Select a highlighted state to learn more about the scientists
and projects that Damon Runyon is currently funding.
Scientists by State
California Institute of Technology
Bo Gu, PhD
"Understanding and engineering combinatorial gene regulation in mammalian cells"
with Michael B. Elowitz, PhD
Stanford University
Debadrita Bhattacharya, PhD
"Investigating molecular and cellular mechanisms of intra-tumoral heterogeneity in small-cell lung cancer"
with Julien Sage, PhD
Felix C. Boos, PhD
"Inter-organ communication of protein homeostasis stress responses in vertebrate aging"
with Anne Brunet, PhD
Lauren E. Cote, PhD
"Constructing one continuous digestive tract, cell by cell"
with Jessica L. Feldman, PhD
Daniel J. Delitto, MD, PhD
"Pathogen sensing in fibroblasts restrains antitumor immunity in pancreatic cancer"
with Michael T. Longaker, MD, DSc
Seungsoo Kim, PhD
"Transcription factor cooperation shaping TWIST1 multifunctionality across craniofacial development and cancer metastasis"
with Joanna K. Wysocka, PhD
Conor J. McClune, PhD
"Resolving plant biosynthesis of therapeutic compounds by systematic perturbation, measurement, and metabolic phenotyping at single-cell scale"
with Elizabeth S. Sattely, PhD, and Polly M. Fordyce, PhD
Kavita Y. Sarin, MD, PhD
"Genetic contributions and novel therapies for individuals with frequent basal cell cancer"
with Jean Y. Tang, MD, PhD, and Anthony E. Oro, MD, PhD
Stanford University School of Medicine
Caitlin F. Bell, MD
"Smooth muscle cell plasticity in the tumor microenvironment: another parallel between atherosclerosis and cancer"
with Nicholas J. Leeper, MD, and Irving L. Weissman, MD
Ali Lashkaripour, PhD
"High-throughput biomimetic screening of T cell activation in large sequence landscapes"
with Polly M. Fordyce, PhD
The Scripps Research Institute
Danielle Grotjahn, PhD
"Uncovering structural mechanisms of mitochondrial fragmentation in cancer by cellular cryo-electron tomography"
Haoxin Li, PhD
"Cysteine-modification screening to identify functional and druggable sites in cancer dependencies"
with Benjamin F. Cravatt, PhD
University of California, Berkeley
Ben F. Brian, PhD
"Mechanisms and consequences of microbiota-directed immune responses"
with Gregory M. Barton, PhD
Gabriel Cavin-Meza, PhD
"Leveraging polyploid Xenopus to probe spindle adaptation to increases in genome size"
with Rebecca W. Heald, PhD
Timothy J. Eisen, PhD
"Mechanistic dissection of Tec kinases in immune-cell signaling"
with Jay Groves, PhD and John Kuriyan, PhD
Katy Ong, PhD
"Long-range tumor-host signaling mechanisms driving paraneoplastic syndromes"
with David Bilder, PhD
Joshua B. Sheetz, PhD
"Mitochondrial ubiquitylation mechanisms to exploit metabolic vulnerabilities in cancer"
with Michael Rape, PhD
Jiao Sima, PhD
"Cellular mechanisms linking sleep disturbance and cancer development"
with Yang Dan, PhD
University of California, Los Angeles
Yajing Gao, PhD
"Characterize the role of non-vesicular cholesterol transport in CD8+ T cell function"
with Peter Tontonoz, MD, PhD
University of California, San Francisco
Collin M. Blakely, MD, PhD
"Mechanisms of incomplete response and primary resistance to the 3rd generation EGFR inhibitor osimertinib in lung cancer"
with Trever G. Bivona, MD, PhD
Fangyu Liu, PhD
"Discovery of novel ligands that treat metabolic disorders"
with Brian K. Shoichet, PhD
Tadashi Manabe, MD, PhD
"Characterization of oncogenic kinase signaling by membraneless cytoplasmic protein granules"
with Trever G. Bivona, MD, PhD
David Y. Oh, MD, PhD
"Co-receptors modulating anti-tumor activity of human cytotoxic CD4+ effector cells"
with Lawrence Fong, MD
