Select a highlighted state to learn more about the scientists
and projects that Damon Runyon is currently funding.
Scientists by State
City of Hope
L. Elizabeth Budde, MD, PhD
"Targeting CD123 using chimeric antigen receptor T cells for treatment of acute myeloid leukemia"
with Stephen J. Forman, MD, FACP
Stanford University
Ami S. Bhatt, MD, PhD
"Applying microbiome-based therapeutics in cancer patients"
with Linda Boxer, MD, PhD, and Michael Snyder, PhD
Christopher J. Cambier, PhD
"In vivo characterization of mycobacterial cording"
with Carolyn Bertozzi, PhD
Jennifer L. Caswell-Jin, MD
"Breast cancer evolution and resistance in response to HER2-targeted therapy"
with Christina N. Curtis, PhD, and Allison W. Kurian, MD
Ryan A. Flynn, MD, PhD
"The interplay between cellular metabolism and RNA homeostasis in disease"
with Carolyn R. Bertozzi, PhD
Victoria Hung, PhD
"Defining the post-translational landscape of ribosomes in control of gene regulation and cell fate"
with Maria Barna, PhD
John C. Janetzko, PhD
"A biophysical approach to studying GRK-GPCR complexes"
with Brian K. Kobilka, MD
David M. Kurtz, MD, PhD
"Response prediction and personalized therapy from mathematical modeling of circulating tumor DNA in non-Hodgkin lymphoma"
with Arash A. Alizadeh, MD, PhD
Kathrin Leppek, PhD
"Mechanistic characterization of 5’UTR RNA elements that confer translational specificity to shape vertebrate embryonic development"
with Maria Barna, PhD
Chuan Li, PhD
Quantifying epistasis among tumor suppressor genes and revealing the underlying expression profiles at the single-cell level
with Dmitri Petrov, PhD
Fangfei Qu, PhD
"Decoding the molecular and cellular mechanisms underlying the growth of brain metastases"
with Julien Sage, PhD
Jianjin Shi, PhD
"Biochemical and genetic dissection of axon degeneration"
with Marc Tessier-Lavigne, PhD
Shaogeng (Steven) Tang, PhD
"Toward small-molecule inhibitors against human immune checkpoint PD-1"
with Peter S. Kim, PhD
Kathryn R. Taylor, PhD
"The effect of neuronal activity on pediatric glioma invasion"
with Michelle L. Monje, MD, PhD
Albert G. Tsai, MD, PhD
"Diagnosis of hematologic malignancies from paucicellular aspirate material using highly multiplexed single cell analysis"
with Sean Bendall, PhD
Jing Lin Xie, PhD
"Remembering the past: epigenetic mechanisms of cancer drug resistance"
with Daniel F. Jarosz, PhD
The Scripps Research Institute
Marsha M. Hirschi, PhD
Molecular engineering of an optically controlled glutamate receptor
with Gabriel C. Lander, PhD
University of California, Berkeley
Gina V. Caldas, PhD
"Analysis of CSR- function in C. elegans embryonic cell division"
with Abby F. Dernburg, PhD
Allison Didychuk, PhD
Viral mimics of host transcription factors in oncogenic herpesviruses
with Britt Glaunsinger, PhD
Stephanie Gates, PhD
Decoding the ubiquitin receptor recognition mechanism of the 26S proteasome
with Andreas Martin, PhD
Jamie Lahvic, PhD
Uncovering cell non-autonomous mechanisms of tumor suppression
with Iswar Hariharan, MMBS, PhD
Andrew C. Murley, PhD
"Cell non-autonomous communication of ER stress resistance"
with Andrew G. Dillin, PhD
University of California, San Francisco
Özlem Aksoy, PhD
"Understanding the role of translational control in humanized mouse models for medulloblastoma"
with Davide Ruggero, PhD
Collin M. Blakely, MD, PhD
"Mechanisms of incomplete response and primary resistance to osimertinib in EGFR-mutant lung cancer"
with Trever G. Bivona, MD, PhD
Vladislav Belyy, PhD
"Mapping the unfolded protein response signaling network with optogenetic actuators"
with Peter Walter, PhD
