Select a highlighted state to learn more about the scientists
and projects that Damon Runyon is currently funding.
Scientists by State
City of Hope
L. Elizabeth Budde, MD, PhD
"Targeting CD123 using chimeric antigen receptor T cells for treatment of acute myeloid leukemia"
with Stephen J. Forman, MD, FACP
Stanford University
Ami S. Bhatt, MD, PhD
"Applying microbiome-based therapeutics in cancer patients"
with Linda Boxer, MD, PhD, and Michael Snyder, PhD
Alistair N. Boettiger, PhD
"Using super-resolution imaging to probe molecular mechanisms of Polycomb silencing"
Christopher J. Cambier, PhD
"In vivo characterization of mycobacterial cording"
with Carolyn Bertozzi, PhD
Jennifer L. Caswell-Jin, MD
"Breast cancer evolution and resistance in response to HER2-targeted therapy"
with Christina N. Curtis, PhD, and Allison W. Kurian, MD, MSc
Ryan A. Flynn, MD, PhD
"The interplay between cellular metabolism and RNA homeostasis in disease"
with Carolyn R. Bertozzi, PhD
Victoria Hung, PhD
"Defining the post-translational landscape of ribosomes in control of gene regulation and cell fate"
with Maria Barna, PhD
John C. Janetzko, PhD
"A biophysical approach to studying GRK-GPCR complexes"
with Brian K. Kobilka, MD
David M. Kurtz, MD, PhD
"Response prediction and personalized therapy from mathematical modeling of circulating tumor DNA in non-Hodgkin lymphoma"
with Arash A. Alizadeh, MD, PhD
Kathrin Leppek, PhD
"Mechanistic characterization of 5’UTR RNA elements that confer translational specificity to shape vertebrate embryonic development"
with Maria Barna, PhD
Fangfei Qu, PhD
"Decoding the molecular and cellular mechanisms underlying the growth of brain metastases"
with Julien Sage, PhD
Jianjin Shi, PhD
"Biochemical and genetic dissection of axon degeneration"
with Marc Tessier-Lavigne, PhD
Shaogeng (Steven) Tang, PhD
"Toward small-molecule inhibitors against human immune checkpoint PD-1"
with Peter S. Kim, PhD
Kathryn R. Taylor, PhD
"The effect of neuronal activity on pediatric glioma invasion"
with Michelle L. Monje, MD, PhD
Albert G. Tsai, MD, PhD
"Diagnosis of hematologic malignancies from paucicellular aspirate material using highly multiplexed single cell analysis"
with Sean Bendall, PhD
Jing Lin Xie, PhD
"Remembering the past: epigenetic mechanisms of cancer drug resistance"
with Daniel F. Jarosz, PhD
Stanford University School of Medicine
Anupam K. Chakravarty, PhD
"Investigating the phenomenon of epigenetic inheritance mediated by non-amyloid protein aggregates"
with Daniel F. Jarosz, PhD
Keren I. Hilgendorf, PhD
"Role of ciliary IGF-1/AKT signaling in ciliogenesis, adipogenesis, and tissue regeneration"
with Peter K. Jackson, PhD
The Salk Institute for Biological Studies
Corina E. Antal, PhD
"Stromal reprogramming as a therapeutic approach in pancreatic cancer"
with Ronald M. Evans, PhD
University of California, Berkeley
Gina V. Caldas, PhD
"Analysis of CSR- function in C. elegans embryonic cell division"
with Abby F. Dernburg, PhD
Fuguo Jiang, PhD
"Molecular mechanisms of guide RNA: target dsDNA binding and PAM recognition by CRISPR-Cas9"
with Jennifer A. Doudna, PhD
Andrew C. Murley, PhD
"Cell non-autonomous communication of ER stress resistance"
with Andrew G. Dillin, PhD
Neel H. Shah, PhD
"Interrogating ZAP-70 substrate recognition using high-throughput mutant screening"
