In this issue:  Upcoming Deadlines and Events  |  Awards and Honors  |  Publications

Science Update: July - September 2010

Dear Damon Runyon Scientists,

We just returned from our tenth annual Damon Runyon Fellows’ Retreat, which took place on Cape Cod, Massachusetts. Sixty Fellows attended, along with several alumni, Clinical Investigators, scientific committee members and Damon Runyon staff. As always, it was a terrific gathering: the highest-quality science was presented, valuable networking took place, and new friendships and collaborations were developed.

This month we will be selecting the finalists for the Damon Runyon-Rachleff Innovation Award, and in November we will select a new class of Fellows and the first recipients of the new Dale F. Frey Award for Breakthrough Scientists.

Please see below for the latest update on exciting news and findings from your fellow Damon Runyon scientists – current and former. These are just the publications and awards that we are aware of, so we apologize if we have not included your work. Lay summaries of some of this work are posted on the News page of our website, along with additional news about our Scientific Committee and Board members.

Thanks again to those of you who have sent us updates on your recent progress.

Please stay in touch, and enjoy the fall!

Best regards,

Yung

Yung S. Lie, PhD
Scientific Director
Damon Runyon Cancer Research Foundation
One Exchange Plaza
55 Broadway, Suite 302
New York, NY 10006
212.455.0521
212.455.0529 FAX
yung.lie@damonrunyon.org

UPCOMING DEADLINES and EVENTS

Physician-Scientist Career Development Meeting
September 3-5, 2010, at the New York Academy of Sciences, New York City
(in collaboration with Howard Hughes Medical Institute, Burroughs Wellcome Fund and Doris Duke Charitable Foundation)

AWARDS and HONORS

2010 Lasker~DeBakey Clinical Medical Research Award:
Napoleone Ferrara, MD (Damon Runyon-Rachleff Innovation Award Committee Member), Genentech, South San Francisco

American Society for Clinical Oncology (ASCO) Foundation Advanced Clinical Research Award:
David G. Kirsch, MD, PhD (Damon Runyon-Rachleff Innovator ‘08-‘10), Duke University Medical Center, Durham

2009 Research Society on Alcoholism Distinguished Researcher Award; 2007 Elected Fellow of the American Association for the Advancement of Science:
Howard J. Edenberg, PhD (Fellow ‘73-‘75), Indiana University School of Medicine, Indianapolis

NIH Transformative R01 Award:
Madhav Dhodapkar, MD (Damon Runyon-Lilly Clinical Investigator ‘02-‘07), Yale Cancer Center, New Haven
Richard A. Flavell, PhD (Former Fellowship Award Committee Member), Yale University School of Medicine, New Haven
X. Sunney Xie, PhD (Current Fellowship Sponsor), Harvard University, Cambridge

NIH Pioneer Award:
Pamela J. Bjorkman, PhD (Former Fellowship Sponsor), California Institute of Technology, Pasadena
Stephen W. Fesik, PhD (Former Innovation Award Committee Member), Vanderbilt University School of Medicine, Nashville
Jun O. Liu, PhD (Fellow ‘91-‘93), the Johns Hopkins University School of Medicine, Baltimore

PUBLICATIONS

Renier J. Brentjens, MD, PhD (Damon Runyon-Lilly Clinical Investigator ‘06-‘11), Memorial Sloan-Kettering Cancer Center, New York
Successful eradication of established peritoneal ovarian tumors in SCID-Beige mice following adoptive transfer of T cells genetically targeted to the MUC16 antigen. Chekmasova AA, Rao TD, Nikhamin Y, Park KJ, Levine DA, Spriggs DR, Brentjens RJ. Clin Cancer Res. 2010 Jul 15;16(14):3594-606.

and Marcel R.M. van den Brink, MD, PhD (Scholar ‘01-‘04), Memorial Sloan-Kettering Cancer Center, New York
Concurrent visualization of trafficking, expansion, and activation of T lymphocytes and T-cell precursors in vivo. Na IK, Markley JC, Tsai JJ, Yim NL, Beattie BJ, Klose AD, Holland AM, Ghosh A, Rao UK, Stephan MT, Serganova I, Santos EB, Brentjens RJ, Blasberg RG, Sadelain M, van den Brink MR. Blood. 2010 Sep 16;116(11):e18-25.