Julia C. Carnevale, MD
"Developing new therapeutic approaches for pancreatic cancer with homologous recombination repair defects"
with Alan Ashworth, PhD
Kyle G. Daniels, PhD
"Controlling T cell signaling and fate choice using synthetic receptors"
with Wendell Lim, PhD
Jeffrey A. Hussmann, PhD
"Genome-wide measurement of ribosome spacing on individual transcripts"
with Carol Gross, PhD
Brian J. Laidlaw, PhD
"Role of EBI2 in the regulation of lymphocyte migration during viral infection and cancer"
with Jason Cyster, PhD
Kara L. McKinley, PhD
"Mechanisms and functions of cellular rearrangements in epithelia"
with Ronald D. Vale, PhD
Lyndsay M. Murrow, PhD
"Fate specification of mammary stem cells by cell self-sorting"
with Zev J. Gartner, PhD
Trang Nguyen, PhD
Bypassing the unresponsiveness of T cell anergy and exhaustion
with Arthur Weiss, MD, PhD
Jessica Sheu-Gruttadauria, PhD
"Probing the dynamic organizational network of membraneless organelles through systems-level analysis and imaging"
with Ronald D. Vale, PhD
Sukrit Silas, PhD
"Discovery and characterization of virally-encoded translation factors"
with Jonathan S. Weissman, PhD, and Carol A. Gross, PhD
Digvijay Singh, PhD
"Cryo-electron tomography of phase-separated transcription factories in situ"
with Elizabeth Villa, PhD
Catherine C. Smith, MD
"Defining structure, function and therapeutic impact of oncogenic FLT3 mutations"
with Neil P. Shah, MD, PhD
Linda T. Vo, PhD
"Off-the-shelf T cells from human pluripotent stem cells with precise tumor recognition using combinatorial antigen-sensing circuits"
with Jeff A. Bluestone, PhD
Yichen Xu, PhD
"Elucidating a non-classical role of ER in gene expression and breast cancer progression"
with Davide Ruggero, PhD
Dian Yang, PhD
Dissecting intratumoral heterogeneity and hierarchy at single cell resolution
with Jonathan S. Weissman, PhD, and Trever G. Bivona, MD, PhD
Ziyang Zhang, PhD
"Controlling the activity of bispecific T cell engagers with a chemically cleavable molecular switch"
with Kevan M. Shokat, PhD
Yale University
Esen Sefik, PhD
"The effect of microbes, diet on the intestinal immune system in the context of obesity and cancer"
with Richard A. Flavell, PhD
The University of Chicago
Michael W. Drazer, MD
"Defining leukomogenic mechanisms in hereditary hematologic malignancies"
with Lucy A. Godley, MD, PhD
National Institutes of Health
Danfeng Cai, PhD
"Protein crowding and protein folding landscapes as predictors of healthy and diseased cell states"
with Jennifer Lippincott-Schwartz, PhD
The Johns Hopkins University
Daniel H. Goldman, PhD
"Elucidating the role of the exon junction complex in regulating translation of spliced mRNA"
with Rachel Green, PhD
Michael A. Koldobskiy, MD, PhD
"DNA methylation stochasticity in pediatric pre-B cell acute lymphoblastic leukemia"
with Andrew P. Feinberg, MD
The Johns Hopkins University School of Medicine
Challice L. Bonifant, MD, PhD
"Dual-antigen targeting by ENG-T cells as improved anti-AML therapy"
with Donald Small, MD, PhD
Xintong Dong, PhD
"Investigating ligand-receptor interactions between defensins and mrgprs in cutaneous inflammation and wound healing"
with Xinzhong Dong, PhD
Evan J. Worden, PhD
"The mechanistic basis of crosstalk between histone H2B ubiquitylation and H3K79 methylation"
with Cynthia Wolberger, PhD
Boston Children's Hospital
Megan Insco, MD, PhD
"Investigating transcriptional cyclin dependent kinases as novel melanoma drug targets"
with Len Zon, MD
Yuxiang Zhang, PhD
Mechanisms that promote DNA double strand break clusters in brain and liver
with Frederick W. Alt, PhD