with John Kuriyan, PhD
University of California, Los Angeles
Magdalena E. Potok, PhD
"The relationship between epigenetic gene silencing, nuclear architecture, and genome stability"
with Steven E. Jacobsen, PhD
University of California, San Francisco
Özlem Aksoy, PhD
"Understanding the role of translational control in humanized mouse models for medulloblastoma"
with Davide Ruggero, PhD
Vladislav Belyy, PhD
"Mapping the unfolded protein response signaling network with optogenetic actuators"
with Peter Walter, PhD
Julia C. Carnevale, MD
"Developing new therapeutic approaches for pancreatic cancer with homologous recombination repair defects"
with Alan Ashworth, PhD
Kyle G. Daniels, PhD
"Controlling T cell signaling and fate choice using synthetic receptors"
with Wendell Lim, PhD
Jeffrey A. Hussmann, PhD
"Genome-wide measurement of ribosome spacing on individual transcripts"
with Carol Gross, PhD
Brian J. Laidlaw, PhD
"Role of EBI2 in the regulation of lymphocyte migration during viral infection and cancer"
with Jason Cyster, PhD
Kara L. McKinley, PhD
"Mechanisms and functions of cellular rearrangements in epithelia"
with Ronald D. Vale, PhD
Lyndsay M. Murrow, PhD
"Fate specification of mammary stem cells by cell self-sorting"
with Zev J. Gartner, PhD
Duy P. Nguyen, PhD
"Genome editing via an engineered RNA-guided nuclease to create cancer genetic models"
with James A. Wells, PhD
Thomas M. Norman, PhD
"Identifying the stochastic determinants of drug resistance"
with Jonathan S. Weissman, PhD
Linda T. Vo, PhD
"Off-the-shelf T cells from human pluripotent stem cells with precise tumor recognition using combinatorial antigen-sensing circuits"
with Jeff A. Bluestone, PhD
Andrew L. Wolfe, PhD
"The therapeutic potential and biological effects of targeting oncogenic KRAS"
with Frank McCormick, PhD
Yichen Xu, PhD
"Elucidating a non-classical role of ER in gene expression and breast cancer progression"
with Davide Ruggero, PhD
Ziyang Zhang, PhD
"Controlling the activity of bispecific T cell engagers with a chemically cleavable molecular switch"
with Kevan M. Shokat, PhD
Yale University
Esen Sefik, PhD
"The effect of microbes, diet on the intestinal immune system in the context of obesity and cancer"
with Richard A. Flavell, PhD
The University of Chicago
Michael W. Drazer, MD
"Defining leukomogenic mechanisms in hereditary hematologic malignancies"
with Lucy A. Godley, MD, PhD
John D. Leonard, PhD
"Self-antigen recognition by regulatory T cells"
with Erin Adams, PhD, and Peter Savage, PhD
University of Illinois, Urbana-Champaign
Daniel J. Blair, PhD
"An automated small molecule synthesizer for the discovery of new anti-cancer agents"
with Martin D. Burke, MD, PhD
National Institutes of Health
Danfeng Cai, PhD
"Protein crowding and protein folding landscapes as predictors of healthy and diseased cell states"
with Jennifer Lippincott-Schwartz, PhD
The Johns Hopkins University
Stacy L. Cooper, MD
"The Cebpa +37kb enhancer is a critical target of transformation in acute myeloid leukemia"
with Alan D. Friedman, MD
Daniel H. Goldman, PhD
"Elucidating the role of the exon junction complex in regulating translation of spliced mRNA"
with Rachel Green, PhD
Michael A. Koldobskiy, MD, PhD
"DNA methylation stochasticity in pediatric pre-B cell acute lymphoblastic leukemia"
with Andrew P. Feinberg, MD
