow ‘00-‘03), St. Jude Children’s Research Hospital, Memphis
Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy. Egan DF, Shackelford DB, Mihaylova MM, Gelino SR, Kohnz RA, Mair W, Vasquez DS, Joshi A, Gwinn DM, Taylor R, Asara JM, Fitzpatrick J, Dillin A, Viollet B, Kundu M, Hansen M, Shaw RJ. Science. 2010 Dec 23.

Sandra E. Encalada, PhD (Damon Runyon Fellow ‘04-‘07), University of California, San Diego
Stable Kinesin and Dynein assemblies drive the axonal transport of Mammalian prion protein vesicles. Encalada SE, Szpankowski L, Xia CH, Goldstein LS. Cell. 2011 Feb 18;144(4):551-65.

Dean Felsher, MD, PhD (Damon Runyon-Lilly Clinical Investigator ‘03-‘08), Stanford University, Stanford
MYC Phosphorylation, Activation, and Tumorigenic Potential in Hepatocellular Carcinoma are Regulated by HMG-CoA Reductase. Cao Z, Fan-Minogue H, Bellovin DI, Yevtodiyenko A, Arzeno J, Yang Q, Gambhir SS, Felsher DW. Cancer Res. 2011 Jan 24.

Rafael Fonseca, MD (Damon Runyon-Lilly Clinical Investigator ‘00-‘05), Mayo Clinic, Scottsdale
Progressive but previously untreated CLL patients with greater array CGH complexity exhibit a less durable response to chemoimmunotherapy. Kay NE, Eckel-Passow JE, Braggio E, Vanwier S, Shanafelt TD, Van Dyke DL, Jelinek DF, Tschumper RC, Kipps T, Byrd JC, Fonseca R. Cancer Genet Cytogenet. 2010 Dec;203(2):161-8.

and William C. Hahn, MD, PhD (Damon Runyon Fellow ‘98-‘99), Dana-Farber Cancer Institute, Boston, and
Matthew Meyerson, MD, PhD (Damon Runyon Fellow ‘95-‘98), Dana-Farber Cancer Institute, Boston
Initial genome sequencing and analysis of multiple myeloma. Chapman MA, Lawrence MS, Keats JJ, Cibulskis K, Sougnez C, Schinzel AC, Harview CL, Brunet JP, Ahmann GJ, Adli M, Anderson KC, Ardlie KG, Auclair D, Baker A, Bergsagel PL, Bernstein BE, Drier Y, Fonseca R, Gabriel SB, Hofmeister CC, Jagannath S, Jakubowiak AJ, Krishnan A, Levy J, Liefeld T, Lonial S, Mahan S, Mfuko B, Monti S, Perkins LM, Onofrio R, Pugh TJ, Rajkumar SV, Ramos AH, Siegel DS, Sivachenko A, Stewart AK, Trudel S, Vij R, Voet D, Winckler W, Zimmerman T, Carpten J, Trent J, Hahn WC, Garraway LA, Meyerson M, Lander ES, Getz G, Golub TR. Nature. 2011 Mar 24;471(7339):467-72.

Elaine V. Fuchs, PhD (Damon Runyon Board Member, Damon Runyon Fellow ‘77-‘79), The Rockefeller University, New York
Specific MicroRNAs Are Preferentially Expressed by Skin Stem Cells To Balance Self-Renewal and Early Lineage Commitment. Zhang L, Stokes N, Polak L, Fuchs E. Cell Stem Cell. 2011 Mar 4;8(3):294-308.
Dynamics between stem cells, niche, and progeny in the hair follicle. Hsu YC, Pasolli HA, Fuchs E. Cell. 2011 Jan 7;144(1):92-105. Asymmetric cell divisions promote Notch-dependent epidermal differentiation. Williams SE, Beronja S, Pasolli HA, Fuchs E. Nature. 2011 Feb 17;470(7334):353-8.
EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair. Ezhkova E, Lien WH, Stokes N, Pasolli HA, Silva JM, Fuchs E. Genes Dev. 2011 Mar 1;25(5):485-98.

