Current and Former Awardees

Clinical Investigators

2017 Recipients

Vinod P. Balachandran, MD
Defining the evolutionary dynamics and antigen potential of neoantigens for human pancreatic cancer immunotherapy at Memorial Sloan Kettering Cancer Center
Adrienne A. Boire, MD, PhD
Molecular determinants of leptomeningeal metastasis: a translational approach at Memorial Sloan Kettering Cancer Center
Gavin P. Dunn, MD, PhD
Characterizing the immunogenic landscape of glioblastoma at Washington University
Piro Lito, MD, PhD
Modeling the evolution of resistance to ERK signaling inhibitors at the single cell level at Memorial Sloan Kettering Cancer Center
Mark G. Shrime MD, MPH, PhD
Cash transfers for cancer surgery in West Africa: their health and economic consequences at Massachusetts Eye and Ear Infirmary

2016 Recipients

Vivek K. Arora, MD, PhD
"Defining a targetable oncogenic dyad in bladder cancer" at Washington University
Christopher E. Barbieri, MD, PhD
"Presurgical trials to target distinct subclasses of localized prostate cancer" at Weill Cornell Medicine
Ami S. Bhatt, MD, PhD
"Applying microbiome-based therapeutics in cancer patients" at Stanford University
Jaehyuk Choi, MD, PhD
"Identification of genetic basis of altered T cell receptor signaling in cutaneous T cell lymphoma" at Northwestern University
Alex Kentsis, MD, PhD
"Mechanism and function of regulatory signaling in acute myeloid leukemia" at Memorial Sloan Kettering Cancer Center
Geoffrey R. Oxnard, MD
"Noninvasive genotyping of cell free plasma DNA (cfDNA) as a tool for guiding personalized lung cancer care" at Dana-Farber Cancer Institute
Heather L. Yeo, MD
"Use of mobile applications to evaluate post surgical recovery in aging patients with GI cancer" at Weill Cornell Medicine

2015 Recipients

Priscilla K. Brastianos, MD
"Investigation of novel targeted therapeutic approaches for brain metastases" at Massachusetts General Hospital
Aude G. Chapuis, MD
"To specify the requirements of CD8+ and CD4+ T cells for successful adoptive transfer in solid tumors" at Fred Hutchinson Cancer Research Center
Marco L. Davila MD, PhD
"The development and clinical translation of an armored CAR T cell therapy for immune-resistant B cell malignancies" at H. Lee Moffitt Cancer Center
Eliezer M. Van Allen, MD
"Dissecting response to conventional and emerging DNA damage and repair therapies" at Dana-Farber Cancer Institute

2014 Recipients

Arash Ash Alizadeh, MD, PhD
"Targeting the malignant reprograming of early hematopoietic progenitors to mature aggressive human B-cell lymphomas" at Stanford University School of Medicine
Joshua Brody, MD
"Flt3L-primed 'in situ' vaccination for low-grade lymphoma - Phase I/II study of intratumoral injection of rhuFlt3L and poly-ICLC with low-dose radiotherapy [NCT01976585]" at Mt. Sinai Hospital
L. Elizabeth Budde, MD, PhD
"Targeting CD123 using chimeric antigen receptor T cells for treatment of acute myeloid leukemia" at City of Hope
Alejandro Gutierrez, MD
"Mechanisms and therapeutic targeting of EZH2-dependent chemoresistance in T-ALL" at Boston Children's Hospital
Peter S. Hammerman, MD, PhD
"Development of personalized cancer immunotherapy" at Dana-Farber Cancer Institute
Luc G. Morris, MD
"Functionalizing tumor suppressor gene mutations and deletions in head and neck cancer" at Memorial Sloan Kettering Cancer Center
Stephen Oh, MD, PhD
"Targeting aberrant signaling pathways in myeloproliferative neoplasms" at Washington University

2013 Recipients

Omar Abdel-Wahab, MD
"Understanding and targeting altered histone modifiers in the myeloid malignancies" at Memorial Sloan Kettering Cancer Center
Himisha Beltran, MD
"Utilizing genome sequencing to elucidate mechanisms of resistance in advanced prostate cancer" at Weill Medical College of Cornell University
Christine M. Lovly, MD, PhD
"Developing novel therapeutic strategies for ALK-fusion positive lung cancer" at Vanderbilt University
Ann Mullally, MD
"Determining the role of aberrant growth factor signaling in maintaining disease-propagating cells and mediating JAK2 inhibitor resistance in myeloproliferative neoplasms" at Brigham and Women's Hospital
Deepak Nijhawan, MD, PhD
"Using chemistry to identify new targets in lung cancer" at University of Texas Southwestern Medical Center
Cameron J. Turtle, MD, PhD
"The impact of the colonic microbiota on reconstitution of CD161hi cells and clinical outcomes after allogeneic hematopoietic stem cell transplantation" at Fred Hutchinson Cancer Research Center

