Damon Runyon Researchers

Meet Our Scientists
Abigail E. Overacre-Delgoffe, PhD

Dr. Overacre-Delgoffe is utilizing unique tools to address how the interaction between the host’s immune system and gut microbes affects colon tumor progression and patient responsiveness to current immunotherapies. Currently, colon cancer patients show an extremely limited response to immune-based therapies and have very poor survival rates. The colon is a unique environment that is composed of host cells and numerous bacteria and microbes that have evolved with the host. Dr. Overacre-Delgoffe aims to understand the basic mechanisms of immunotherapy resistance due to microbiome-immune system interactions, which may aid in developing more effective therapeutics for colon cancer.

Project title: "Microbiome control of the tumor microenvironment: harnessing immunosuppression and exhaustion"
Institution: University of Pittsburgh
Award Program: Fellow
Sponsor(s) / Mentor(s): Timothy W. Hand, PhD, and Olivera J. Finn, PhD
Cancer Type: Colorectal
Research Area: Tumor Immunology