Nathanael S. Gray, PhD (Damon Runyon-Rachleff Innovator ‘08-‘10), Dana-Farber Cancer Institute, Boston
Discovery of a benzo[e]pyrimido-[5,4-b][1,4]diazepin-6(11H)-one as a Potent and Selective Inhibitor of Big MAP Kinase 1. Deng X, Yang Q, Kwiatkowski N, Sim T, McDermott U, Settleman JE, Lee JD, Gray NS. ACS Med Chem Lett. 2011 Mar 10;2(3):195-200.
Characterization of a selective inhibitor of the Parkinson’s disease kinase LRRK2. Deng X, Dzamko N, Prescott A, Davies P, Liu Q, Yang Q, Lee JD, Patricelli MP, Nomanbhoy TK, Alessi DR, Gray NS. Nat Chem Biol. 2011 Apr;7(4):203-5.

Gregory J. Hannon, PhD (Damon Runyon Fellow ‘92-‘94, Innovation Award Committee Member), Cold Spring Harbor Laboratory, Cold Spring Harbor
Functional Identification of Optimized RNAi Triggers Using a Massively Parallel Sensor Assay. Fellmann C, Zuber J, McJunkin K, Chang K, Malone CD, Dickins RA, Xu Q, Hengartner MO, Elledge SJ, Hannon GJ, Lowe SW. Mol Cell. 2011 Mar 18;41(6):733-46.

John V. Heymach, MD, PhD (Damon Runyon-Lilly Clinical Investigator ‘04-‘09), The University of Texas MD Anderson Cancer Center, Houston
Upregulated stromal EGFR and vascular remodeling in mouse xenograft models of angiogenesis inhibitor-resistant human lung adenocarcinoma. Cascone T, Herynk MH, Xu L, Du Z, Kadara H, Nilsson MB, Oborn CJ, Park YY, Erez B, Jacoby JJ, Lee JS, Lin HY, Ciardiello F, Herbst RS, Langley RR, Heymach JV. J Clin Invest. 2011 Mar 23. pii: 42405.

Darrell J. Irvine, PhD (Damon Runyon Fellow ‘00-‘01), MIT, Cambridge
Interbilayer-crosslinked multilamellar vesicles as synthetic vaccines for potent humoral and cellular immune responses. Moon JJ, Suh H, Bershteyn A, Stephan MT, Liu H, Huang B, Sohail M, Luo S, Ho Um S, Khant H, Goodwin JT, Ramos J, Chiu W, Irvine DJ. Nat Mater. 2011 Mar;10(3):243-51.

Daniel F. Jarosz, PhD (Damon Runyon Fellow ‘08-‘10), Whitehead Institute, Cambridge
Hsp90 and environmental stress transform the adaptive value of natural genetic variation. Jarosz DF, Lindquist S. Science. 2010 Dec 24;330(6012):1820-4.

Vassiliki Karantza, MD, PhD (Damon Runyon Clinical Investigator ‘08-‘11), University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway
Autophagy as a therapeutic target in cancer. Chen N, Karantza V. Cancer Biol Ther. 2011 Jan 15;11(2):157-68. Keratins in health and cancer: more than mere epithelial cell markers. V Karantza. Oncogene. 2011 Jan 13;30(2):127-38.

and Eileen P. White, PhD (Damon Runyon Fellow ‘83-‘85), Rutgers University, New Brunswick
Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Guo JY, Chen HY, Mathew R, Fan J, Strohecker AM, Karsli-Uzunbas G, Kamphorst JJ, Chen G, Lemons JM, Karantza V, Coller HA, Dipaola RS, Gelinas C, Rabinowitz JD, White E. Genes Dev. 2011 Mar 1;25(5):460-70.

Katrin Karbstein, PhD (Damon Runyon Fellow ‘04-‘06), Scripps Research Institute, Jupiter
An RNA conformational switch regulates pre-18S rRNA cleavage. Lamanna AC, Karbstein K. J Mol Biol. 2011 Jan 7;405(1):3-17.