2012 Recipients

Carey K. Anders, MD
"mTOR inhibition in the treatment of HER2-positive breast cancer brain metastases" at University of North Carolina, Chapel Hill
Oren J. Becher, MD
"Regional differences in central nervous system gliomagenesis" at Northwestern University
Sarat Chandarlapaty, MD, PhD
"Therapeutic approaches to PI3K-AKT-mTOR feedback pathways in breast cancer" at Memorial Sloan Kettering Cancer Center
Ryan B. Corcoran, MD, PhD
"Defining novel targeted therapy combination strategies for BRAF V600 mutant colorectal cancer" at Massachusetts General Hospital
Kevin B. Jones, MD
"The mitochondrial apoptosis pathway in synovial sarcoma" at University of Utah, Salt Lake City
Holbrook E. Kohrt, MD, PhD
"Augmenting anticancer antibody therapies through selective activation of NK cells" at Stanford University

2011 Recipients

Marie Bleakley, MD, PhD
"Segregating the GVL effect from GVHD in humans" at Fred Hutchinson Cancer Research Center
Ralph J. DeBerardinis, MD, PhD
"Translational studies in cancer metabolism" at University of Texas Southwestern Medical Center
Joshua D. Schiffman, MD
"Microsatellite length and integrin signaling as risk factors for Ewing's Sarcoma" at University of Utah, Salt Lake City
Zsofia K. Stadler, MD
"Genomic assessment of de novo germline cancer susceptibility in pediatric malignancies" at Memorial Sloan Kettering Cancer Center
Jean Y. Tang, MD, PhD
"Mechanisms of acquired resistance to Hedgehog pathway inhibitors in basal cell carcinomas" at Stanford University

2010 Recipients

Tobias J.E. Carling, MD, PhD
"Molecular genetics of endocrine tumor disease" at Yale University School of Medicine
N. Lynn Henry, MD, PhD
"Pain processing pathway analysis in aromatase inhibitor-associated musculoskeletal syndrome" at University of Michigan, Ann Arbor
Kevin R. Kozak, MD, PhD
"Radiosensitization with antiangiogenic therapy" at University of Wisconsin, Madison
Igor Matushansky, MD, PhD
"Implementing and imaging epigenetic based differentiation therapy for solid tumors" at Columbia University
Brian G. Till, MD
"Optimization of adoptive immunotherapy for lymphoma using genetically modified CD20-specific T cells" at Fred Hutchinson Cancer Research Center

2009 Recipients

Andrew L. Feldman, MD
"Role of novel TP63 fusion genes in IRF4-positive peripheral T-cell lymphoma" at Mayo Clinic
William Y. Kim, MD
"Defining synthetic lethal targets of mTOR inhibition in renal cell carcinoma" at University of North Carolina, Chapel Hill
C. Ryan Miller, MD, PhD
"Genomics-driven drug development for glioblastoma" at University of North Carolina, Chapel Hill
Vu H. Nguyen, MD
"Organ-specific regulatory T cells as a targeted therapy for graft-versus-host disease" at The University of Chicago

2008 Recipients

Ronald J. Buckanovich, MD, PhD
"Tumor endothelial cells as a therapeutic and diagnostic target in ovarian cancer" at University of Michigan, Ann Arbor
Andrew T. Chan, MD, MPH
"Molecular imaging of colorectal neoplasia" at Massachusetts General Hospital
Rachael A. Clark, MD, PhD
"Reversing immune evasion in human squamous cell carcinomas of the skin" at Brigham and Women's Hospital
Vassiliki Karantza, MD, PhD
"Autophagy as a therapeutic target in breast cancer treatment" at UMDNJ/Robert Wood Johnson Medical School
Elahe A. Mostaghel, MD, PhD
"Defining and exploiting molecular mechanisms of androgen-metabolism for prostate cancer therapy" at Fred Hutchinson Cancer Research Center

2007 Recipients

Colleen Delaney, MD, MSc
“Notch-mediated ex vivo expansion of cord blood progenitors for hematopoietic cell transplantation” at Fred Hutchinson Cancer Research Center
Douglas K. Graham, MD, PhD
“Novel biologically targeted therapy against the Mer receptor tyrosine kinase in the treatment of pediatric ALL” at University of Colorado Denver
Juan Carlos Ramos, MD
“Resistance to interferon-based therapy in adult T-cell leukemia” at University of Miami School of Medicine
Joel H. Rubenstein, MD
"The epidemiology of adipokines in Barrett's esophagus” at University of Michigan Medical School
Catherine J. Wu, MD
“Immune-targeted leukemia antigens for eradication of CML stem cells” at Dana-Farber Cancer Institute