Dana-Farber Cancer Institute
Pavan Bachireddy, MD
"Coevolution of tumor and T cell heterogeneity following immunotherapy"
with Catherine J. Wu, MD
Giada Bianchi, MD
"Molecular mechanisms of ROBO1 in multiple myeloma pathogenesis"
with Kenneth C. Anderson, MD
Phillip A. Dumesic, MD, PhD
"Identification of muscle-secreted factors responsible for local and systemic effects of exercise"
with Bruce M. Spiegelman, PhD
Adam D. Durbin, MD, PhD
Interrogation of neuroblastoma dependencies and non-coding RNAs on the core-regulatory circuitry for therapeutic inhibition
with A. Thomas Look, MD
Eric S. Fischer, PhD
"Novel mechanisms for small molecule induced targeted degradation of RRM family proteins"
Christopher J. Gibson, MD
"Elucidating the connection between clonal hematopoiesis and lymphoma in humans"
with Benjamin L. Ebert, MD, PhD
Lillian M. Guenther, MD
"Investigation of CITED2 as a novel dependency in Ewing sarcoma"
with Kimberly Stegmaier, MD
Tikvah K. Hayes, PhD
"Systematic genomic and functional analysis of small cell lung cancer"
with Matthew L. Meyerson, MD, PhD
Whitney Johnson, PhD
Using organoid cancer models to identify genome catastrophe mechanisms
with David Pellman, MD
Loretta S. Li, MD
"Mechanisms of disease and resistance in CRLF2-rearranged B-cell acute lymphoblastic leukemia"
with David M. Weinstock, MD
Joseph D. Mancias, MD, PhD
“Identifying the pancreatic tumor MHC-I ligandome in response to ionizing radiation for combination radiation-immunotherapy”
Sarah Naomi Olsen, PhD
Targeted degradation of the MLL-AF9 fusion oncoprotein in acute myeloid leukemia
with Scott A. Armstrong, MD, PhD
Geoffrey R. Oxnard, MD
"Noninvasive genotyping of plasma cell-free DNA (cfDNA) as a tool for guiding personalized lung cancer care"
with Pasi A. Janne, MD, PhD
Harshabad Singh, MBBS
"Cellular origins of Barrett’s esophagus and its role in development of adenocarcinoma"
with Ramesh A. Shivdasani, MD, PhD
Neil T. Umbreit, PhD
"Elucidating the mechanism of chromosome bridge resolution"
with David S. Pellman, MD
Eliezer M. Van Allen, MD
"Dissecting response to conventional and emerging DNA damage and repair therapies"
with Geoffrey I. Shapiro, MD, PhD
Harvard Medical School
Justin A. Bosch, PhD
"Characterizing novel molecules and mechanisms that mediate cell-cell communication"
with Norbert Perrimon, PhD
Amelia N. Chang, PhD
"The role of activity-regulated gene expression in human brain evolution"
with Michael E. Greenberg, PhD
Anne E. Dodson, PhD
"Transgenerational inheritance of structure-based infections"
with Scott G. Kennedy, PhD
Ivana Gasic, Dr.Sc.
"Molecular elucidation of the interphase microtubule integrity response (MIR)"
with Timothy Mitchison, PhD
Lucy Liu, PhD
"The fat-brain axis: identifying the roles of adipokine signaling in nervous system function"
with Norbert Perrimon, PhD
Nagarajan Nandagopal, PhD
Signal integration by bHLH circuits to enable cell fate decisions
with Galit Lahav, PhD, and Sean Megason, PhD
Natasha M. O'Brown, PhD
"Molecular and cellular mechanisms of transcytosis regulation in blood-brain barrier function"
with Chenghua Gu, PhD
Sarah J. Pfau, PhD
"Investigating the molecular determinants of blood-brain barrier heterogeneity"
with Chenghua Gu, PhD
Maxim Pimkin, MD, PhD
Divergent core transcriptional circuitries highlight context-specific vulnerabilities in AML
with Stuart Orkin, MD
Deepshika Ramanan, PhD
"Identifying functions of regulatory T cell subsets in intestinal inflammation and colorectal cancer"
with Christophe Benoist, MD, PhD
Justin L. Sparks, PhD
"Replicative helicase bypass of bulky DNA adducts?"