Patrick A. Brown, MD (Damon Runyon-Lilly Clinical Investigator ‘06-‘11), The Johns Hopkins University, Baltimore
Promoter hypermethylation in MLL-r infant acute lymphoblastic leukemia: biology and therapeutic targeting. Schafer E, Irizarry R, Negi S, McIntyre E, Small D, Figueroa ME, Melnick A, Brown P. Blood. 2010 Jun 10;115(23):4798-809.

Kara L. Cerveny, PhD (Fellow ‘05-‘08), University College London, London
The zebrafish flotte lotte mutant reveals that the local retinal environment promotes the differentiation of proliferating precursors emerging from their stem cell niche. Cerveny KL, Cavodeassi F, Turner KJ, de Jong-Curtain TA, Heath JK, Wilson SW. Development. 2010 Jul;137(13):2107-15.

Andrew T. Chan, MD, MPH (Damon Runyon Clinical Investigator ‘08-‘11), Massachusetts General Hospital, Boston
Cathepsin B Expression and Survival in Colon Cancer: Implications for Molecular Detection of Neoplasia. Chan AT, Baba Y, Shima K, Nosho K, Chung DC, Hung KE, Mahmood U, Madden K, Poss K, Ranieri AC, Shue DS, Kucherlapati RS, Fuchs CS, Ogino S. Cancer Epidemiol Biomarkers Prev. 2010 Sep 10.

Howard Y. Chang, MD, PhD (Scholar ‘06-‘08), Stanford University School of Medicine, Stanford
Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes. Tsai MC, Manor O, Wan Y, Mosammaparast N, Wang JK, Lan F, Shi Y, Segal E, Chang HY. Science. 2010 Jul 8.

Christine H. Chung, MD (Damon Runyon-Lilly Clinical Investigator ‘05-‘10), The Johns Hopkins University, Baltimore
Regulation of heparin-binding EGF-like growth factor by miR-212 and acquired cetuximab-resistance in head and neck squamous cell carcinoma. Hatakeyama H, Cheng H, Wirth P, Counsell A, Marcrom SR, Wood CB, Pohlmann PR, Gilbert J, Murphy B, Yarbrough WG, Wheeler DL, Harari PM, Guo Y, Shyr Y, Slebos RJ, Chung CH. PLoS One. 2010 Sep 13;5(9):e12702.

Andrea L. Cox, MD, PhD (Damon Runyon-Lilly Clinical Investigator ‘06-‘11), The Johns Hopkins University, Baltimore
Increased natural killer cell cytotoxicity and NKp30 expression protects against hepatitis C virus infection in high-risk individuals and inhibits replication in vitro. Golden-Mason L, Cox AL, Randall JA, Cheng L, Rosen HR. Hepatology. 2010 Aug 19.

Jason M. Crawford, PhD (Fellow ‘09-‘12), Harvard Medical School, Cambridge
Exploiting a global regulator for small molecule discovery in Photorhabdus luminescens. Kontnik R, Crawford JM, Clardy J. ACS Chem Biol. 2010 Jul 16;5(7):659-65.

Alexandra M. Deaconescu, PhD (HHMI Fellow ‘08-‘10), Brandeis University, Waltham
Okada, K., Bartolini, F., Deaconescu, A.M., Moseley, J.B., Dogic, Z., Grigorieff, N., Gundersen, G.G., Goode, B.L. The tumor suppressor protein APC is a potent nucleator of actin assembly that synergizes with the formin mDia1. (2010) J Cell Biol 189:1087-96

Colleen Delaney, MD, MSc (Damon Runyon-Novartis Clinical Investigator ‘07-‘12), Fred Hutchinson Cancer Research Center, Seattle
Allogeneic hematopoietic cell transplantation for hematological malignancy: relative risks and benefits of double umbilical cord blood. Brunstein CG, Gutman JA, Weisdorf DJ, Woolfrey AE, Defor TE, Gooley TA, Verneris MR, Appelbaum FR, Wagner JE, Delaney C. Blood. 2010 Aug 4.