Tristan Wold Owens, PhD
"Molecular mechanisms of heat shock transcription factor 1 in cancer"
with David A. Agard, PhD
Fanglue Peng, PhD
"Humanize CXCL13 expression in mouse to understand lymphoid neogenesis in cancer"
with Jason G. Cyster, PhD
Erron W. Titus, MD, PhD
"Engineered cellular fusogens for novel immune effector functions"
with Matthew F. Krummel, PhD
Kouki Touhara, PhD
"Investigating chemical signaling between gut enteroendocrine cells and intrinsic primary afferent neurons"
with David J. Julius, PhD
University of Colorado Boulder
Edward M. C. Courvan, PhD
"Functional analysis of post-transcriptional RNA regulation in hypoxic macrophages"
with Roy R. Parker, PhD
Dylan M. Parker, PhD
"Stress granule regulators and their roles in cancer progression"
with Roy R. Parker, PhD
Yale University School of Medicine
Luisa F. Escobar-Hoyos, PhD
"Understanding RNA splicing in tumor-cell adaptation and anti-tumor immunity"
The Johns Hopkins University School of Medicine
Marco A. Catipovic, PhD
"In vitro reconstitution of ribosome collision dependent signaling”
with Rachel Green, PhD
Cayla E. Jewett, PhD
"Mechanisms of centriole number control in multiciliated cells"
with Andrew J. Holland, PhD
Dana-Farber Cancer Institute
Sylvan C. Baca, MD, PhD
"Epigenetic drivers of resistance to novel therapies for bladder and kidney cancer"
with Toni K. Choueiri, MD
Wallace A. Bourgeois, MD
"Targeting JMJD1C and IKZF1 as therapeutic opportunities in KMT2A-rearranged leukemia"
with Scott A. Armstrong, MD, PhD
Anders B. Dohlman, PhD
"Identifying the genomic basis for Fusobacterium nucleatum’s colonization of colorectal cancers"
with Matthew L. Meyerson, MD, PhD
(Peter) Geon Kim, MD
"Elucidating the mechanisms of inflammation in clonal hematopoiesis"
with Benjamin L. Ebert, MD, PhD
Matthew G. Oser, MD, PhD
"Dissecting and therapeutically exploiting synthetic lethality between NOTCH and TRIM28 to drive anti-tumor immunity in SCLC"
with William G. Kaelin, Jr., MD
Mounica Vallurupalli, MD
"Defining the mechanistic implications of SF3B1 mutations in MDS"
with Todd R. Golub, MD
Srinivas R. Viswanathan, MD, PhD
"X marks the spot: exploring how X-chromosome alterations drive sex differences in cancer"
David M. Walter, PhD
"Identifying the selective mechanism behind U2AF1 mutations in lung adenocarcinoma"
with Matthew L. Meyerson, MD, PhD
Dana-Farber Cancer Institute / Harvard Medical School
Archana Krishnamoorthy, PhD
"Mechanisms of chromosome fragmentation generating chromothripsis"
with David S. Pellman, MD, and Johannes Walter, PhD
Harvard Medical School
Erin Duffy, PhD
"Activity-dependent changes in RNA stability as a mechanism for synaptic plasticity"
Lucas Farnung, PhD
"Understanding the mechanistic basis of gene expression regulation by MLL complexes in cancers"
Rachel Segal Greenberg, PhD
"Developing functional diversity in interoceptive circuits"
with Stephen D. Liberles, PhD
Hannah A. Grunwald, PhD
"Unraveling the role of molecular capacitors that obscure cryptic genetic variants in fish"
with Clifford J. Tabin, PhD
Xin Gu, PhD
"Characterization of a novel pathway regulating the protein degradation of immediate-early genes"
with Michael E. Greenberg, PhD
Manuel Osorio Valeriano, PhD
"Molecular and structural basis of gene expression regulation by the nucleosome remodeling and deacetylase (NuRD) complex in human cancer"
with Lucas Farnung, PhD, and Danesh Moazed, PhD
Harvard T.H. Chan School of Public Health
Madi Y. Cissé, PhD
"Integration on oncogenic signaling and nutrient sensing by mTOR in tumors"
with Brendan D. Manning, PhD
Harvard University
Alon Chappleboim, PhD
