Juntao Yu, PhD

Asymmetric cell division is a mechanism by which adult stem cells generate one self-renewing stem cell and one differentiating daughter cell in order to maintain tissue homeostasis. A fundamental unsolved question is how two daughter cells adopt distinct cell fates (e.g., how one becomes a blood cell and one becomes a blood vessel cell) to prevent unchecked proliferation and tumorigenesis. Using fruit flies as a model system, Dr. Yu will investigate the selective inheritance of chromosomes for cell fate decision during asymmetric divisions of stem cells. This work will reveal a fundamental principle of how stem cells use chromatin-based mechanisms to determine cell fate and maintain homeostasis. Moreover, it will provide key insights into how cancer cells hijack these pathways to sustain their immortality and uncover novel vulnerabilities in cancer that could be targeted therapeutically. Dr. Yu received his PhD from Harvard University, Cambridge, and his BS from the University of Science and Technology of China, Hefei.