Select a highlighted state to learn more about the scientists
and projects that Damon Runyon is currently funding.
Scientists by State
California Institute of Technology
Bo Gu, PhD
"Understanding and engineering combinatorial gene regulation in mammalian cells"
with Michael B. Elowitz, PhD
Stanford University
Debadrita Bhattacharya, PhD
"Investigating molecular and cellular mechanisms of intra-tumoral heterogeneity in small-cell lung cancer"
with Julien Sage, PhD
Felix C. Boos, PhD
"Inter-organ communication of protein homeostasis stress responses in vertebrate aging"
with Anne Brunet, PhD
Lauren E. Cote, PhD
"Constructing one continuous digestive tract, cell by cell"
with Jessica L. Feldman, PhD
Daniel J. Delitto, MD, PhD
"Pathogen sensing in fibroblasts restrains antitumor immunity in pancreatic cancer"
with Michael T. Longaker, MD, DSc
Christina L. Hueschen, PhD
"Molecular basis and regulation of apicomplexan parasite motility"
with Alex Dunn, PhD
Seungsoo Kim, PhD
"Transcription factor cooperation shaping TWIST1 multifunctionality across craniofacial development and cancer metastasis"
with Joanna K. Wysocka, PhD
Conor J. McClune, PhD
"Resolving plant biosynthesis of therapeutic compounds by systematic perturbation, measurement, and metabolic phenotyping at single-cell scale"
with Elizabeth S. Sattely, PhD, and Polly M. Fordyce, PhD
Kavita Y. Sarin, MD, PhD
"Genetic contributions and novel therapies for individuals with frequent basal cell cancer"
with Jean Y. Tang, MD, PhD, and Anthony E. Oro, MD, PhD
Melody Smith, MD
"Regulatory mechanisms of the intestinal microbiome on chimeric antigen receptor T cells"
with Robert S. Negrin, MD
Stanford University School of Medicine
Caitlin F. Bell, MD
"Smooth muscle cell plasticity in the tumor microenvironment: another parallel between atherosclerosis and cancer"
with Nicholas J. Leeper, MD, and Irving L. Weissman, MD
Yiming Chen, PhD
"Optical interrogation of neuropeptide and peptide hormones"
with Karl Deisseroth, MD, PhD
Shuo Han, PhD
"Spatiotemporally precise manipulation of Hedgehog signaling for tissue regeneration and repair"
with Philip A. Beachy, PhD
Anusha Kalbasi, MD
"IL13Ra2 Chimeric Antigen Receptor (CAR) T cells for metastatic melanoma"
with Crystal L. Mackall, MD
Christopher P. Lapointe, PhD
“Fundamental mechanisms that underlie human translation initiation and its dysregulation in cancer”
Ali Lashkaripour, PhD
"High-throughput biomimetic screening of T cell activation in large sequence landscapes"
with Polly M. Fordyce, PhD
The Salk Institute for Biological Studies
Hokyung K. Chung, PhD
"Next generation adoptive cell therapy: SMARTER T cells for enhanced and durable anti-tumor immunity"
with Susan M. Kaech, PhD
Thomas H. Mann, PhD
"Calcium signaling and the molecular clock of T cell exhaustion"
with Susan M. Kaech, PhD
The Scripps Research Institute
Danielle Grotjahn, PhD
"Uncovering structural mechanisms of mitochondrial fragmentation in cancer by cellular cryo-electron tomography"
Haoxin Li, PhD
"Cysteine-modification screening to identify functional and druggable sites in cancer dependencies"
with Benjamin F. Cravatt, PhD
University of California, Berkeley
Ben F. Brian, PhD
"Mechanisms and consequences of microbiota-directed immune responses"
with Gregory M. Barton, PhD
Timothy J. Eisen, PhD
"Mechanistic dissection of Tec kinases in immune-cell signaling"
with John Kuriyan, PhD
Katy Ong, PhD
"Long-range tumor-host signaling mechanisms driving paraneoplastic syndromes"
with David Bilder, PhD
Joshua B. Sheetz, PhD
"Mitochondrial ubiquitylation mechanisms to exploit metabolic vulnerabilities in cancer"
with Michael Rape, PhD
Jiao Sima, PhD
"Cellular mechanisms linking sleep disturbance and cancer development"
with Yang Dan, PhD
University of California, Los Angeles
Yajing Gao, PhD
"Characterize the role of non-vesicular cholesterol transport in CD8+ T cell function"
with Peter Tontonoz, MD, PhD