"Uncovering signaling mechanisms in somitogenesis through high-throughput genetic screens in robust human organoids"
with Sharad Ramanathan, PhD
Rongxin Fang, PhD
"Genome-scale imaging of enhancer-promoter interactions in cancer at single cell resolution"
with Xiaowei Zhuang, PhD
Massachusetts General Hospital
Charles H. Adelmann, PhD
"Systematic exploration of the organellar and cellular requirements of pigmentation"
with David E. Fisher, MD, PhD
Albert E. Kim, MD
"Using liquid biopsy and MRI to non-invasively identify therapeutic targets for brain metastases"
with Priscilla K. Brastianos, MD, and Elizabeth R. Gerstner, MD
Mark B. Leick, MD
"Engineering novel CAR T cells for AML: translating lessons from correlative studies and other diseases"
with Marcela V. Maus, MD, PhD
Massachusetts Institute of Technology
Michael E. Birnbaum, PhD
"Decoding and reprogramming tumor-infiltrating T cells by pMHC-targeted lentiviruses"
Fangtao Chi, PhD
"Understanding how ketone body metabolites influence intestinal stemness, immune responses and tumorigenesis"
with Ömer H. Yilmaz, MD, PhD
Isabella Fraschilla, PhD
"Examining bacteria as a source of tumor antigens"
with Tyler E. Jacks, PhD
J. Scott P. McCain, PhD
"Estimating growth rates and fluxes using gene expression: Theory and applications"
with Gene-Wei Li, PhD
Jon McGinn, PhD
"Dissecting the genetic networks underlying host subversion during Rickettsia infection"
with Rebecca Lamason, PhD
Senén D. Mendoza, PhD
"Discovery and characterization of bacterial immunity against RNA phages"
with Michael T. Laub, PhD
Whitehead Institute for Biomedical Research
Jingchuan Luo, PhD
"Deciphering roles of nuclear-mitochondrial communication in cellular homeostasis"
with Jonathan S. Weissman, PhD
Ryan Y. Muller, PhD
"Excised stable introns of Epstein-Barr virus: functions and mechanisms"
with David P. Bartel, PhD
University of Michigan
Phillip L. Palmbos, MD, PhD
"Targeting TRIM29 to reverse immune checkpoint inhibitor resistance in bladder cancer"
with Joshi J. Alumkal, MD
University of Minnesota
Nicholas N. Jarjour, PhD
"Antigen-independent proliferation of tissue-resident memory T cells and therapeutic applications"
with Stephen C. Jameson, PhD
Princeton University
Grace E. Johnson, PhD
"Defining quorum-sensing signaling patterns and their effects on gene expression and morphology in V. cholerae biofilms at the single-cell and community levels"
with Bonnie L. Bassler, PhD
Aaron E. Lin, PhD
"Contact tracing within an organism: developing a genome editing platform to record the history of virus-infected and transformed cells"
with Alexander Ploss, PhD, and Brittany Adamson, PhD
Titas Sengupta, PhD
"Investigating bacterial small RNA-mediated regulation of host behavior"
with Coleen T. Murphy, PhD
Carolina Trenado-Yuste, PhD
"Screening migratory modes and drug delivery schedules in 3D spheroids of triple-negative breast cancer cells"
with Celeste M. Nelson, PhD, and Ned S. Wingreen, PhD
Columbia University
James Swann, VetMB, DPhil
"Emergency myelopoiesis pathways as common drivers of clonal dominance and disease progression in acute myeloid leukemia"
with Emmanuelle Passegué, PhD
Aaron D. Viny, MD
"Epigenetic coupling of DNA methylation and chromatin structure on leukemic transformation and therapeutic response"
with Emmanuelle Passegué, PhD, and Joseph G. Jurcic, MD
Icahn School of Medicine at Mount Sinai
Andrew L. Ji, MD
"Dissecting spatial crosstalk in squamous cell carcinoma arising in organ transplant recipients"
with Miriam Merad, MD, PhD
Memorial Sloan Kettering Cancer Center
Kaixian Liu, PhD
"The studies of double-strand break proteins in germline genome transmission"
with Scott N. Keeney, PhD, and Shixin Liu, PhD