with Johannes C. Walter, PhD
Benjamin M. Stinson, PhD
"Mechanism of DNA processing during non-homologous end joining"
with Johannes C. Walter, PhD, and Joseph L. Loparo, PhD
Jonathan G. Van Vranken
"Systematic identification of metabolite-protein interactions in human cells"
with Steven Gygi
Harvard University
Philip B. Abitua, PhD
"Developmental mechanisms of killifish cell dispersion and aggregation"
with Alexander Schier, PhD
Monica E. McCallum, PhD
"Understanding alanosine biosynthesis to discover new cancer chemotherapeutics"
with Emily P. Balskus, PhD
Koch Institute for Biomedical Research
Alexander Jaeger, PhD
"Surveying the chromatin architecture shaped by HSF1 in cancer"
with Tyler E. Jacks, PhD
Massachusetts General Hospital
Priscilla K. Brastianos, MD
"Investigation of novel targeted therapeutic approaches for brain metastases"
with Keith T. Flaherty, MD and Tracy T. Batchelor, MD
Jan P. Schuemann, PhD
“Using extreme dose rates to protect healthy tissue in proton radiation therapy”
Iva Tchasovnikarova, PhD
"Deciphering the role of chromatin remodeling in epigenetic repression by the HUSH complex"
with Robert Kingston, PhD
Kurt J. Warnhoff, PhD
"Molybdenum cofactor biosynthetic enzymes modulate miRNA biology and development"
with Gary B. Ruvkun, PhD
Massachusetts Institute of Technology
Lindsay M. LaFave, PhD
"Investigating epigenetic mechanisms of transformation in SWI/SNF-mutant non-small cell lung cancer"
with Tyler Jacks, PhD
Jose M. Ordovas-Montanes, PhD
"Single-cell genomic approaches for tracing the contribution of inflammation to human colon cancer"
with Alex Shalek, PhD
Sharanya Sivanand, PhD
"Understanding metabolic heterogeneity in primary and metastatic tumors"
with Matthew G. Vander Heiden, MD, PhD
Whitehead Institute for Biomedical Research
Laura Blanton, PhD
"The impact of sex chromosome constitution on immune cell gene expression and function"
with David C. Page, MD
Elizabeth Costa, PhD
"Exploring the cell adhesion landscape through host-pathogen interactions"
with Sebastian Lourido, PhD
Nora Kory, PhD
"Identifying new components of mitochondrial one-carbon metabolism"
with David M. Sabatini, MD, PhD
Daniel H. Lin, PhD
Global influence of mRNA conformation on eukaryotic translational regulation
with David P. Bartel, PhD
Alexandra Nguyen, PhD
"Defining the cell type specific cell division requirements in acute myeloid leukemias"
with Iain M. Cheeseman, PhD
Princeton University
Andrew A. Bridges, PhD
"Bacterial cell fates: The role of quorum sensing in biofilm patterning"
with Bonnie L. Bassler, PhD
Columbia University
J. Brooks Crickard, PhD
"Visualizing the strand invasion during homologous recombination on the single molecule level"
with Eric C. Greene, PhD
Icahn School of Medicine at Mount Sinai
Joshua Brody, MD
"Flt3L-primed 'in situ' vaccination for low-grade lymphoma - Phase I/II study of intratumoral injection of rhuFlt3L and poly-ICLC with low-dose radiotherapy [NCT01976585]"
with Nina Bhardwaj, MD, PhD and Miriam Merad, MD, PhD
Memorial Sloan Kettering Cancer Center
Vinod P. Balachandran, MD
"Defining the evolutionary dynamics and antigen potential of neoantigens for human pancreatic cancer immunotherapy"
with Steven D. Leach, MD, and Jedd D. Wolchok, MD, PhD
Harihar Basnet, PhD
"Identifying determinants of latency in brain metastatic breast cancer cells"
with Joan Massague, PhD
Adrienne A. Boire, MD, PhD
"Molecular determinants of leptomeningeal metastasis: a translational approach"
with Joan Massagué, PhD
Robert L. Bowman, PhD
"Interrogating the subclonal architecture and functional contributions of mutation order in FLT3-ITD mutant AML"
Matthew D. Hellmann, MD
"Defining intratumoral and peripheral mechanisms mediating initiation of response, durability, and resistance to PD-1 blockade to inform rational immunotherapeutic development in NSCLC"
with Charles M. Rudin, MD, PhD, and Jedd D. Wolchok, MD, PhD
Andrew M. Intlekofer, MD, PhD
"Metabolic coupling of the hypoxic niche to stemness"
with Ross L. Levine, MD
Alex Kentsis, MD, PhD
"Mechanism and function of regulatory signaling in acute myeloid leukemia"
