Dr. Cambier [HHMI Fellow] studies the role of cells called macrophages in mediating inflammation in immune responses to cancer. He is using the Mycobacterium marinum/zebrafish model of infection to examine misguided immune responses, many of which are shared with cancer. In particular, he proposes to study the distribution of a mycobacterial glycolipid molecule that is associated with driving macrophage activation and death, and will visualize the interactions of these glycolipids with macrophages in a living system. This new imaging approach along with the ability to manipulate host and pathogen genetics in a controlled setting will shed light on the inflammatory mechanisms driving disease. He hopes these findings will lead to new cancer therapies that modulate macrophages.
Damon Runyon Researchers
Meet Our ScientistsChristopher J. Cambier, PhD
Project title: "In vivo characterization of mycobacterial cording"
Institution: Stanford Universities
Named Award: HHMI Fellow
Award Program: Fellow
Sponsor(s) / Mentor(s): Carolyn Bertozzi, PhD
Cancer Type: All Cancers
Research Area: Infectious Disease