Omar Abdel-Wahab, MD

Dr. Abdel-Wahab [Edward P. Evans Foundation Clinical Investigator] specializes in specific blood cancers called myelodysplastic syndrome (MDS) and acute myelogenous leukemia (AML). He recently identified mutations in the gene ASXL1 in patients with MDS and AML. ASXL1 is one of the most commonly mutated genes in MDS patients, and these mutations occur in up to 20% of AML patients. ASXL1 mutations result in a worsened overall survival in MDS and AML patients and contribute to chemotherapy resistance in AML.

Carolyn C. Jackson, MD, MPH

Kaposi sarcoma (KS), a potentially fatal cancer especially in immunodeficient individuals, is caused by human herpes virus-8 (HHV-8), a carcinogenic agent declared by the World Health Organization. Human genetic variability may account for the variability in the clinical outcome of HHV-8 infection. Dr. Jackson aims to discover novel genetic alterations underlying childhood KS and to understand how specific gene defects drive KS in conjunction with HHV-8.