with Scott A. Armstrong, MD, PhD, and Ross L. Levine, MD
Bryan C. King, PhD
"AMPK-induced catabolism of extracellular proteins: a novel survival mechanism for nutrient-deprived cancer cells"
with Craig B. Thompson, MD
Christopher A. Klebanoff, MD
"Clinical development of next-generation T cell receptor (TCR)-based adoptive immunotherapies for the treatment of patients with common epithelial malignancies"
with Michel Sadelain, MD, PhD, and Larry Norton, MD
Piro Lito, MD, PhD
"Modeling the evolution of resistance to ERK signaling inhibitors at the single cell level"
with Neal X. Rosen, MD, PhD, and Charles M. Rudin, MD, PhD
New York University School of Medicine
Robert S. Banh, PhD
Metabolic contribution of sensory neurons to pancreatic tumorigenesis and serine metabolism, via peripheral axons
with Alec C. Kimmelman, MD, PhD, and Michael Pacold, MD, PhD
Lacy J. Barton, PhD
"Mechanisms of directed cell migration in a complex in vivo environment"
with Ruth Lehmann, PhD
June-Yong Lee, PhD
"Investigation of potential roles of serum amyloid A in peripheral Th17 cell pathogenicity"
with Dan R. Littman, MD, PhD
Stony Brook University
Benjamin L. Martin, PhD
"Cell cycle regulation of cellular behaviors associated with cancer metastasis"
The Rockefeller University
Aleksey Chudnovskiy, PhD
"Defining dendritic cell-T cell interaction history within the tumor microenvironment using enzymatic labeling"
with Gabriel D. Victora, PhD
Gregory P. Donaldson, PhD
"Cross-talk between B lymphocytes and bacteria in the maintenance of a non-inflammatory mucosal microbiome"
with Daniel Mucida, PhD
Yusong R. Guo, PhD
"Structural and mechanistic characterization of mechanosensitive Piezo channels"
with Roderick MacKinnon, MD
Yadira M. Soto-Feliciano, PhD
"Dissecting the role of Menin in acute leukemia"
with C. David Allis, PhD
Weill Cornell Medicine
Christopher E. Barbieri, MD, PhD
"Presurgical trials to target distinct subclasses of localized prostate cancer"
with Lewis C. Cantley, PhD
John R. Ferrarone, MD
"Seeking and evaluating novel therapeutic targets in human lung adenocarcinomas with loss-of-function mutations in LKB1"
with Harold E. Varmus, MD
Eric E. Gardner, PharmD, PhD
Interrogating lung adenocarcinoma transformation to small cell lung cancer at single cell resolution
with Harold E. Varmus, MD
Duke University
Lawrence A. David, PhD
"Personalized prebiotics to optimize microbiota metabolism and improve transplant outcomes"
Nicholas C. DeVito, MD
"Investigating the role of EMT-mediated dendritic cell tolerization in checkpoint inhibitor resistance"
with Brent A. Hanks, MD, PhD
University of Pennsylvania, Philadelphia
Brian C. Capell, MD, PhD
"Defining the role of epigenetic enhancer dysfunction in epithelial carcinogenesis"
with Shelley L. Berger, PhD
Geoffrey P. Dann, PhD
Proteomics to bridge protein arginylation, chromatin, and cancer
with Benjamin A. Garcia, PhD
University of Texas Southwestern Medical Center
Lindsay B. Case, PhD
"Regulation of integrin clustering on supported lipid bilayers"
with Michael Rosen, PhD
Elise C. Jeffery, PhD
"Characterizing a new hematopoietic stem cell niche factor"
with Sean Morrison, PhD
Fred Hutchinson Cancer Research Center
Aude G. Chapuis, MD
"Multifaceted transgenic TCR approach to high-risk AML"
with Philip D. Greenberg, MD
Alistair B. Russell, PhD
"Impact of heterogeneity on the cellular recognition of influenza infection"
with Jesse D. Bloom, PhD
Jay F. Sarthy, MD, PhD
Characterization of the epigenomic landscape of diffuse midline gliomas
with Steven Henikoff, PhD
University of Washington
Brian J. Beliveau, PhD
"Decoding Polycomb-mediated gene regulation in single cells with single-molecule super resolution imaging and synthetic biology"
Washington University
Vivek K. Arora, MD, PhD
"Defining a targetable oncogenic dyad in bladder cancer"
with Lee Ratner, MD, PhD
Gavin P. Dunn, MD, PhD
"Characterizing the immunogenic landscape of glioblastoma"
with John F. DiPersio, MD, PhD, and Robert D. Schreiber, PhD
Stephen T. Oh, MD, PhD
"Leveraging NFkB pathway dysregulation for therapeutic benefit in myeloproliferative neoplasms"
with Daniel C. Link, MD