The Johns Hopkins University School of Medicine
Xintong Dong, PhD
"Investigating ligand-receptor interactions between defensins and mrgprs in cutaneous inflammation and wound healing"
with Xinzhong Dong, PhD
Evan J. Worden, PhD
"The mechanistic basis of crosstalk between histone H2B ubiquitylation and H3K79 methylation"
with Cynthia Wolberger, PhD
Brigham and Women's Hospital
Timothy D. Martin, PhD
"Investigating the role of aneuploidy and haploinsufficiency in driving tumorigenesis"
with Stephen J. Elledge, PhD
Ann Mullally, MD
"Determining the role of aberrant growth factor signaling in maintaining disease-propagating cells and mediating JAK2 inhibitor resistance in myeloproliferative neoplasms"
with Benjamin L. Ebert, MD, and Jerome Ritz, MD
Dana-Farber Cancer Institute
Pavan Bachireddy, MD
"Coevolution of tumor and T cell heterogeneity following immunotherapy"
with Catherine J. Wu, MD
Giada Bianchi, MD
"Molecular mechanisms of ROBO1 in multiple myeloma pathogenesis"
with Kenneth C. Anderson, MD
Phillip A. Dumesic, MD, PhD
"Identification of muscle-secreted factors responsible for local and systemic effects of exercise"
with Bruce M. Spiegelman, PhD
Eric S. Fischer, PhD
"Novel mechanisms for small molecule induced targeted degradation of RRM family proteins"
Christopher J. Gibson, MD
"Elucidating the connection between clonal hematopoiesis and lymphoma in humans"
with Benjamin L. Ebert, MD, DPhil
Tikvah K. Hayes, PhD
"Systematic genomic and functional analysis of small cell lung cancer"
with Matthew L. Meyerson, MD, PhD
Amanda Balboni Iniguez, PhD
"Targeting the EWS-FLI oncoprotein in Ewing sarcoma with CDK12/13 inhibitors"
with Kimberly Stegmaier, MD
Loretta S. Li, MD
"Mechanisms of disease and resistance in CRLF2-rearranged B-cell acute lymphoblastic leukemia"
with David M. Weinstock, MD
Geoffrey R. Oxnard, MD
"Noninvasive genotyping of cell-free plasma DNA (cfDNA) as a tool for guiding personalized lung cancer care"
with Pasi A. Janne, MD, PhD
Neil T. Umbreit, PhD
"Elucidating the mechanism of chromosome bridge resolution"
with David S. Pellman, MD
Eliezer M. Van Allen, MD
"Dissecting response to conventional and emerging DNA damage and repair therapies"
with Geoffrey I. Shapiro, MD, PhD
Eric Wang, PhD
"Enhancing anti-tumor immunity via pharmacological inhibition of kinases"
with Nathanael Gray, PhD
Harvard Medical School
Justin A. Bosch, PhD
"Characterizing novel molecules and mechanisms that mediate cell-cell communication"
with Norbert Perrimon, PhD
Anne E. Dodson, PhD
"Transgenerational inheritance of structure-based infections"
with Scott G. Kennedy, PhD
Ivana Gasic, Dr.Sc.
"Molecular elucidation of the interphase microtubule integrity response (MIR)"
with Timothy Mitchison, PhD
Lucy Liu, PhD
"In vivo characterization of muscle autophagy in health and disease"
with Norbert Perrimon, PhD
Natasha M. O'Brown, PhD
"Molecular and cellular mechanisms of transcytosis regulation in blood-brain barrier function"
with Chenghua Gu, PhD
Sarah J. Pfau, PhD
"Investigating the molecular determinants of blood-brain barrier heterogeneity"
with Chenghua Gu, PhD
Deepshika Ramanan, PhD
"Identifying functions of regulatory T cell subsets in intestinal inflammation and colorectal cancer"
with Christophe Benoist, MD, PhD
Justin L. Sparks, PhD
"Replicative helicase bypass of bulky DNA adducts?"