Charles G. Drake, MD, PhD (Damon Runyon-Lilly Clinical Investigator ‘04-‘09), The Johns Hopkins University, Baltimore
Prostate cancer as a model for tumour immunotherapy. Drake CG. Nat Rev Immunol. 2010 Aug;10(8):580-93.

Phillip G. Febbo, MD (Damon Runyon-Lilly Clinical Investigator ‘05-‘10), Duke University Medical Center, Durham
Immune signatures predict prognosis in localized cancer. Hsu DS, Kim MK, Balakumaran BS, Acharya CR, Anders CK, Clay T, Lyerly HK, Drake CG, Morse MA, Febbo PG. Cancer Invest. 2010 Aug;28(7):765-73.

Dean W. Felsher, MD, PhD (Damon Runyon-Lilly Clinical Investigator ‘03-‘08), Stanford University School of Medicine, Stanford
Noninvasive molecular imaging of c-Myc activation in living mice. Fan-Minogue H, Cao Z, Paulmurugan R, Chan CT, Massoud TF, Felsher DW, Gambhir SS. Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15892-7.

Rafael Fonseca, MD (Damon Runyon-Lilly Clinical Investigator ‘00-‘05), Mayo Clinic, Scottsdale
DNA methylation analysis determines the high frequency of genic hypomethylation and low frequency of hypermethylation events in plasma cell tumors. Salhia B, Baker A, Ahmann G, Auclair D, Fonseca R, Carpten J. Cancer Res. 2010 Sep 1;70(17):6934-44.

Elaine V. Fuchs, PhD (Damon Runyon Board Member, Fellow ‘77-‘79), The Rockefeller University, New York
Rapid functional dissection of genetic networks via tissue-specific transduction and RNAi in mouse embryos. Beronja S, Livshits G, Williams S, Fuchs E. Nat Med. 2010 Jul;16(7):821-7.

Nathanael S. Gray, PhD (Damon Runyon-Rachleff Innovator ‘08-‘10), Dana-Farber Cancer Institute, Boston
Pharmacological inhibition of BMK1 suppresses tumor growth through promyelocytic leukemia protein. Yang Q, Deng X, Lu B, Cameron M, Fearns C, Patricelli MP, Yates JR 3rd, Gray NS, Lee JD. Cancer Cell. 2010 Sep 14;18(3):258-67.

Expanding the Diversity of Allosteric Bcr-Abl Inhibitors. Deng X, Okram B, Ding Q, Zhang J, Choi Y, Adrián FJ, Wojciechowski A, Zhang G, Che J, Bursulaya B, Cowan-Jacob SW, Rummel G, Sim T, Gray NS. J Med Chem. 2010 Sep 9.

Gregory J. Hannon, PhD (Damon Runyon Fellow ‘92-‘94, Fellowship Sponsor and Innovation Award Committee Member), Cold Spring Harbor Laboratory, Cold Spring Harbor
Canonical and alternate functions of the microRNA biogenesis machinery. Chong MM, Zhang G, Cheloufi S, Neubert TA, Hannon GJ, Littman DR. Genes Dev. 2010 Sep 1;24(17):1951-60.

Reginald Hill, PhD (Fellow ‘06-‘09), David Geffen School of Medicine at University of California, Los Angeles
PTEN loss accelerates KrasG12D-induced pancreatic cancer development. Hill R, Calvopina JH, Kim C, Wang Y, Dawson DW, Donahue TR, Dry S, Wu H. Cancer Res. 2010 Sep 15;70(18):7114-24.