Elli Papaemmanuil, PhD
"Leveraging multi-modal genome profiling approaches to study disease initiation, progression, and response to therapy in TP53 mutated myeloid neoplasms"
Memorial Sloan Kettering Institute for Cancer Research
Rico C. Ardy, PhD
"An atlas of fibroblast cell states in health and disease through functional genomics"
with Thomas Norman, PhD
New York University Grossman School of Medicine
Nicholas M. Adams, PhD
"Elucidating how pDC genome organization regulates IFN production in cancer"
with Boris Reizis, PhD
The Rockefeller University
Nicole M. Cruz, MD
"Understanding the role of KMT2D in MLL-AF9 acute myeloid leukemia"
with Robert G. Roeder, PhD
Catherine A. Freije, PhD
"Investigating the role of fitness and host pressure in shaping hepatitis B diversity"
with Charles M. Rice, PhD
Anita Gola, PhD
"A spatially patterned stem cell and immune cell barrier at the skin surface"
with Elaine V. Fuchs, PhD
Mira A. Patel, MD
"Molecular mechanisms of human APOE-mediated myeloid cell modulation in cancer"
with Sohail F. Tavazoie, MD, PhD
Gokhan Unlu, PhD
"Targeting cancer nutrient limitations using dietary interventions"
with Kivanç Birsoy, PhD
University of Pennsylvania
Alexander C. Huang, MD
"Shared antigen and neoantigen-specific T cells in checkpoint blockade efficacy and toxicity"
with Gerald P. Linette, MD, PhD
Nicholas P. Lesner, PhD
"Hepatic urea cycle function in NASH-induced HCC progression"
with M. Celeste Simon, PhD
Rebecca S. Moore, PhD
"Investigation of the role of peripheral secreted molecules on sleep and circadian rhythms"
with Amita Sehgal, PhD
Christopher Noetzel, PhD
"How do eukaryotic cells count cell cycles? Intrinsic regulation of quantized asexual replication cycles and commitment to sexual differentiation in the protozoan parasite Cryptosporidium parvum"
with Boris Striepen, PhD
University of Pittsburgh
Dennis J. Hsu, MD
"Metabolic determinants of codon usage bias in colorectal cancer"
with Jeremy N. Rich, MD
Yvonne M. Mowery, MD, PhD
"Evaluating and targeting pathways of treatment resistance in head and neck squamous cell carcinoma"
with Heath D. Skinner, MD, PhD, and Robert L. Ferris, MD, PhD
St. Jude Children's Research Hospital
Lillian M. Guenther, MD
"Investigation of CITED2 as a novel dependency in Ewing sarcoma"
with Mark E. Hatley, MD, PhD
The University of Texas MD Anderson Cancer Center
Pavan Bachireddy, MD
"Immune evasive circuits that define MRD progression in myelodysplastic syndrome"
with Jeffrey J. Molldrem, MD
University of Texas Southwestern Medical Center
Todd A. Aguilera, MD, PhD
"Immunologic responses to short course radiotherapy in rectal adenocarcinoma and the impact of CD40 agonist immunotherapy"
with Robert D. Timmerman, MD
Fred Hutchinson Cancer Research Center
Edie I. Crosse, PhD
"Precision therapeutics for hematologic malignancies with splicing factor mutations"
with Robert Bradley, PhD
Christopher P. Lapointe, PhD
“Fundamental mechanisms that underlie human translation initiation and its dysregulation in cancer”
Siqi Li, PhD
"Deciphering clonal competition between oncogenic mutant and normal cells and its effect on cancer initiation"
with Slobodan Beronja, PhD
University of Washington
Wei (Will) Chen, PhD
"Decoding the transcription code: de novo protein design for precise gene regulation"
with David Baker, PhD
Jean-Benoît Lalanne, PhD
"At-scale dissection of developmental enhancers with single-cell reporters"
with Jay A. Shendure, MD, PhD
Nicholas C. Lammers, PhD
"A computational platform for predicting whole-embryo morphologies from single-cell transcriptomes"
with Cole Trapnell, PhD, and David Kimelman, PhD
