Damon Runyon Researchers

Meet Our Scientists
Jeffrey A. Hussmann, PhD

Dr. Hussmann is studying how translation is regulated in healthy cells and how this regulation goes awry in disease. Cells control protein abundance by modulating how frequently messenger RNAs are translated by ribosomes, but the mechanisms that determine how densely ribosomes are packed onto each individual transcript are poorly understood. He is developing experimental approaches to produce transcriptome‐wide single‐molecule measurements of ribosome density in order to advance this understanding. These approaches will provide insights into the the key role that this process plays in the development and progression of many cancers.

Project title: "Genome-wide measurement of ribosome spacing on individual transcripts"
Institution: University of California, San Francisco
Named Award: Rebecca Ridley Kry Fellow
Award Program: Fellow
Sponsor(s) / Mentor(s): Carol Gross, PhD
Cancer Type: All Cancers
Research Area: Genomics