Darrell J. Irvine, PhD (Fellow ‘00-‘01), Massachusetts Institute of Technology, Cambridge
Therapeutic cell engineering with surface-conjugated synthetic nanoparticles. Stephan MT, Moon JJ, Um SH, Bershteyn A, Irvine DJ. Nat Med. 2010 Sep;16(9):1035-41.

Vassiliki Karantza, MD, PhD (Damon Runyon Clinical Investigator ‘08-‘11), Cancer Institute of New Jersey, New Brunswick
Keratins in health and cancer: more than mere epithelial cell markers. Karantza V. Oncogene. 2010 Oct 4.

The protein kinase Pak4 disrupts mammary acinar architecture and promotes mammary tumorigenesis. Liu Y, Chen N, Cui X, Zheng X, Deng L, Price S, Karantza V, Minden A. Oncogene. 2010 Aug 9.

Phase I study of gemcitabine, docetaxel and imatinib in refractory and relapsed solid tumors. Saraiya B, Chugh R, Karantza V, Mehnert J, Moss RA, Savkina N, Stein MN, Baker LH, Chenevert T, Poplin EA. Invest New Drugs. 2010 Aug 10.

Autophagy regulates keratin 8 homeostasis in mammary epithelial cells and in breast tumors. Kongara S, Kravchuk O, Teplova I, Lozy F, Schulte J, Moore D, Barnard N, Neumann CA, White E, Karantza V. Mol Cancer Res. 2010 Jun;8(6):873-84.

William Y. Kim, MD (Damon Runyon-Merck Clinical Investigator ‘09-‘12), University of North Carolina, Chapel Hill
Integrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumors. Carretero J, Shimamura T, Rikova K, Jackson AL, Wilkerson MD, Borgman CL, Buttarazzi MS, Sanofsky BA, McNamara KL, Brandstetter KA, Walton ZE, Gu TL, Silva JC, Crosby K, Shapiro GI, Maira SM, Ji H, Castrillon DH, Kim CF, García-Echeverría C, Bardeesy N, Sharpless NE, Hayes ND, Kim WY, Engelman JA, Wong KK. Cancer Cell. 2010 Jun 15;17(6):547-59.

David G. Kirsch, MD, PhD (Damon Runyon-Rachleff Innovator ‘08-‘10), Duke University Medical Center, Durham
Primary tumor genotype is an important determinant in identification of lung cancer propagating cells. Curtis SJ, Sinkevicius KW, Li D, Lau AN, Roach RR, Zamponi R, Woolfenden AE, Kirsch DG, Wong KK, Kim CF. Cell Stem Cell. 2010 Jul 2;7(1):127-33.

Jennifer L. Malin, MD, PhD (Damon Runyon-Lilly Clinical Investigator ‘01-‘05), David Geffen School of Medicine at University of California, Los Angeles
Quality of care for breast cancer for uninsured women in california under the breast and cervical cancer prevention treatment act. Malin JL, Diamant AL, Leake B, Liu Y, Thind A, Kahn KL, Schneider EC, Epstein AM, Maly RC. J Clin Oncol. 2010 Jul 20;28(21):3479-84.

Kurt W. Marek, PhD (Fellow ‘05-‘08), University of California San Diego, La Jolla
cJun integrates calcium activity and tlx3 expression to regulate neurotransmitter specification. Marek KW, Kurtz LM, Spitzer NC. Nat Neurosci. 2010 Aug;13(8):944-50.

Esteban O. Mazzoni, PhD (Fellow ‘07-‘10), Columbia University, New York
Functional diversity of ESC-derived motor neuron subtypes revealed through intraspinal transplantation. Peljto M, Dasen JS, Mazzoni EO, Jessell TM, Wichterle H. Cell Stem Cell. 2010 Sep 3;7(3):355-66.

Global control of motor neuron topography mediated by the repressive actions of a single hox gene. Jung H, Lacombe J, Mazzoni EO, Liem KF Jr, Grinstein J, Mahony S, Mukhopadhyay D, Gifford DK, Young RA, Anderson KV, Wichterle H, Dasen JS. Neuron. 2010 Sep 9;67(5):781-96.