University of California, San Francisco
Collin M. Blakely, MD, PhD
"Mechanisms of incomplete response and primary resistance to the 3rd generation EGFR inhibitor osimertinib in lung cancer"
with Trever G. Bivona, MD, PhD
Benjamin G. H. Guthrie, PhD
"Fluoropyrimidine bioactivation and metabolism by the gut microbiome"
with Peter J. Turnbaugh, PhD
Fangyu Liu, PhD
"Discovery of novel ligands that treat metabolic disorders"
with Brian K. Shoichet, PhD
Tadashi Manabe, MD, PhD
"Characterization of oncogenic kinase signaling by membraneless cytoplasmic protein granules"
with Trever G. Bivona, MD, PhD
David Y. Oh, MD, PhD
"Co-receptors modulating anti-tumor activity of human cytotoxic CD4+ effector cells"
with Lawrence Fong, MD
Tristan Wold Owens, PhD
"Molecular mechanisms of heat shock transcription factor 1 in cancer"
with David A. Agard, PhD
Cristina Puchades, PhD
"Deciphering the molecular basis for modulation of TMEM16A activity"
with Yifan Cheng, PhD, and Lily Jan, PhD
Zulekha A. Qadeer, PhD
"Targeting TGFb pathway dependencies in Group 3 Medulloblastoma"
with William A. Weiss, MD, PhD
Catherine C. Smith, MD
"RNA Polymerase II as therapeutic target in AML with RAS activation"
with Neil P. Shah, MD, PhD, and Kevin M. Shannon, MD
Erron W. Titus, MD, PhD
"Engineered cellular fusogens for novel immune effector functions"
with Matthew F. Krummel, PhD
Kouki Touhara, PhD
"Investigating chemical signaling between gut enteroendocrine cells and intrinsic primary afferent neurons"
with David J. Julius, PhD
University of Colorado Boulder
Edward M. C. Courvan, PhD
"Functional analysis of post-transcriptional RNA regulation in hypoxic macrophages"
with Roy R. Parker, PhD
Yale University
Elizabeth J. Culp, PhD
"Mechanisms and consequences of microbial transformation of dietary xenobiotics in cancer risk"
with Andrew L. Goodman, PhD
Yale University School of Medicine
Luisa F. Escobar-Hoyos, PhD
"Understanding RNA splicing in tumor-cell adaptation and anti-tumor immunity"
The Johns Hopkins University School of Medicine
Marco A. Catipovic, PhD
"In vitro reconstitution of ribosome collision dependent signaling”
with Rachel Green, PhD
Jonathan C. Dudley, MD
"Earlier detection of cancer in body cavity fluids through aneuploidy analysis after cell enrichment and partitioning"
with Bert Vogelstein, MD
Boston Children's Hospital
Liudmila Andreeva, PhD
"Making an inflammasome: Structural and biochemical elucidation of NLRP3 inflammasome activation"
with Hao Wu, PhD
Aaron L. Moye, PhD
"Role of Lgr6-expressing mesenchymal cells in lung cancer initiation and progression"
with Carla F. Kim, PhD
Esteban A. Orellana Vinueza, PhD
"Role of METTL1-WDR4 tRNA methyltransferase complex in cancer"
with Richard I. Gregory, PhD
Dana-Farber Cancer Institute
Wallace A. Bourgeois, MD
"Targeting JMJD1C and IKZF1 as therapeutic opportunities in KMT2A-rearranged leukemia"
with Scott A. Armstrong, MD, PhD
(Peter) Geon Kim, MD
"Elucidating the mechanisms of inflammation in clonal hematopoiesis"
with Benjamin L. Ebert, MD, PhD
Birgit Knoechel, MD, PhD
"Mechanisms of CD8+ T-cell dysfunction and its therapeutic targeting in T-ALL"
with Kimberly Stegmaier, MD, and Catherine J. Wu, MD
Matthew G. Oser, MD, PhD
"Dissecting and therapeutically exploiting synthetic lethality between NOTCH and TRIM28 to drive anti-tumor immunity in SCLC"
with William G. Kaelin, Jr., MD
Srinivas R. Viswanathan, MD, PhD
"X marks the spot: exploring how X-chromosome alterations drive sex differences in cancer"
Dana-Farber Cancer Institute / Harvard Medical School
Archana Krishnamoorthy, PhD
"Mechanisms of chromosome fragmentation generating chromothripsis"
with David S. Pellman, MD, and Johannes Walter, PhD
Harvard Medical School
Lucas Farnung, PhD
"Understanding the mechanistic basis of gene expression regulation by MLL complexes in cancers"
Pragya Goel, PhD
"Signaling structure for neuromodulatory coding in the vertebrate striatum"
with Pascal Kaeser, MD
