Damon Runyon Researchers

Meet Our Scientists
Fuguo Jiang, PhD

Dr. Jiang [Merck Fellow] is studying the CRISPR-Cas system, which has been adopted as a robust and versatile platform for genome engineering in human cells as well as other experimental systems. He aims to use a combination of biochemical experiments, mutagenesis, and biophysical approaches to investigate the detailed molecular mechanism of RNA-guided DNA targeting and recognition by CRISPR-Cas9. The results of this research will provide a fundamental understanding of the Cas9 enzyme family and will support its use for site-specific genetic control, including gene therapies against cancers.

Project title: "Molecular mechanisms of guide RNA: target dsDNA binding and PAM recognition by CRISPR-Cas9"
Institution: University of California, Berkeley
Named Award: Merck Fellow
Award Program: Fellow
Sponsor(s) / Mentor(s): Jennifer A. Doudna, PhD
Cancer Type: All Cancers
Research Area: RNA (RNA processing, miRNA and piRNA mechanisms, enzymatic RNAs, etc.)