Grant A. McArthur, MBBS, PhD, FRACP (Fellow ‘95-‘98), Peter MacCallum Cancer Institute, Melbourne, Australia, NEJM
Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma. Bollag G, Hirth P, Tsai J, Zhang J, Ibrahim PN, Cho H, Spevak W, Zhang C, Zhang Y, Habets G, Burton EA, Wong B, Tsang G, West BL, Powell B, Shellooe R, Marimuthu A, Nguyen H, Zhang KY, Artis DR, Schlessinger J, Su F, Higgins B, Iyer R, D’Andrea K, Koehler A, Stumm M, Lin PS, Lee RJ, Grippo J, Puzanov I, Kim KB, Ribas A, McArthur GA, Sosman JA, Chapman PB, Flaherty KT, Xu X, Nathanson KL, Nolop K. Nature. 2010 Sep 30;467(7315):596-9.

Inhibition of mutated, activated BRAF in metastatic melanoma. Flaherty KT, Puzanov I, Kim KB, Ribas A, McArthur GA, Sosman JA, O’Dwyer PJ, Lee RJ, Grippo JF, Nolop K, Chapman PB. N Engl J Med. 2010 Aug 26;363(9):809-19.

C. Ryan Miller, MD, PhD (Damon Runyon-Genentech Clinical Investigator ‘09-‘12), University of North Carolina, Chapel Hill
Lung Squamous Cell Carcinoma mRNA Expression Subtypes Are Reproducible, Clinically Important, and Correspond to Normal Cell Types. Wilkerson MD, Yin X, Hoadley KA, Liu Y, Hayward MC, Cabanski CR, Muldrew K, Miller CR, Randell SH, Socinski MA, Parsons AM, Funkhouser WK, Lee CB, Roberts PJ, Thorne L, Bernard PS, Perou CM, Hayes DN. Clin Cancer Res. 2010 Oct 1;16(19):4864-4875.

William W. Navarre, PhD (Fellow ‘00-‘03), University of Toronto, Ontario
PoxA, YjeK, and Elongation Factor P Coordinately Modulate Virulence and Drug Resistance in Salmonella enterica. Navarre WW, Zou SB, Roy H, Xie JL, Savchenko A, Singer A, Edvokimova E, Prost LR, Kumar R, Ibba M, Fang FC. Mol Cell. 2010 Jul 30;39(2):209-221.

Phillip A. Newmark, PhD (Fellow ‘95-‘97 and Scholar ‘03-‘05) at the University of Illinois, Urbana-Chanpaign, Urbana, Illinois
A functional genomic screen in planarians identifies novel regulators of germ cell development. Wang Y, Stary JM, Wilhelm JE, Newmark PA. Genes Dev. 2010 Sep 15;24(18):2081-92.

Jeremy N. Rich, MD (Damon Runyon-Lilly Clinical Investigator ‘04-‘09), Cleveland Clinic, Cleveland
Phase II trial of bevacizumab and erlotinib in patients with recurrent malignant glioma. Sathornsumetee S, Desjardins A, Vredenburgh JJ, McLendon RE, Marcello J, Herndon JE, Mathe A, Hamilton M, Rich JN, Norfleet JA, Gururangan S, Friedman HS, Reardon DA. Neuro Oncol. 2010 Aug 17.

Phase II study of metronomic chemotherapy with bevacizumab for recurrent glioblastoma after progression on bevacizumab therapy. Reardon DA, Desjardins A, Peters K, Gururangan S, Sampson J, Rich JN, McLendon R, Herndon JE 2nd, Marcello J, Threatt S, Friedman AH, Vredenburgh JJ, Friedman HS. J Neurooncol. 2010 Sep 19.

