Select a highlighted state to learn more about the scientists
and projects that Damon Runyon is currently funding.
Scientists by State
City of Hope
L. Elizabeth Budde, MD, PhD
"Targeting CD123 using chimeric antigen receptor T cells for treatment of acute myeloid leukemia"
with Stephen J. Forman, MD, FACP
Stanford University
Ami S. Bhatt, MD, PhD
"Applying microbiome-based therapeutics in cancer patients"
with Linda Boxer, MD, PhD, and Michael Snyder, PhD
Christopher J. Cambier, PhD
"In vivo characterization of mycobacterial cording"
with Carolyn Bertozzi, PhD
Jennifer L. Caswell-Jin, MD
"Breast cancer evolution and resistance in response to HER2-targeted therapy"
with Christina N. Curtis, PhD, and Allison W. Kurian, MD, MSc
Ryan A. Flynn, MD, PhD
"The interplay between cellular metabolism and RNA homeostasis in disease"
with Carolyn R. Bertozzi, PhD
Victoria Hung, PhD
"Defining the post-translational landscape of ribosomes in control of gene regulation and cell fate"
with Maria Barna, PhD
John C. Janetzko, PhD
"A biophysical approach to studying GRK-GPCR complexes"
with Brian K. Kobilka, MD
David M. Kurtz, MD, PhD
"Response prediction and personalized therapy from mathematical modeling of circulating tumor DNA in non-Hodgkin lymphoma"
with Arash A. Alizadeh, MD, PhD
Kathrin Leppek, PhD
"Mechanistic characterization of 5’UTR RNA elements that confer translational specificity to shape vertebrate embryonic development"
with Maria Barna, PhD
Chuan Li, PhD
Quantifying epistasis among tumor suppressor genes and revealing the underlying expression profiles at the single-cell level
with Dmitri Petrov, PhD
Fangfei Qu, PhD
"Decoding the molecular and cellular mechanisms underlying the growth of brain metastases"
with Julien Sage, PhD
Jianjin Shi, PhD
"Biochemical and genetic dissection of axon degeneration"
with Marc Tessier-Lavigne, PhD
Shaogeng (Steven) Tang, PhD
"Toward small-molecule inhibitors against human immune checkpoint PD-1"
with Peter S. Kim, PhD
Kathryn R. Taylor, PhD
"The effect of neuronal activity on pediatric glioma invasion"
with Michelle L. Monje, MD, PhD
Albert G. Tsai, MD, PhD
"Diagnosis of hematologic malignancies from paucicellular aspirate material using highly multiplexed single cell analysis"
with Sean Bendall, PhD
Jing Lin Xie, PhD
"Remembering the past: epigenetic mechanisms of cancer drug resistance"
with Daniel F. Jarosz, PhD
The Salk Institute for Biological Studies
Corina E. Antal, PhD
"Stromal reprogramming as a therapeutic approach in pancreatic cancer"
with Ronald M. Evans, PhD
The Scripps Research Institute
Marsha M. Hirschi, PhD
Molecular engineering of an optically controlled glutamate receptor
with Gabriel C. Lander, PhD
University of California, Berkeley
Gina V. Caldas, PhD
"Analysis of CSR- function in C. elegans embryonic cell division"
with Abby F. Dernburg, PhD
Allison Didychuk, PhD
Viral mimics of host transcription factors in oncogenic herpesviruses
with Britt Glaunsinger, PhD
Stephanie Gates, PhD
Decoding the ubiquitin receptor recognition mechanism of the 26S proteasome
with Andreas Martin, PhD
Jamie Lahvic, PhD
Uncovering cell non-autonomous mechanisms of tumor suppression
with Iswar Hariharan, MMBS, PhD
Andrew C. Murley, PhD
"Cell non-autonomous communication of ER stress resistance"
with Andrew G. Dillin, PhD
University of California, Los Angeles