Ken S. Lau, PhD (Robert Black Fellow ‘09-‘11), Massachusetts General Hospital, Charlestown, and
Kevin M. Haigis, PhD (Damon Runyon Fellow ‘03-‘05), Massachusetts General Hospital, Charlestown
In Vivo Systems Analysis Identifies Spatial and Temporal Aspects of the Modulation of TNF-{alpha}-Induced Apoptosis and Proliferation by MAPKs. Lau KS, Juchheim AM, Cavaliere KR, Philips SR, Lauffenburger DA, Haigis KM. Sci Signal. 2011 Mar 22;4(165):ra16.

David E. Lebwohl, MD (Damon Runyon Fellow ‘86-‘87), Novartis Oncology, Florham Park
Everolimus for advanced pancreatic neuroendocrine tumors. Yao JC, Shah MH, Ito T, Bohas CL, Wolin EM, Van Cutsem E, Hobday TJ, Okusaka T, Capdevila J, de Vries EG, Tomassetti P, Pavel ME, Hoosen S, Haas T, Lincy J, Lebwohl D, Öberg K; RAD001 in Advanced Neuroendocrine Tumors, Third Trial (RADIANT-3) Study Group. N Engl J Med. 2011 Feb 10;364(6):514-23.

Jun O. Liu, PhD (Damon Runyon Fellow ‘91-‘93), Johns Hopkins University, Baltimore, and
James A. Goodrich, PhD (Damon Runyon Fellow ‘92-‘94), University of Colorado, Boulder
XPB, a subunit of TFIIH, is a target of the natural product triptolide. Titov DV, Gilman B, He QL, Bhat S, Low WK, Dang Y, Smeaton M, Demain AL, Miller PS, Kugel JF, Goodrich JA, Liu JO. Nat Chem Biol. 2011 Mar;7(3):182-8.

Patrick J. Lupardus, PhD (Damon Runyon Fellow ‘06-‘09), Stanford University, Stanford
Defining an allosteric circuit in the cysteine protease domain of Clostridium difficile toxins. Shen A, Lupardus PJ, Gersch MM, Puri AW, Albrow VE, Garcia KC, Bogyo M. Nat Struct Mol Biol. 2011 Mar;18(3):364-71.
Structural snapshots of full-length Jak1, a transmembrane gp130/IL-6/IL-6Rα cytokine receptor complex, and the receptor-Jak1 holocomplex. Lupardus PJ, Skiniotis G, Rice AJ, Thomas C, Fischer S, Walz T, Garcia KC. Structure. 2011 Jan 12;19(1):45-55.

Ivan Maillard, MD, PhD (Damon Runyon-Rachleff Innovator ‘09-‘11), University of Michigan, Ann Arbor, and
Yi Zhang, MD, PhD (Damon Runyon-Rachleff Innovator ‘09-‘11), University of Michigan, Ann Arbor
Notch signaling is a critical regulator of allogeneic CD4+ T-cell responses mediating graft-versus-host disease. Zhang Y, Sandy AR, Wang J, Radojcic V, Shan GT, Tran IT, Friedman A, Kato K, He S, Cui S, Hexner E, Frank DM, Emerson SG, Pear WS, Maillard I. Blood. 2011 Jan 6;117(1):299-308.

Sridhar Mani, MD (Damon Runyon-Lilly Clinical Investigator ‘02-‘07), Albert Einstein College of Medicine, Bronx
Acetylation of pregnane X receptor protein determines selective function independent of ligand activation. Biswas A, Pasquel D, Tyagi RK, Mani S. Biochem Biophys Res Commun. 2011 Mar 18;406(3):371-6.

Pierre P. Massion, MD (Damon Runyon-Lilly Clinical Investigator ‘03-‘08), Vanderbilt University Medical Center, Nashville
Existing general population models inaccurately predict lung cancer risk in patients referred for surgical evaluation. Isbell JM, Deppen S, Putnam JB Jr, Nesbitt JC, Lambright ES, Dawes A, Massion PP, Speroff T, Jones DR, Grogan EL. Ann Thorac Surg. 2011 Jan;91(1):227-33.