John L. Rinn, PhD (Damon Runyon-Rachleff Innovator ‘09-‘11, Fellow ‘05-‘07), Harvard Medical School and the Broad Institute, Boston
DNA methylation and epigenetic control of cellular differentiation. Khavari DA, Sen GL, Rinn JL. Cell Cycle. 2010 Oct 20;9(19).

and Laura D. Attardi, PhD (Scholar ‘02-‘04), Stanford University, Stanford
A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response. Huarte M, Guttman M, Feldser D, Garber M, Koziol MJ, Kenzelmann-Broz D, Khalil AM, Zuk O, Amit I, Rabani M, Attardi LD, Regev A, Lander ES, Jacks T, Rinn JL. Cell. 2010 Aug 6;142(3):409-19.

and Howard Y. Chang, MD, PhD (Scholar ‘06-‘08), Stanford University School of Medicine, Stanford
Genome-wide measurement of RNA secondary structure in yeast. Kertesz M, Wan Y, Mazor E, Rinn JL, Nutter RC, Chang HY, Segal E. Nature. 2010 Sep 2;467(7311):103-7.

Alonzo H. Ross, PhD (Fellow ‘77-‘78), University of Massachusetts Medical School, Worcester
Gamma-secretase inhibitors enhance temozolomide treatment of human gliomas by inhibiting neurosphere repopulation and xenograft recurrence. Gilbert CA, Daou MC, Moser RP, Ross AH. Cancer Res. 2010 Sep 1;70(17):6870-9.

Joel H. Rubenstein, MD (Damon Runyon-Lilly Clinical Investigator ‘07-‘10), University of Michigan, Ann Arbor
Meta-analyses of the effect of symptoms of gastroesophageal reflux on the risk of Barrett’s esophagus. Taylor JB, Rubenstein JH. Am J Gastroenterol. 2010 Aug;105(8):1729, 1730-7.

Julien Sage, PhD (Scholar ‘05-‘07), Stanford University Medical Center, Stanford
Transient inactivation of Rb and ARF yields regenerative cells from postmitotic mammalian muscle. Pajcini KV, Corbel SY, Sage J, Pomerantz JH, Blau HM. Cell Stem Cell. 2010 Aug 6;7(2):198-213.

Sarah E. Siegrist, PhD (Fellow ‘07-‘10), University of California, Berkeley
Inactivation of both Foxo and reaper promotes long-term adult neurogenesis in Drosophila. Siegrist SE, Haque NS, Chen CH, Hay BA, Hariharan IK. Curr Biol. 2010 Apr 13;20(7):643-8.

Raffaella Sordella, PhD (Island Outreach Foundation Innovator ‘10-‘12), Cold Spring Harbor Laboratory, Cold Spring Harbor
TGF-beta IL-6 axis mediates selective and adaptive mechanisms of resistance to molecular targeted therapy in lung cancer. Yao Z, Fenoglio S, Gao DC, Camiolo M, Stiles B, Lindsted T, Schlederer M, Johns C, Altorki N, Mittal V, Kenner L, Sordella R. Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15535-40.

Matthew G. Vander Heiden, MD, PhD (Fellow ‘06-‘08), Harvard Medical School, Boston
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Dang L, White DW, Gross S, Bennett BD, Bittinger MA, Driggers EM, Fantin VR, Jang HG, Jin S, Keenan MC, Marks KM, Prins RM, Ward PS, Yen KE, Liau LM, Rabinowitz JD, Cantley LC, Thompson CB, Vander Heiden MG, Su SM. Nature. 2010 Jun 17;465(7300):966.

and Heather R. Christofk, PhD (Damon Runyon-Rachleff Innovator ‘10-‘12), University of California, Los Angeles
Evidence for an alternative glycolytic pathway in rapidly proliferating cells. Vander Heiden MG, Locasale JW, Swanson KD, Sharfi H, Heffron GJ, Amador-Noguez D, Christofk HR, Wagner G, Rabinowitz JD, Asara JM, Cantley LC. Science. 2010 Sep 17;329(5998):1492-9.

