Sydney X. Lu, MD, PhD

Dr. Lu studies mutations in a gene called SF3B1 that are commonly found in chronic lymphocytic leukemia (CLL), the most common form of adult leukemia. Patients whose leukemia carries SF3B1 mutations often have worse outcomes, but scientists do not fully understand why. This project aims to determine how mutations in SF3B1 change the behavior of leukemia cells to drive cancer growth and identify treatments that may selectively destroy leukemia cells carrying these mutations while minimizing harm to healthy cells. By improving understanding of how SF3B1 mutations contribute to CLL, this work may help guide the development of more effective and more precise therapies for patients.