Igor Matushansky, MD, PhD (Gordon Family Clinical Investigator ‘10-‘13), Columbia University, New York
Chromatin structure predicts epigenetic therapy responsiveness in sarcoma. Mills J, Hricik T, Siddiqi S, Matushansky I. Mol Cancer Ther. 2011 Feb;10(2):313-24.

Sarkis K. Mazmanian, PhD (Damon Runyon-Rachleff Innovator ‘08-‘10), California Institute of Technology, Pasadena
Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis. Lee YK, Menezes JS, Umesaki Y, Mazmanian SK. Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1:4615-22.

Esteban O. Mazzoni, PhD (Damon Runyon Fellow ‘07-‘10), Columbia University, New York
Mir-17-3p controls spinal neural progenitor patterning by regulating olig2/irx3 cross-repressive loop. Chen JA, Huang YP, Mazzoni EO, Tan GC, Zavadil J, Wichterle H. Neuron. 2011 Feb 24;69(4):721-35.
Ligand-dependent dynamics of retinoic acid receptor binding during early neurogenesis. Mahony S, Mazzoni EO, McCuine S, Young RA, Wichterle H, Gifford DK. Genome Biol. 2011 Jan 13;12(1):R2.

and Taiowa A. Montgomery, PhD (Damon Runyon Fellow ‘09-‘12), Massachusetts General Hospital, Boston, and
Harrison W. Gabel, PhD (Damon Runyon Fellow ‘10-‘12), Harvard Medical School, Boston, and
Carolyn M. Phillips, PhD (Damon Runyon Marion Abbe Fellow ‘08-‘11), Massachusetts General Hospital, Boston
mut-16 and other mutator class genes modulate 22G and 26G siRNA pathways in Caenorhabditis elegans. Zhang C, Montgomery TA, Gabel HW, Fischer SE, Phillips CM, Fahlgren N, Sullivan CM, Carrington JC, Ruvkun G. Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1201-8.

Elahe A. Mostaghel, MD, PhD (Damon Runyon-Genentech Clinical Investigator ‘08-‘11), Fred Hutchinson Cancer Research Center, Seattle
Expression of SLCO transport genes in castration resistant prostate cancer and impact of genetic variation in SCLO1B3 and SLCO2B1 on prostate cancer outcomes. Wright JL, Kwon EM, Ostrander EA, Montgomery B, Line DW, Vessella RL, Stanford JL, Mostaghel EA. Cancer Epidemiol Biomarkers Prev. 2011 Jan 25.

Jared T. Nordman, PhD (Damon Runyon-HHMI Fellow ‘09-‘12), Whitehead Institute, Cambridge
Developmental control of the DNA replication and transcription programs. Nordman J, Li S, Eng T, Macalpine D, Orr-Weaver TL. Genome Res. 2010 Dec 22.
Identification of functional elements and regulatory circuits by Drosophila modENCODE. modENCODE Consortium, Nordman J, et al. Science. 2010 Dec 24;330(6012):1787-97. Epub 2010 Dec 22.

James M. Olson, MD, PhD (Damon Runyon-Lilly Clinical Investigator ‘02-‘07), Fred Hutchinson Cancer Research Center, Seattle
Chemical Re-engineering of Chlorotoxin Improves Bioconjugation Properties for Tumor Imaging and Targeted Therapy. Akcan M, Stroud MR, Hansen SJ, Clark RJ, Daly NL, Craik DJ, Olson JM. J Med Chem. 2011 Jan 6.

John M. Pagel, MD, PhD (Damon Runyon-Lilly Clinical Investigator ‘05-‘10), Fred Hutchinson Cancer Research Center, Seattle
Impact of Pretransplantation Minimal Residual Disease, As Detected by Multiparametric Flow Cytometry, on Outcome of Myeloablative Hematopoietic Cell Transplantation for Acute Myeloid Leukemia. Walter RB, Gooley TA, Wood BL, Milano F, Fang M, Sorror ML, Estey EH, Salter AI, Lansverk E, Chien JW, Gopal AK, Appelbaum FR, Pagel JM. J Clin Oncol. 2011 Jan 31.

