Damon Runyon Researchers

Dr. McGinty is using protein chemistry and structural biology to study epigenetic changes to the composition and structure of chromatin, the physical state of the DNA in each cell’s genome. These epigenetic modifications are chemical marks that modify the expression of genes without a change in the genetic sequence itself. Divergent patterns of gene expression lead to the development of diverse cell types and functions, and their inappropriate regulation is correlated with many human diseases, especially cancer.