Damon Runyon Researchers

Dr. Nguyen uses advanced fluorescence microscopy to visualize how defined structural changes in chromatin, the condensed form of DNA, affect its association with factors required for transcription initiation—an early and essential step in gene expression. Architectural defects in chromatin are found in many cancers and have been linked to aberrant patterns of gene expression. The results of this research will be important in characterizing the connection between chromatin organization and cancer-associated gene misregulation.