Andrew A. Bridges, PhD

Dr. Bridges studies how bacterial cells form communities called biofilms that have particular three-dimensional architectures. He is investigating how the bacterial cell-cell communication process called quorum sensing drives the spatio-temporal gene expression patterns that govern biofilm formation. Biofilm bacteria are implicated as causal in various cancers and, furthermore, cancer patients receiving chemotherapy frequently suffer from infections caused by bacteria that rely fundamentally on biofilm formation for pathogenesis.

Antony J. Burton

Dr. Burton studies how chemical modification of histone proteins leads to changes in the structure of chromatin, the physiologically relevant form of DNA, and how misregulation of this higher-order assembly can lead to aberrant gene transcription patterns and cancer. He will use chemical biology tools to carry out precise chemistry in live cells, and determine direct causality in the downstream effects on DNA accessibility and transcription.

Ralph E. Kleiner, PhD

Many cancers result from an alteration in a cell's genetic material or DNA -- the basic instruction manual for life. Even a subtle change in DNA sequence can cause dramatic effects and reprogram normal cells, leading to cancer. While many cancers have genetic components, a more recent paradigm in cancer biology has been the study of cellular reprogramming founded in epigenetic or epitranscriptomic changes, which occur without alteration of the underlying DNA sequence. Dr.