Damon Runyon Researchers

Meet Our Scientists
Nir Hananya, PhD

Dr. Hananya is investigating a component of the DNA repair machinery termed protein ADP-ribosylation. Our cells are constantly exposed to chemicals and electromagnetic radiation harmful to DNA. Since the integrity of our genetic material is critical, cells have evolved a variety of mechanisms to repair lesions in the DNA. But defects in these DNA repair pathways caused by genetic mutations can lead to genomic instability, which drives cancer development. Dr. Hananya is utilizing chemical biology to study ADP-ribosylation and to delineate its role in DNA repair. The research will provide vital information regarding cancer genesis and progression and will contribute to the development of new therapies.

Project title: "The roles of histone ADP-ribosylation in DNA damage response"
Institution: Princeton University
Named Award: Robert Black Fellow
Award Program: Fellow
Sponsor(s) / Mentor(s): Tom W. Muir, PhD
Cancer Type: Pancreatic, All Cancers
Research Area: Chromatin Biology