Rachel Segal Greenberg, PhD
"Developing functional diversity in interoceptive circuits"
with Stephen D. Liberles, PhD
Hannah A. Grunwald, PhD
"Unraveling the role of molecular capacitors that obscure cryptic genetic variants in fish"
with Clifford J. Tabin, PhD
Xin Gu, PhD
"Characterization of a novel pathway regulating the protein degradation of immediate-early genes"
with Michael E. Greenberg, PhD
James Osei-Owusu, PhD
"Structure and inhibition of the relaxin receptor RXFP1"
with Andrew C. Kruse, PhD
Manuel Osorio Valeriano, PhD
"Molecular and structural basis of gene expression regulation by the nucleosome remodeling and deacetylase (NuRD) complex in human cancer"
with Lucas Farnung, PhD, and Danesh Moazed, PhD
Deepshika Ramanan, PhD
"Identifying functions of regulatory T cell subsets in intestinal inflammation and colorectal cancer"
Harvard T.H. Chan School of Public Health
Madi Y. Cissé, PhD
"Integration on oncogenic signaling and nutrient sensing by mTOR in tumors"
with Brendan D. Manning, PhD
Harvard University
Rongxin Fang, PhD
"Genome-scale imaging of enhancer-promoter interactions in cancer at single cell resolution"
with Xiaowei Zhuang, PhD
Grace E. Kenney, PhD
"New enzymatic routes towards nitrogen-nitrogen bond formation in diverse cytotoxic natural products"
with Emily P. Balskus, PhD
Thomas R. LaBar, PhD
"Elucidating the mechanisms of cellular evolution with experimental evolution"
with Andrew W. Murray, PhD
Massachusetts General Hospital
Charles H. Adelmann, PhD
"Systematic exploration of the organellar and cellular requirements of pigmentation"
with David E. Fisher, MD, PhD
Albert E. Kim, MD
"Using liquid biopsy and MRI to non-invasively identify therapeutic targets for brain metastases"
with Priscilla K. Brastianos, MD, and Elizabeth R. Gerstner, MD
Mark B. Leick, MD
"Engineering novel CAR T cells for AML: translating lessons from correlative studies and other diseases"
with Marcela V. Maus, MD, PhD
Massachusetts Institute of Technology
Michael E. Birnbaum, PhD
"Decoding and reprogramming tumor-infiltrating T cells by pMHC-targeted lentiviruses"
Fangtao Chi, PhD
"Understanding how ketone body metabolites influence intestinal stemness, immune responses and tumorigenesis"
with Ömer H. Yilmaz, MD, PhD
J. Scott P. McCain, PhD
"Circadian clocks in non-photosynthetic bacteria: mechanisms and impacts"
with Gene-Wei Li, PhD
Jon McGinn, PhD
"Dissecting the genetic networks underlying host subversion during Rickettsia infection"
with Rebecca Lamason, PhD
Senén D. Mendoza, PhD
"Discovery and characterization of bacterial immunity against RNA phages"
with Michael T. Laub, PhD
Whitehead Institute for Biomedical Research
Jingchuan Luo, PhD
"Deciphering roles of nuclear-mitochondrial communication in cellular homeostasis"
with Jonathan S. Weissman, PhD
University of Michigan
Phillip L. Palmbos, MD, PhD
"Targeting TRIM29 to reverse immune checkpoint inhibitor resistance in bladder cancer"
with Joshi J. Alumkal, MD
Princeton University
Nir Hananya, PhD
"The roles of histone ADP-ribosylation in DNA damage response"
with Tom W. Muir, PhD
Grace E. Johnson, PhD
"Defining quorum-sensing signaling patterns and their effects on gene expression and morphology in V. cholerae biofilms at the single-cell and community levels"
with Bonnie L. Bassler, PhD
Aaron E. Lin, PhD
"Contact tracing within an organism: developing a genome editing platform to record the history of virus-infected and transformed cells"
with Alexander Ploss, PhD, and Brittany Adamson, PhD
Memorial Sloan Kettering Cancer Center
Tin Yi Chu, PhD
"Statistical modeling of cell-cell interactions in normal intestine, inflammatory bowel disease and colorectal cancer using single cell and spatial transcriptomics"
with Dana Pe’er, PhD, and Elaine V. Fuchs, PhD
Andrew J. Dunbar, MD
"Interrogating functional contribution of JAK2V617F in the maintenance of myeloproliferative neoplasms"
with Ross L. Levine, MD
Siting Gan, PhD