Robert H. Vonderheide, MD, PhD (Damon Runyon-Lilly Clinical Investigator ‘00-‘05), University of Pennsylvania, Philadelphia
Tremelimumab in combination with exemestane in patients with advanced breast cancer and treatment-associated modulation of inducible costimulator expression on patient T cells. Vonderheide RH, LoRusso PM, Khalil M, Gartner EM, Khaira D, Soulieres D, Dorazio P, Trosko JA, Rüter J, Mariani GL, Usari T, Domchek SM. Clin Cancer Res. 2010 Jul 1;16(13):3485-94.

Immune modulation with weekly dosing of an agonist CD40 antibody in a phase I study of patients with advanced solid tumors. Rüter J, Antonia SJ, Burris HA 3rd, Huhn RD, Vonderheide RH. Cancer Biol Ther. 2010 Nov 4;10(10).

Edus H. Warren, MD, PhD (Damon Runyon-Lilly Clinical Investigator ‘00-‘05), Fred Hutchinson Cancer Research Center, Seattle
Overlap and effective size of the human CD8+ T cell receptor repertoire. Robins HS, Srivastava SK, Campregher PV, Turtle CJ, Andriesen J, Riddell SR, Carlson CS, Warren EH. Sci Transl Med. 2010 Sep 1;2(47):47ra64.

Jedd D. Wolchok, MD, PhD (Damon Runyon-Lilly Clinical Investigator ‘03-‘08), Memorial Sloan-Kettering Cancer Center, New York
Improved survival with ipilimumab in patients with metastatic melanoma. Hodi FS, O’Day SJ, McDermott DF, Weber RW, Sosman JA, Haanen JB, Gonzalez R, Robert C, Schadendorf D, Hassel JC, Akerley W, van den Eertwegh AJ, Lutzky J, Lorigan P, Vaubel JM, Linette GP, Hogg D, Ottensmeier CH, Lebbé C, Peschel C, Quirt I, Clark JI, Wolchok JD, Weber JS, Tian J, Yellin MJ, Nichol GM, Hoos A, Urba WJ. N Engl J Med. 2010 Aug 19;363(8):711-23.

Immunologic response to xenogeneic gp100 DNA in melanoma patients: comparison of particle-mediated epidermal delivery with intramuscular injection. Ginsberg BA, Gallardo HF, Rasalan TS, Adamow M, Mu Z, Tandon S, Bewkes BB, Roman RA, Chapman PB, Schwartz GK, Carvajal RD, Panageas KS, Terzulli SL, Houghton AN, Yuan JD, Wolchok JD. Clin Cancer Res. 2010 Aug 1;16(15):4057-65.

Catherine J. Wu, MD (Damon Runyon Clinical Investigator ‘07-‘12), Dana-Farber Cancer Institute, Boston
Syngeneic Donor Hematopoietic Stem Cell Transplantation is Associated with High Rates of Engraftment Syndrome. Koreth J, Biernacki M, Aldridge J, Kim HT, Alyea EP, Armand P, Cutler C, Ho VT, Wu CJ, Antin JH, Soiffer RJ. Biol Blood Marrow Transplant. 2010 Sep 23.

Yi Zhang, MD, PhD (Damon Runyon-Rachleff Innovator ‘09-‘11), University of Michigan, Ann Arbor
Identification of stem cell transcriptional programs normally expressed in embryonic and neural stem cells in alloreactive CD8+ T cells mediating graft-versus-host disease. Kato K, Cui S, Kuick R, Mineishi S, Hexner E, Ferrara JL, Emerson SG, Zhang Y. Biol Blood Marrow Transplant. 2010 Jun;16(6):751-71.

and Ivan Maillard, MD, PhD (Damon Runyon-Rachleff Innovator ‘09-‘11), University of Michigan, Ann Arbor
Notch signaling is a critical regulator of allogeneic CD4+ T cell responses mediating graft-versus-host disease. Zhang Y, Sandy AR, Wang J, Radojcic V, Shan GT, Tran IT, Friedman A, Kato K, He S, Cui S, Hexner E, Frank DM, Emerson SG, Pear WS, Maillard I. Blood. 2010 Sep 24.

> Visit the New Discoveries and Honors page for more.