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Many cancer immunotherapies, drugs that activate a patient’s immune system, have emerged in recent years, but none are universally effective. To address this shortcoming, Clinical Investigator Anusha Kalbasi, MD, and colleagues at the University of California Los Angeles found a drug that activates the body's natural defenses by behaving like a virus and may uncloak certain stealthy melanoma tumors, so they can be better targeted by immunotherapy.
Former Damon Runyon Innovator Guillem Pratx, PhD, and colleagues at Stanford University have devised a way to use a common imaging technology called positron emission tomography, or PET, to watch the movement of a single cell injected into a laboratory mouse in real time.
In developing a treatment plan for a patient, doctors rely on genetic tests on biopsied tumors in bulk rather than individual cells, which fails to capture the full extent of cellular diversity within tumors. A more complete picture of what is happening in a lung cancer tumor could yield clues for effective therapies that may benefit patients.
Seven Damon Runyon scientists are recipients of the National Institutes of Health's High-Risk, High-Reward Research awards that will fund highly innovative and unusually impactful biomedical research proposed by extraordinarily creative scientists.
Lung cancer is often missed in its earlier stages and, as a result, is the leading cause of cancer deaths in the United States. To tackle this issue, Damon Runyon Fellow Aaron L. Moye, PhD, and colleagues have developed a platform to study early-stage lung cancer and to identify potential new treatments.
Faster, cheaper diagnostic tests for COVID-19 could potentially help control the spread of disease and facilitate safe openings of schools and businesses. Former Damon Runyon Innovator Feng Zhang, PhD, and colleagues have developed a CRISPR-based diagnostic for COVID-19 that gives accurate results in less than an hour and, in principle, could be made inexpensively to allow for regular testing at home.
COVID-19 has mobilized scientists across the globe in an unprecedented effort to understand the SARS-CoV-2 virus and stop this disease. Some Damon Runyon scientists have temporarily pivoted their research to contribute to this critical goal by investigating how the virus enters human cells, developing more efficient testing, and searching for treatments.
Former Damon Runyon Fellow John Blenis, PhD, and colleagues at Weill Cornell Medicine have discovered a molecule produced by our own cells that can accumulate in the blood as we age and help cancer cells spread from one site in the body to others. The researchers found that the level of methylmalonic acid (MMA)—a by-product of protein and fat digestion—is significantly higher in the blood of otherwise healthy people over the age of 60.
Former Damon Runyon Clinical Investigator Andrew T. Chan, MD, MPH, and his colleagues at Massachusetts General Hospital in Boston and Monash University in Melbourne, Australia, have published surprising new results that for older individuals with advanced cancer, taking aspirin may increase their risk of cancer growth and early death.
Damon Runyon Fellow Lindsay M. LaFave, PhD, and colleagues at Massachusetts Institute of Technology and Harvard University, discovered that elevated levels of a protein called RUNX2 in human lung tumors predict a worse prognosis—a finding which could lead to new diagnostics and drug targets.
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