"In situ single-cell dissection of the tumor-microenvironment interplay mediating brain metastasis"
with Joan Massagué, PhD, and Dana Pe'er, PhD
Kaixian Liu, PhD
"The studies of double-strand break proteins in germline genome transmission"
with Scott N. Keeney, PhD, and Shixin Liu, PhD
Elli Papaemmanuil, PhD
"Leveraging multi-modal genome profiling approaches to study disease initiation, progression, and response to therapy in TP53 mutated myeloid neoplasms"
José Reyes, PhD
"Dynamics and consequences of complex karyotype evolution in p53 driven acute myeloid leukemia"
with Scott W. Lowe, PhD, and Dana Pe'er, PhD
Memorial Sloan Kettering Institute for Cancer Research
Rico C. Ardy, PhD
"An atlas of fibroblast cell states in health and disease through functional genomics"
with Thomas Norman, PhD
New York University Grossman School of Medicine
Nicholas M. Adams, PhD
"Elucidating how pDC genome organization regulates IFN production in cancer"
with Boris Reizis, PhD
The Rockefeller University
Catherine A. Freije, PhD
"Investigating the role of fitness and host pressure in shaping hepatitis B diversity"
with Charles M. Rice, PhD
Anita Gola, PhD
"A spatially patterned stem cell and immune cell barrier at the skin surface"
with Elaine V. Fuchs, PhD
Mira A. Patel, MD
"Molecular mechanisms of human APOE-mediated myeloid cell modulation in cancer"
with Sohail F. Tavazoie, MD, PhD
Gokhan Unlu, PhD
"Targeting cancer nutrient limitations using dietary interventions"
with Kivanç Birsoy, PhD
University of Pennsylvania
Alexander C. Huang, MD
"Shared antigen and neoantigen-specific T cells in checkpoint blockade efficacy and toxicity"
with Gerald P. Linette, MD, PhD
Nicholas P. Lesner, PhD
"Hepatic urea cycle function in NASH-induced HCC progression"
with M. Celeste Simon, PhD
Rebecca S. Moore, PhD
"Investigation of the role of peripheral secreted molecules on sleep and circadian rhythms"
with Amita Sehgal, PhD
Christopher Noetzel, PhD
"How do eukaryotic cells count cell cycles? Intrinsic regulation of quantized asexual replication cycles and commitment to sexual differentiation in the protozoan parasite Cryptosporidium parvum"
with Boris Striepen, PhD
Catherine Triandafillou, PhD
"Intrinsic and extrinsic drivers of heterogeneous drug resistance in cancer"
with Arjun Raj, PhD
St. Jude Children's Research Hospital
Katherine E. Gadek, PhD
"Defining endothelial progenitor cell pliancy in rhabdomyosarcoma"
with Mark Hatley, MD, PhD, and Stacey Ogden, PhD
The University of Texas MD Anderson Cancer Center
Xiuning Le, MD, PhD
"Structure- and lineage-based classification and targeting of resistance in EGFR-mutant NSCLC"
with John V. Heymach, MD, PhD
Natalie Vokes, MD
"Dissecting tumor intrinsic and immune drivers of resistance to therapy in non-small cell lung cancer"
with John V. Heymach, MD, PhD
University of Texas Southwestern Medical Center
Todd A. Aguilera, MD, PhD
"Immunologic responses to short course radiotherapy in rectal adenocarcinoma and the impact of CD40 agonist immunotherapy"
with Robert D. Timmerman, MD
David G. McFadden, MD, PhD
"Identifying metabolic vulnerabilities in Hürthle cell carcinoma"
with Steven L. McKnight, PhD, and Ralph J. DeBerardinis, MD, PhD
Fred Hutchinson Cancer Research Center
Edie I. Crosse, PhD
"Precision therapeutics for hematologic malignancies with splicing factor mutations"
with Robert Bradley, PhD
Tal Einav, PhD
"Quantifying a polyclonal immune repertoire's ability to bind influenza"
with Jesse D. Bloom, PhD, and Jonathan W. Yewdell, MD, PhD
Siqi Li, PhD
"Deciphering clonal competition between oncogenic mutant and normal cells and its effect on cancer initiation"
with Slobodan Beronja, PhD
University of Washington
Junhong Choi, PhD
"Uncovering cellular development in cancer through precise genome editing"
with Jay A. Shendure, MD, PhD
Jean-Benoît Lalanne, PhD
"At-scale dissection of developmental enhancers with single-cell reporters"
with Jay A. Shendure, MD, PhD