Magdalena E. Potok, PhD
"The relationship between epigenetic gene silencing, nuclear architecture, and genome stability"
with Steven E. Jacobsen, PhD
University of California, San Francisco
Özlem Aksoy, PhD
"Understanding the role of translational control in humanized mouse models for medulloblastoma"
with Davide Ruggero, PhD
Collin M. Blakely, MD, PhD
"Mechanisms of incomplete response and primary resistance to osimertinib in EGFR-mutant lung cancer"
with Trever G. Bivona, MD, PhD
Vladislav Belyy, PhD
"Mapping the unfolded protein response signaling network with optogenetic actuators"
with Peter Walter, PhD
Julia C. Carnevale, MD
"Developing new therapeutic approaches for pancreatic cancer with homologous recombination repair defects"
with Alan Ashworth, PhD
Kyle G. Daniels, PhD
"Controlling T cell signaling and fate choice using synthetic receptors"
with Wendell Lim, PhD
Jeffrey A. Hussmann, PhD
"Genome-wide measurement of ribosome spacing on individual transcripts"
with Carol Gross, PhD
Brian J. Laidlaw, PhD
"Role of EBI2 in the regulation of lymphocyte migration during viral infection and cancer"
with Jason Cyster, PhD
Kara L. McKinley, PhD
"Mechanisms and functions of cellular rearrangements in epithelia"
with Ronald D. Vale, PhD
Lyndsay M. Murrow, PhD
"Fate specification of mammary stem cells by cell self-sorting"
with Zev J. Gartner, PhD
Trang Nguyen, PhD
Bypassing the unresponsiveness of T cell anergy and exhaustion
with Arthur Weiss, MD, PhD
Thomas M. Norman, PhD
"Identifying the stochastic determinants of drug resistance"
with Jonathan S. Weissman, PhD
Catherine C. Smith, MD
"Defining structure, function and therapeutic impact of oncogenic FLT3 mutations"
with Neil P. Shah, MD, PhD
Linda T. Vo, PhD
"Off-the-shelf T cells from human pluripotent stem cells with precise tumor recognition using combinatorial antigen-sensing circuits"
with Jeff A. Bluestone, PhD
Yichen Xu, PhD
"Elucidating a non-classical role of ER in gene expression and breast cancer progression"
with Davide Ruggero, PhD
Dian Yang, PhD
Dissecting intratumoral heterogeneity and hierarchy at single cell resolution
with Jonathan S. Weissman, PhD, and Trever G. Bivona, MD, PhD
Ziyang Zhang, PhD
"Controlling the activity of bispecific T cell engagers with a chemically cleavable molecular switch"
with Kevan M. Shokat, PhD
Yale University
Esen Sefik, PhD
"The effect of microbes, diet on the intestinal immune system in the context of obesity and cancer"
with Richard A. Flavell, PhD
The University of Chicago
Michael W. Drazer, MD
"Defining leukomogenic mechanisms in hereditary hematologic malignancies"
with Lucy A. Godley, MD, PhD
National Institutes of Health
Danfeng Cai, PhD
"Protein crowding and protein folding landscapes as predictors of healthy and diseased cell states"
with Jennifer Lippincott-Schwartz, PhD
The Johns Hopkins University
Stacy L. Cooper, MD
"The Cebpa +37kb enhancer is a critical target of transformation in acute myeloid leukemia"
with Alan D. Friedman, MD
Daniel H. Goldman, PhD
"Elucidating the role of the exon junction complex in regulating translation of spliced mRNA"
with Rachel Green, PhD
Michael A. Koldobskiy, MD, PhD
"DNA methylation stochasticity in pediatric pre-B cell acute lymphoblastic leukemia"
with Andrew P. Feinberg, MD
The Johns Hopkins University School of Medicine
