Mingye Feng, PhD

The understanding of the mechanisms by which specific types of immune cells detect and attack tumor cells has enabled the development of promising cancer immunotherapies. Recently, researchers have discovered the important roles of immune cells called macrophages in the surveillance and elimination of tumor cells. Dr. Feng focuses on understanding how cancer cells protect themselves and evade macrophages, and how macrophages recognize cancer cells and target them for elimination.

L. Elizabeth Budde, MD, PhD

Hematopoietic stem cell transplant is the preferred and only curative treatment for most patients with acute myeloid leukemia (AML); however, a significant percentage of patients will eventually relapse. A novel effective therapy option is therefore urgently needed. Dr. Budde [The Jake Wetchler Foundation for Innovative Pediatric Cancer Research Clinical Investigator] is testing a new strategy that uses patients' own immune T cells, which have been modified to specifically target and kill leukemia cells.