2006 Recipients

Renier J. Brentjens, MD, PhD
“Adoptive therapy of B cell leukemias with genetically modified autologous T cells” at Memorial Sloan Kettering Cancer Center
Patrick A. Brown, MD
“Translating FLT3 inhibition into improved outcome for high risk childhood leukemia” at Johns Hopkins University
Delphine L. Chen, MD
“Apoptosis imaging” at Washington University School of Medicine
Andrea L. Cox, MD, PhD
“Analysis and manipulation of cross reactive immune responses to partial escape mutations in chronic Hepatitis C virus infection” at Johns Hopkins University
Loren S. Michel, MD
“Characterization of the Trop-2 receptor in breast cancer progression” at Washington University School of Medicine

2005 Recipients

Marcia S. Brose, MD, PhD
"The emerging clinical role of genetics in the treatment and diagnosis of thyroid cancer" at University of Pennsylvania, Philadelphia
Christine H. Chung, MD
"Gene expression-based outcome prediction in head and neck cancer" at Vanderbilt University Medical Center
Phillip G. Febbo, MD
"Mechanisms of docetaxel resistance in metastatic prostate cancer" at Duke University Medical Center
John M. Pagel, MD, PhD
"Radioimmunotherapy of CD45+ leukemias" at Fred Hutchinson Cancer Research Center
John M. Timmerman, MD
"Dendritic cell-based outcome prediction in head and neck cancer" at University of California, Los Angeles

2004 Recipients

Charles G. Drake, MD, PhD
"Integrating clinical and laboratory studies to develop immunotherapy for prostate cancer" at Johns Hopkins University
Jakob Dupont, MD
"Development and analysis of tumor-specific T cells for adoptive immunotherapy of epithelial ovarian cancer" at Memorial Sloan Kettering Cancer Center
John V. Heymach, MD, PhD
"VEGF receptor inhibitors for non-small cell lung cancer: clinical studies and novel surrogate markers of activity" at M.D. Anderson Cancer Center
Jeremy N. Rich, MD
"Maximizing clinical efficacy of epidermal growth factor receptor tyrosine kinase inhibitors in glioblastoma therapy" at Cleveland Clinic Foundation

2003 Recipients

Scott A. Armstrong, MD, PhD
“Genomic identification of new therapeutic targets in leukemia” at Boston Children's Hospital
Peter D. Cole, MD
“Improving the therapeutic index for children with acute lymphoblastic leukemia through studies of folate physiology and antifolate pharmacodynamics” at Albert Einstein College of Medicine
Dean W. Felsher, MD, PhD
“Targeting MYC for the treatment of lymphoma” at Stanford University School of Medicine
Jedd D. Wolchok, MD, PhD
“Clinical development of DNA vaccines for melanoma” at Memorial Sloan Kettering Cancer Center

2002 Recipients

Madhav V. Dhodapkar, MD
“Anti-tumor immunity in myeloma” at The Rockefeller University
William M. Grady, MD
“Novel molecular screening and surveillance methods for colorectal cancer” at Fred Hutchinson Cancer Research Center
Albert C. Koong, MD, PhD
“Modulation of protein kinase C as a novel hypoxia-specific therapeutic strategy” at Stanford University School of Medicine
Sridhar Mani, MD
“Molecular and phenotypic dose adaptation models in the clinical development of novel microtubule binding agents” at Albert Einstein College of Medicine
James M. Olson, MD, PhD
“Predicting retinoid-responsive medulloblastoma patients” at Fred Hutchinson Cancer Research Center

2001 Recipients

Joseph A. Califano, III, MD
“Molecular screening in a population at risk for head and neck cancer” at The Johns Hopkins University School of Medicine
Li Li, MD, PhD
“Diet, methylenetetrahydrofolate reductase, genomic DNA methylation, and five most promising novel candidate genes in the carcinogenesis of colon neoplasia” at Case Western Reserve University
Jennifer L. Malin, MD
“Quality of chemotherapy care for cancer: evaluating underuse, overuse and misuse” at University of California, Los Angeles
William R. Sellers, MD
“The molecular classification of prostate cancer” at Dana-Farber Cancer Institute
Cassian Yee, MD
“Adoptive T-cell therapy of melanoma” at Fred Hutchinson Cancer Research Center

2000 Recipients

Rafael Fonseca, MD
“Genomic instability in plasma cell dyscrasias” at Mayo Clinic, Scottsdale
Maura L. Gillison, MD, PhD
“Establishing a casual association between HPV and HNSCC” at The Johns Hopkins University School of Medicine
Vered Stearns, MD
“Surrogate markers as endpoints: novel clinical design for combining standard and novel therapies in breast cancer” at The Johns Hopkins University School of Medicine
Robert H. Vonderheide, MD, PhD
“Clinical evaluation of telomerase as a widely expressed tumor-associated antigen linked to oncogenesis” at University of Pennsylvania, Philadelphia
Edus “Hootie” Warren, MD, PhD
“Antigen-specific T-cell therapy for leukemia” at Fred Hutchinson Cancer Research Center
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