Shihui Chen, PhD

During the first days of embryogenesis, genetically identical cells begin the process of differentiation, switching genes “on” or “off” to establish distinct cell lineages that will ultimately form the embryo and supporting tissues. Aberrant reactivation of these embryonic gene regulatory programs later in life is a hallmark of many cancers. Dr. Chen’s research investigates how genetically identical cells acquire distinct fates during early mammalian development and explores the shared gene regulatory mechanisms that govern both development and cancer. Using mouse embryos as a model system, she will determine how CARM1, a regulator that is frequently overexpressed in human cancers, controls gene expression programs that drive early cell fate decisions. This work will reveal fundamental mechanisms that establish and maintain cellular identity and provide insight into how developmental pathways are hijacked during cancer initiation and progression. Dr. Chen received her PhD from the University of Southern California, Los Angeles, and her BS from Huazhong University of Science and Technology, Wuhan.