Jeremy N. Rich, MD (Damon Runyon-Lilly Clinical Investigator ‘04-‘09), Cleveland Clinic, Cleveland
L1CAM regulates DNA damage checkpoint response of glioblastoma stem cells through NBS1. Cheng L, Wu Q, Huang Z, Guryanova OA, Huang Q, Shou W, Rich JN, Bao S. EMBO J. 2011 Mar 2;30(5):800-13.

Deubiquitylase HAUSP stabilizes REST and promotes maintenance of neural progenitor cells. Huang Z, Wu Q, Guryanova OA, Cheng L, Shou W, Rich JN, Bao S. Nat Cell Biol. 2011 Feb;13(2):142-52.

Muneesh Tewari, MD, PhD (Damon Runyon-Rachleff Innovator ‘09-‘11), Fred Hutchinson Cancer Research Center, Seattle
Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma. Arroyo JD, Chevillet JR, Kroh EM, Ruf IK, Pritchard CC, Gibson DF, Mitchell PS, Bennett CF, Pogosova-Agadjanyan EL, Stirewalt DL, Tait JF, Tewari M. Proc Natl Acad Sci U S A. 2011 Mar 7.

Carl S. Thummel, PhD (Damon Runyon Fellow ‘83-‘84), University of Utah, Salt Lake City
The Drosophila estrogen-related receptor directs a metabolic switch that supports developmental growth. Tennessen JM, Baker KD, Lam G, Evans J, Thummel CS. Cell Metab. 2011 Feb 2;13(2):139-48.

Robert H. Vonderheide MD, PhD (Damon Runyon-Lilly Clinical Investigator ‘00-‘05), University of Pennsylvania, Philadelphia
CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans. Beatty GL, Chiorean EG, Fishman MP, Saboury B, Teitelbaum UR, Sun W, Huhn RD, Song W, Li D, Sharp LL, Torigian DA, O’Dwyer PJ, Vonderheide RH. Science. 2011 Mar 25;331(6024):1612-6.

Catherine J. Wu, MD (Damon Runyon Clinical Investigator ‘07-‘12), Dana-Farber Cancer Institute, Boston
Effective posttransplant antitumor immunity is associated with TLR-stimulating nucleic acid-immunoglobulin complexes in humans. Lin Y, Zhang L, Cai AX, Lee M, Zhang W, Neuberg D, Canning CM, Soiffer RJ, Alyea EP, Ritz J, Hacohen N, Means TK, Wu CJ. J Clin Invest. 2011 Mar 14.

Hai Yan, MD, PhD (Damon Runyon Scholar ‘05-‘07), Duke University Medical Center, Durham
Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome. Reitman ZJ, Jin G, Karoly ED, Spasojevic I, Yang J, Kinzler KW, He Y, Bigner DD, Vogelstein B, Yan H. Proc Natl Acad Sci U S A. 2011 Feb 2.

Jing Yang, PhD (Damon Runyon Fellow ‘00-‘03), University of California San Diego, La Jolla
Snail2 is an essential mediator of Twist1-induced epithelial mesenchymal transition and metastasis. Casas E, Kim J, Bendesky A, Ohno-Machado L, Wolfe CJ, Yang J. Cancer Res. 2011 Jan 1;71(1):245-54.

Yi Zhang, MD, PhD (Damon Runyon-Rachleff Innovator ‘09-‘11), University of Michigan, Ann Arbor
Identification of stem cell transcriptional programs normally expressed in embryonic and neural stem cells in alloreactive CD8+ T cells mediating graft-versus-host disease. Kato K, Cui S, Kuick R, Mineishi S, Hexner E, Ferrara JL, Emerson SG, Zhang Y. Biol Blood Marrow Transplant. 2010 Jun;16(6):751-71.

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