with Johannes C. Walter, PhD
Benjamin M. Stinson, PhD
"Mechanism of DNA processing during non-homologous end joining"
with Johannes C. Walter, PhD, and Joseph L. Loparo, PhD
Hume Akahori Stroud, PhD
"Understanding the mechanism and roles of changes in chromatin composition in the brain"
with Michael E. Greenberg, PhD
Thomas S. Vierbuchen, PhD
"Understanding the developmental programming and function of the enhancers that control activity-regulated transcription in the mammalian cortex"
with Michael E. Greenberg, PhD
Harvard T.H. Chan School of Public Health
Caitlin A. Brennan, PhD
"Mechanisms underlying Fusobacterium nucleatum-driven colorectal cancer"
with Wendy S. Garrett, MD, PhD
Harvard University
Philip B. Abitua, PhD
"Developmental mechanisms of killifish cell dispersion and aggregation"
with Alexander Schier, PhD
Monica E. McCallum, PhD
"Understanding alanosine biosynthesis to discover new cancer chemotherapeutics"
with Emily P. Balskus, PhD
Koch Institute for Biomedical Research
Alexander Jaeger, PhD
"Surveying the chromatin architecture shaped by HSF1 in cancer"
with Tyler E. Jacks, PhD
Massachusetts General Hospital
Priscilla K. Brastianos, MD
"Investigation of novel targeted therapeutic approaches for brain metastases"
with Keith T. Flaherty, MD and Tracy T. Batchelor, MD
Iva Tchasovnikarova, PhD
"Deciphering the role of chromatin remodeling in epigenetic repression by the HUSH complex"
with Robert Kingston, PhD
Massachusetts Institute of Technology
Lindsay M. LaFave, PhD
"Investigating epigenetic mechanisms of transformation in SWI/SNF-mutant non-small cell lung cancer"
with Tyler Jacks, PhD
Allison N. Lau, PhD
"Understanding metabolic heterogeneity in pancreatic cancer"
with Matthew G. Vander Heiden, MD, PhD
Jose M. Ordovas-Montanes, PhD
"Single-cell genomic approaches for tracing the contribution of inflammation to human colon cancer"
with Alex Shalek, PhD
Whitehead Institute for Biomedical Research
Laura Blanton, PhD
"The impact of sex chromosome constitution on immune cell gene expression and function"
with David C. Page, MD
Nora Kory, PhD
"Identifying new components of mitochondrial one-carbon metabolism"
with David M. Sabatini, MD, PhD
Princeton University
Andrew A. Bridges, PhD
"Bacterial cell fates: The role of quorum sensing in biofilm patterning"
with Bonnie L. Bassler, PhD
Columbia University
J. Brooks Crickard, PhD
"Visualizing the strand invasion during homologous recombination on the single molecule level"
with Eric C. Greene, PhD
Piero D. Dalerba, MD
"Using 'single-cell genomics' to resolve the molecular identity of 'cancer stem cells,' and guide their pharmacological eradication"
Icahn School of Medicine at Mount Sinai
Joshua Brody, MD
"Flt3L-primed 'in situ' vaccination for low-grade lymphoma - Phase I/II study of intratumoral injection of rhuFlt3L and poly-ICLC with low-dose radiotherapy [NCT01976585]"
with Nina Bhardwaj, MD, PhD and Miriam Merad, MD, PhD
Memorial Sloan Kettering Cancer Center
Vinod P. Balachandran, MD
"Defining the evolutionary dynamics and antigen potential of neoantigens for human pancreatic cancer immunotherapy"
with Steven D. Leach, MD, and Jedd D. Wolchok, MD, PhD
Harihar Basnet, PhD
"Identifying determinants of latency in brain metastatic breast cancer cells"
with Joan Massague, PhD
Adrienne A. Boire, MD, PhD
"Molecular determinants of leptomeningeal metastasis: a translational approach"
with Joan Massagué, PhD
