Dr. Lin [HHMI Fellow] is studying how small RNAs called miRNAs are specifically targeted for destruction in cells. Because miRNAs are key regulators of gene expression, both miRNA production and destruction must be controlled in an accurate and timely manner. Dysregulation of these processes contributes to cancer progression. Dr. Lin is developing biochemical and high-throughput sequencing approaches to uncover the rules governing miRNA destruction and how they change in cancer.
Damon Runyon Researchers
Meet Our Scientists
Daniel H. Lin, PhD
Project title: "The influence of RNA and protein conformation on target-directed miRNA degradation"
Institution: Whitehead Institute for Biomedical Research
Named Award: HHMI Fellow
Award Program: Fellow
Sponsor(s) / Mentor(s): David P. Bartel, PhD
Cancer Type: All Cancers
Research Area: RNA (RNA processing, miRNA and piRNA mechanisms, enzymatic RNAs, etc.)