Xintong Dong, PhD
"Investigating ligand-receptor interactions between defensins and mrgprs in cutaneous inflammation and wound healing"
with Xinzhong Dong, PhD
Evan J. Worden, PhD
"The mechanistic basis of crosstalk between histone H2B ubiquitylation and H3K79 methylation"
with Cynthia Wolberger, PhD
Boston Children's Hospital
Megan Insco, MD, PhD
"Investigating transcriptional cyclin dependent kinases as novel melanoma drug targets"
with Len Zon, MD
Brigham and Women's Hospital
Ann Mullally, MD
"Determining the role of aberrant growth factor signaling in maintaining disease-propagating cells and mediating JAK2 inhibitor resistance in myeloproliferative neoplasms"
with Benjamin L. Ebert, MD, PhD, and Jerome Ritz, MD
Dana-Farber Cancer Institute
Pavan Bachireddy, MD
"Coevolution of tumor and T cell heterogeneity following immunotherapy"
with Catherine J. Wu, MD
Giada Bianchi, MD
"Molecular mechanisms of ROBO1 in multiple myeloma pathogenesis"
with Kenneth C. Anderson, MD
Phillip A. Dumesic, MD, PhD
"Identification of muscle-secreted factors responsible for local and systemic effects of exercise"
with Bruce M. Spiegelman, PhD
Adam D. Durbin, MD, PhD
Interrogation of neuroblastoma dependencies and non-coding RNAs on the core-regulatory circuitry for therapeutic inhibition
with A. Thomas Look, MD
Eric S. Fischer, PhD
"Novel mechanisms for small molecule induced targeted degradation of RRM family proteins"
Christopher J. Gibson, MD
"Elucidating the connection between clonal hematopoiesis and lymphoma in humans"
with Benjamin L. Ebert, MD, PhD
Lillian M. Guenther, MD
"Investigation of CITED2 as a novel dependency in Ewing sarcoma"
with Kimberly Stegmaier, MD
Tikvah K. Hayes, PhD
"Systematic genomic and functional analysis of small cell lung cancer"
with Matthew L. Meyerson, MD, PhD
Amanda Balboni Iniguez, PhD
"Targeting the EWS-FLI oncoprotein in Ewing sarcoma with CDK12/13 inhibitors"
with Kimberly Stegmaier, MD
Whitney Johnson, PhD
Using organoid cancer models to identify genome catastrophe mechanisms
with David Pellman, MD
Loretta S. Li, MD
"Mechanisms of disease and resistance in CRLF2-rearranged B-cell acute lymphoblastic leukemia"
with David M. Weinstock, MD
Sarah Naomi Olsen, PhD
Targeted degradation of the MLL-AF9 fusion oncoprotein in acute myeloid leukemia
with Scott A. Armstrong, MD, PhD
Geoffrey R. Oxnard, MD
"Noninvasive genotyping of cell-free plasma DNA (cfDNA) as a tool for guiding personalized lung cancer care"
with Pasi A. Janne, MD, PhD
Harshabad Singh, MBBS
"Cellular origins of Barrett’s esophagus and its role in development of adenocarcinoma"
with Ramesh A. Shivdasani, MD, PhD
Neil T. Umbreit, PhD
"Elucidating the mechanism of chromosome bridge resolution"
with David S. Pellman, MD
Eliezer M. Van Allen, MD
"Dissecting response to conventional and emerging DNA damage and repair therapies"
with Geoffrey I. Shapiro, MD, PhD
Harvard Medical School
Justin A. Bosch, PhD
"Characterizing novel molecules and mechanisms that mediate cell-cell communication"
with Norbert Perrimon, PhD
Anne E. Dodson, PhD
"Transgenerational inheritance of structure-based infections"
with Scott G. Kennedy, PhD
Ivana Gasic, Dr.Sc.
"Molecular elucidation of the interphase microtubule integrity response (MIR)"
with Timothy Mitchison, PhD
Lucy Liu, PhD
"In vivo characterization of muscle autophagy