Robert L. Bowman, PhD
"Interrogating the subclonal architecture and functional contributions of mutation order in FLT3-ITD mutant AML"
Alex Kentsis, MD, PhD
"Mechanism and function of regulatory signaling in acute myeloid leukemia"
with Scott A. Armstrong, MD, PhD, and Ross L. Levine, MD
Bryan C. King, PhD
"AMPK-induced catabolism of extracellular proteins: a novel survival mechanism for nutrient-deprived cancer cells"
with Craig B. Thompson, MD
Piro Lito, MD, PhD
"Modeling the evolution of resistance to ERK signaling inhibitors at the single cell level"
with Neal X. Rosen, MD, PhD, and Charles M. Rudin, MD, PhD
Melody Smith, MD
"CD19 targeted donor T cells improve graft versus tumor activity and reduce graft versus host disease"
with Marcel R.M. van den Brink, MD, PhD
Aaron D. Viny, MD
"Role of the cohesin complex in oncogenic transformation of AML"
with Ross L. Levine, MD
New York University School of Medicine
Lacy J. Barton, PhD
"Mechanisms of directed cell migration in a complex in vivo environment"
with Ruth Lehmann, PhD
Stony Brook University
Benjamin L. Martin, PhD
"Cell cycle regulation of cellular behaviors associated with cancer metastasis"
The Rockefeller University
Aleksey Chudnovskiy, PhD
"Defining dendritic cell-T cell interaction history within the tumor microenvironment using enzymatic labeling"
with Gabriel D. Victora, PhD
Yusong R. Guo, PhD
"Structural and mechanistic characterization of mechanosensitive Piezo channels"
with Roderick MacKinnon, MD
Yadira M. Soto-Feliciano, PhD
"Dissecting the role of Menin in acute leukemia"
with C. David Allis, PhD
Jonathan R. Whicher, PhD
"Structure and mechanism of the voltage-gated potassium channel hEag1"
with Roderick MacKinnon, MD
Weill Cornell Medicine
Christopher E. Barbieri, MD, PhD
"Presurgical trials to target distinct subclasses of localized prostate cancer"
with Lewis C. Cantley, PhD
Duke University
Lawrence A. David, PhD
"Personalized prebiotics to optimize microbiota metabolism and improve transplant outcomes"
University of Texas Southwestern Medical Center
Lindsay B. Case, PhD
"Regulation of integrin clustering on supported lipid bilayers"
with Michael Rosen, PhD
Elise C. Jeffery, PhD
"Characterizing a new hematopoietic stem cell niche factor"
with Sean Morrison, PhD
Fred Hutchinson Cancer Research Center
Aude G. Chapuis, MD
"To specify the requirements of CD8+ and CD4+ T cells for successful adoptive transfer in solid tumors"
with Philip D. Greenberg, MD
Tera C. Levin, PhD
"Master microbial manipulators: how hosts are shaped by bacterial infections"
with Harmit S. Malik, PhD
Jeremy I. Roop, PhD
"Defining virus-host co-evolutionary dynamics that underlie the unusually broad HIV neutralizing antibody response in infants"
with Julie M. Overbaugh, PhD
Alistair B. Russell, PhD
"Impact of heterogeneity on the cellular recognition of influenza infection"
with Jesse D. Bloom, PhD
University of Washington
Brian H. Shirts, MD, PhD
"Participatory genetics for defining genotype-phenotype associations of rare cancer variants"
Washington University
Vivek K. Arora, MD, PhD
"Defining a targetable oncogenic dyad in bladder cancer"
with Lee Ratner, MD, PhD
Gavin P. Dunn, MD, PhD
"Characterizing the immunogenic landscape of glioblastoma"
with John F. DiPersio, MD, PhD, and Robert D. Schreiber, PhD
Stephen T. Oh, MD, PhD
"Targeting aberrant signaling pathways in myeloproliferative neoplasms"
with Daniel C. Link, MD
