Christina A. Stephens, PhD

Solid tumors, like those commonly found in breast and lung cancers, are challenging to treat using state-of-the-art cell engineering techniques due to their heterogeneous surface proteins. There is thus a need to identify unique markers on tumor cells that can be used as molecular targets. Recently, a subclass of surface proteins known as aGPCRs has been recognized as potential markers and propagators of several cancers, but little is known about their molecular mechanism. Dr. Stephen’s research uses single-molecule microscopy coupled with molecular dynamics simulations to provide a detailed picture of the factors that control aGPCR activation. Dr. Stephens will ultimately use these assays to screen and optimize therapeutic targeting of aGPCRs implicated in cancer. Dr. Stephens received her PhD from the University of California, San Francisco, and her BS from the College of William and Mary, Williamsburg.